RAB1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000045Biological processautophagosome assembly
GO_0006886Biological processintracellular protein transport
GO_0007030Biological processGolgi organization
GO_2000785Biological processregulation of autophagosome assembly
GO_0019068Biological processvirion assembly
GO_0090557Biological processestablishment of endothelial intestinal barrier
GO_1903020Biological processpositive regulation of glycoprotein metabolic process
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0012505Cellular componentendomembrane system
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0034045Cellular componentphagophore assembly site membrane
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0030133Cellular componenttransport vesicle
GO_0003925Molecular functionG protein activity
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRAB1B
Protein namesmall monomeric GTPase (EC 3.6.5.2)
Ras-related protein Rab-1B (EC 3.6.5.2)
Ras-related protein Rab-1A
Synonyms
DescriptionFUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes . Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion . Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum . Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Required to modulate the compacted morphology of the Golgi . Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity). .

AccessionsE9PLD0
Q9H0U4
ENST00000311481.11
Q6FIG4
ENST00000527397.1