SF3A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0006397Biological processmRNA processing
GO_0000389Biological processmRNA 3'-splice site recognition
GO_1903241Biological processU2-type prespliceosome assembly
GO_0045292Biological processmRNA cis splicing, via spliceosome
GO_0005686Cellular componentU2 snRNP
GO_0016607Cellular componentnuclear speck
GO_0071004Cellular componentU2-type prespliceosome
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0005654Cellular componentnucleoplasm
GO_0005681Cellular componentspliceosomal complex
GO_0071005Cellular componentU2-type precatalytic spliceosome
GO_0005684Cellular componentU2-type spliceosomal complex
GO_0005634Cellular componentnucleus
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSF3A1
Protein nameSplicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114)
Splicing factor 3a subunit 1
SynonymsSAP114
DescriptionFUNCTION: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs . The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing . Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex . Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes . .

AccessionsENST00000444440.1
ENST00000411423.1
ENST00000215793.13 [Q15459-1]
ENST00000447376.1
F8WB66
F8WC79
Q15459
H7C1L2