SUPT16H report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0006368Biological processtranscription elongation by RNA polymerase II
GO_0006281Biological processDNA repair
GO_0006337Biological processnucleosome disassembly
GO_0032786Biological processpositive regulation of DNA-templated transcription, elongation
GO_0006260Biological processDNA replication
GO_0006334Biological processnucleosome assembly
GO_0035101Cellular componentFACT complex
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0031491Molecular functionnucleosome binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameSUPT16H
Protein nameFACT complex subunit
SPT16 homolog, facilitates chromatin remodeling subunit
FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16)
SynonymsFACT140
FACTP140
DescriptionFUNCTION: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). .

FUNCTION: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. .

AccessionsENST00000216297.7
G3V401
Q9Y5B9
G3V5A4
ENST00000557652.1
ENST00000555943.1
Q0VGA3
ENST00000556309.5
G3V2X0