SKAP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	38 studies	40% ± 16%	Explore
CD8-positive, alpha-beta T cell	33 studies	37% ± 15%	Explore
CD4-positive, alpha-beta T cell	31 studies	37% ± 15%	Explore
regulatory T cell	29 studies	48% ± 17%	Explore
T cell	26 studies	39% ± 18%	Explore
mast cell	21 studies	33% ± 17%	Explore
mature NK T cell	21 studies	38% ± 13%	Explore
gamma-delta T cell	17 studies	38% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	42% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	33% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	47% ± 13%	Explore
mucosal invariant T cell	14 studies	39% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	33% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	36% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	40% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	46% ± 17%	Explore
naive B cell	9 studies	19% ± 3%	Explore
T follicular helper cell	7 studies	32% ± 8%	Explore
innate lymphoid cell	7 studies	32% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	42% ± 20%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	38% ± 13%	Explore
B cell	6 studies	25% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	40% ± 14%	Explore
exhausted T cell	5 studies	45% ± 9%	Explore
leukocyte	5 studies	42% ± 28%	Explore
lymphocyte	5 studies	60% ± 27%	Explore
CD4-positive helper T cell	4 studies	26% ± 11%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	34% ± 11%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	27% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	53% ± 6%	Explore
T-helper 17 cell	4 studies	27% ± 3%	Explore
intraepithelial lymphocyte	3 studies	39% ± 15%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 10%	Explore
T-helper 1 cell	3 studies	37% ± 9%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	38% ± 9%	Explore
double negative thymocyte	3 studies	43% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	25% ± 4%	Explore
kidney	5 studies	28% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	894.39	89 / 89	91%	22.97	824 / 901
lung	99%	281.06	573 / 578	77%	11.59	884 / 1155
pancreas	83%	125.29	272 / 328	89%	20.11	159 / 178
breast	75%	183.09	343 / 459	84%	23.12	944 / 1118
liver	99%	523.74	223 / 226	58%	7.97	234 / 406
stomach	66%	81.64	238 / 359	80%	11.62	229 / 286
intestine	59%	174.49	574 / 966	83%	14.19	440 / 527
bladder	67%	234.48	14 / 21	68%	11.11	345 / 504
adrenal gland	100%	644.07	257 / 258	29%	6.77	66 / 230
uterus	58%	84.29	99 / 170	67%	10.88	306 / 459
thymus	65%	108.91	424 / 653	41%	9.57	249 / 605
ovary	11%	11.65	20 / 180	92%	18.46	396 / 430
spleen	100%	846.88	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	12.58	1 / 1
peripheral blood	99%	1806.73	924 / 929	0%	0	0 / 0
prostate	74%	111.55	182 / 245	23%	1.64	115 / 502
lymph node	0%	0	0 / 0	97%	54.74	28 / 29
esophagus	41%	47.63	590 / 1445	50%	6.22	92 / 183
tonsil	0%	0	0 / 0	89%	15.17	40 / 45
skin	31%	31.74	553 / 1809	50%	10.01	237 / 472
adipose	69%	94.88	827 / 1204	0%	0	0 / 0
blood vessel	18%	23.92	242 / 1335	0%	0	0 / 0
brain	8%	14.00	213 / 2642	1%	0.19	10 / 705
eye	0%	0	0 / 0	6%	0.41	5 / 80
heart	4%	4.18	36 / 861	0%	0	0 / 0
muscle	0%	0.32	3 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0072659	Biological process	protein localization to plasma membrane
GO_0001954	Biological process	positive regulation of cell-matrix adhesion
GO_0033634	Biological process	positive regulation of cell-cell adhesion mediated by integrin
GO_1903039	Biological process	positive regulation of leukocyte cell-cell adhesion
GO_0050852	Biological process	T cell receptor signaling pathway
GO_0002250	Biological process	adaptive immune response
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0002821	Biological process	positive regulation of adaptive immune response
GO_0034116	Biological process	positive regulation of heterotypic cell-cell adhesion
GO_0033625	Biological process	positive regulation of integrin activation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0001772	Cellular component	immunological synapse
GO_0005886	Cellular component	plasma membrane
GO_0005654	Cellular component	nucleoplasm
GO_0005911	Cellular component	cell-cell junction
GO_0044853	Cellular component	plasma membrane raft
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0042101	Cellular component	T cell receptor complex
GO_0019903	Molecular function	protein phosphatase binding
GO_0019901	Molecular function	protein kinase binding
GO_0042169	Molecular function	SH2 domain binding
GO_0005515	Molecular function	protein binding
GO_0017124	Molecular function	SH3 domain binding

IV. Literature review

[source]

Gene name	SKAP1
Protein name	Src kinase associated phosphoprotein 1 Src kinase-associated phosphoprotein 1 (Src family-associated phosphoprotein 1) (Src kinase-associated phosphoprotein of 55 kDa) (SKAP-55) (pp55)
Synonyms	SCAP1 SKAP55
Description	FUNCTION: Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. .
Accessions	J3KS83 J3QKX8 J3QS38 ENST00000581400.2 J3KSD4 ENST00000583844.5 ENST00000584924.5 [Q86WV1-1] ENST00000336915.11 [Q86WV1-1] ENST00000579336.1 Q86WV1 ENST00000581419.1 ENST00000584709.5 J3QRG3

SKAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review