SEC13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051028Biological processmRNA transport
GO_0032527Biological processprotein exit from endoplasmic reticulum
GO_0090114Biological processCOPII-coated vesicle budding
GO_0006886Biological processintracellular protein transport
GO_0031669Biological processcellular response to nutrient levels
GO_0006606Biological processprotein import into nucleus
GO_0006913Biological processnucleocytoplasmic transport
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0032008Biological processpositive regulation of TOR signaling
GO_0090110Biological processCOPII-coated vesicle cargo loading
GO_0005643Cellular componentnuclear pore
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0000776Cellular componentkinetochore
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0030127Cellular componentCOPII vesicle coat
GO_0061700Cellular componentGATOR2 complex
GO_0005635Cellular componentnuclear envelope
GO_0005829Cellular componentcytosol
GO_0031080Cellular componentnuclear pore outer ring
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0012507Cellular componentER to Golgi transport vesicle membrane
GO_0005765Cellular componentlysosomal membrane
GO_0042802Molecular functionidentical protein binding
GO_0005198Molecular functionstructural molecule activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSEC13
Protein nameSEC13 homolog, nuclear pore and COPII coat complex component
Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein)
Protein SEC13 homolog
SynonymsSEC13L1
SEC13A
SEC13R
D3S1231E
DescriptionFUNCTION: Functions as a component of the nuclear pore complex (NPC) and the COPII coat . At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles . Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity). .; FUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway . The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex . GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 . In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation . In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex . Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex . .

AccessionsENST00000397109.7 [P55735-2]
E7ERC8
A8MXL6
ENST00000432213.1
ENST00000383801.6 [P55735-3]
ENST00000397117.5
P55735
C9JBJ5
ENST00000337354.8 [P55735-4]
C9J0S2
ENST00000445064.1
ENST00000350697.8 [P55735-1]
C9JIB6
ENST00000431352.1
ENST00000428626.5