RNF114 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0007283Biological processspermatogenesis
GO_0000209Biological processprotein polyubiquitination
GO_0030154Biological processcell differentiation
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRNF114
Protein nameE3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313)
E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)
Ring finger protein 114
SynonymsZNF228
ZNF313
DescriptionFUNCTION: E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates . In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity . Acts as a negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 . May promote the ubiquitination of TRAF6 as well . Acts also as a negative regulator of T-cell activation . Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation . Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C . This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis. .

AccessionsA0A096LNN8
ENST00000622920.1
ENST00000625177.3
A0A096LPF9
ENST00000622999.3
A0A096LP02
ENST00000623528.3
ENST00000244061.6 [Q9Y508-1]
A0A096LNT1
Q9Y508
ENST00000623732.3
A0A096LNV3