Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 7382.02 | 226 / 226 | 100% | 27.15 | 406 / 406 |
| intestine | 100% | 1983.93 | 966 / 966 | 100% | 11.31 | 525 / 527 |
| adrenal gland | 100% | 1852.30 | 258 / 258 | 100% | 15.44 | 229 / 230 |
| thymus | 100% | 2275.28 | 653 / 653 | 100% | 16.82 | 602 / 605 |
| skin | 100% | 1138.24 | 1807 / 1809 | 100% | 17.61 | 470 / 472 |
| esophagus | 100% | 1524.55 | 1445 / 1445 | 99% | 12.13 | 182 / 183 |
| stomach | 100% | 1301.25 | 359 / 359 | 99% | 11.96 | 284 / 286 |
| prostate | 100% | 2503.49 | 245 / 245 | 99% | 9.65 | 498 / 502 |
| uterus | 100% | 2376.56 | 170 / 170 | 99% | 15.74 | 455 / 459 |
| bladder | 100% | 1920.48 | 21 / 21 | 99% | 13.89 | 499 / 504 |
| lung | 100% | 2392.64 | 578 / 578 | 99% | 11.21 | 1140 / 1155 |
| pancreas | 99% | 851.62 | 324 / 328 | 99% | 16.52 | 177 / 178 |
| ovary | 100% | 2214.32 | 180 / 180 | 98% | 19.41 | 422 / 430 |
| breast | 100% | 1731.52 | 459 / 459 | 98% | 12.35 | 1094 / 1118 |
| kidney | 100% | 2342.35 | 89 / 89 | 98% | 12.69 | 881 / 901 |
| brain | 100% | 1800.05 | 2639 / 2642 | 97% | 13.21 | 687 / 705 |
| eye | 0% | 0 | 0 / 0 | 100% | 16.04 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 17.34 | 29 / 29 |
| spleen | 100% | 3499.40 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 13.21 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 10.94 | 1 / 1 |
| adipose | 100% | 1650.75 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1668.44 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 1806.82 | 911 / 929 | 0% | 0 | 0 / 0 |
| heart | 96% | 808.62 | 830 / 861 | 0% | 0 | 0 / 0 |
| muscle | 21% | 86.90 | 165 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0045071 | Biological process | negative regulation of viral genome replication |
| GO_0006449 | Biological process | regulation of translational termination |
| GO_2001125 | Biological process | negative regulation of translational frameshifting |
| GO_0045087 | Biological process | innate immune response |
| GO_0051607 | Biological process | defense response to virus |
| GO_0034341 | Biological process | response to type II interferon |
| GO_0034340 | Biological process | response to type I interferon |
| GO_0035456 | Biological process | response to interferon-beta |
| GO_0075523 | Biological process | viral translational frameshifting |
| GO_0034342 | Biological process | response to type III interferon |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0000932 | Cellular component | P-body |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_1990825 | Molecular function | sequence-specific mRNA binding |
| GO_0043022 | Molecular function | ribosome binding |
| GO_0003723 | Molecular function | RNA binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SHFL |
| Protein name | Shiftless antiviral inhibitor of ribosomal frameshifting protein (SFL) (SHFL) (Interferon-regulated antiviral protein) (IRAV) (Repressor of yield of DENV protein) (RyDEN) Shiftless antiviral inhibitor of ribosomal frameshifting |
| Synonyms | FLJ11286 IRAV SFL C19orf66 RYDEN |
| Description | FUNCTION: Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses, such as HIV1, and cellular genes, such as PEG10. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site . Regulates HIV1 GAG-POL expression by inhibiting -1PRF . Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Interrupts also Zika virus replication by promoting viral NS3 degradation via a lysosome-dependent pathway . Can also limit the replication of hepatitis C virus (HCV) by restricting formation of viral replication organelle, West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1), herpes virus type 8 (HHV-8) and human adenovirus . Binds nucleic acids with a higher affinity for ssRNA and ssDNA than for dsDNA . .; FUNCTION: Isoform 4 does not inhibit programmed ribosomal frameshifting (-1PRF). Does not bind to ribosomes. . |
| Accessions | ENST00000253110.16 [Q9NUL5-1] K7ELT7 K7EML3 ENST00000586889.1 K7EMS9 ENST00000587710.5 ENST00000397881.7 [Q9NUL5-2] ENST00000591813.5 [Q9NUL5-4] ENST00000593131.1 K7EP02 ENST00000590378.5 Q9NUL5 |
