PSMC1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	28 studies	25% ± 12%	Explore
fibroblast	22 studies	25% ± 12%	Explore
natural killer cell	21 studies	21% ± 6%	Explore
smooth muscle cell	20 studies	23% ± 6%	Explore
pericyte	17 studies	23% ± 5%	Explore
regulatory T cell	15 studies	19% ± 3%	Explore
macrophage	14 studies	25% ± 9%	Explore
CD8-positive, alpha-beta T cell	12 studies	23% ± 6%	Explore
conventional dendritic cell	12 studies	25% ± 14%	Explore
classical monocyte	11 studies	25% ± 12%	Explore
mast cell	10 studies	20% ± 3%	Explore
non-classical monocyte	10 studies	27% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	21% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	21% ± 4%	Explore
epithelial cell	10 studies	32% ± 19%	Explore
basal cell	10 studies	29% ± 16%	Explore
ciliated cell	10 studies	30% ± 13%	Explore
CD4-positive, alpha-beta T cell	9 studies	23% ± 5%	Explore
myofibroblast cell	9 studies	25% ± 6%	Explore
connective tissue cell	9 studies	25% ± 8%	Explore
capillary endothelial cell	9 studies	21% ± 4%	Explore
T cell	9 studies	21% ± 5%	Explore
vein endothelial cell	8 studies	21% ± 5%	Explore
gamma-delta T cell	8 studies	24% ± 13%	Explore
endothelial cell of lymphatic vessel	7 studies	24% ± 10%	Explore
B cell	7 studies	22% ± 8%	Explore
endothelial cell of artery	7 studies	22% ± 5%	Explore
endothelial cell of vascular tree	7 studies	23% ± 5%	Explore
plasmacytoid dendritic cell	7 studies	21% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	19% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	21% ± 4%	Explore
mature NK T cell	6 studies	18% ± 3%	Explore
neuron	6 studies	34% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	23% ± 6%	Explore
hematopoietic precursor cell	5 studies	30% ± 17%	Explore
innate lymphoid cell	5 studies	19% ± 4%	Explore
myeloid cell	5 studies	21% ± 8%	Explore
monocyte	5 studies	24% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	22% ± 8%	Explore
glutamatergic neuron	5 studies	34% ± 15%	Explore
oligodendrocyte precursor cell	5 studies	23% ± 6%	Explore
pancreatic A cell	4 studies	44% ± 1%	Explore
type B pancreatic cell	4 studies	44% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	26% ± 7%	Explore
exhausted T cell	4 studies	26% ± 10%	Explore
epithelial cell of proximal tubule	4 studies	20% ± 3%	Explore
retinal ganglion cell	4 studies	58% ± 27%	Explore
plasma cell	4 studies	29% ± 10%	Explore
precursor B cell	4 studies	22% ± 8%	Explore
type I pneumocyte	4 studies	27% ± 8%	Explore
dendritic cell	4 studies	41% ± 23%	Explore
goblet cell	4 studies	26% ± 7%	Explore
oligodendrocyte	4 studies	19% ± 1%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	19% ± 3%	Explore
deuterosomal cell	3 studies	19% ± 1%	Explore
leukocyte	3 studies	24% ± 9%	Explore
naive B cell	3 studies	20% ± 3%	Explore
kidney loop of Henle epithelial cell	3 studies	20% ± 1%	Explore
mesothelial cell	3 studies	32% ± 19%	Explore
neural crest cell	3 studies	26% ± 5%	Explore
placental villous trophoblast	3 studies	49% ± 16%	Explore
lymphocyte	3 studies	24% ± 5%	Explore
mucosal invariant T cell	3 studies	18% ± 2%	Explore
club cell	3 studies	23% ± 2%	Explore
astrocyte	3 studies	25% ± 12%	Explore
retina horizontal cell	3 studies	30% ± 15%	Explore
Mueller cell	3 studies	17% ± 1%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
GABAergic neuron	3 studies	33% ± 6%	Explore
pancreatic ductal cell	3 studies	58% ± 9%	Explore
abnormal cell	3 studies	29% ± 7%	Explore
granulocyte monocyte progenitor cell	3 studies	25% ± 13%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	35% ± 21%	Explore
enteroendocrine cell	3 studies	30% ± 12%	Explore
secretory cell	3 studies	33% ± 17%	Explore
mononuclear phagocyte	3 studies	26% ± 11%	Explore
erythroblast	3 studies	37% ± 22%	Explore
double negative thymocyte	3 studies	31% ± 13%	Explore
memory B cell	3 studies	20% ± 2%	Explore
interneuron	3 studies	28% ± 13%	Explore
hepatocyte	3 studies	30% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	11 studies	22% ± 9%	Explore
lung	10 studies	27% ± 12%	Explore
brain	7 studies	25% ± 9%	Explore
kidney	6 studies	19% ± 4%	Explore
intestine	6 studies	22% ± 10%	Explore
eye	5 studies	23% ± 12%	Explore
liver	5 studies	27% ± 19%	Explore
pancreas	4 studies	43% ± 10%	Explore
placenta	4 studies	26% ± 14%	Explore
uterus	4 studies	22% ± 9%	Explore
bone marrow	3 studies	16% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1185.97	1441 / 1445	100%	16.40	183 / 183
stomach	100%	863.11	358 / 359	100%	10.87	286 / 286
ovary	99%	829.54	179 / 180	100%	13.11	430 / 430
intestine	100%	1100.59	966 / 966	99%	9.17	522 / 527
lung	99%	1004.63	575 / 578	100%	10.58	1150 / 1155
breast	100%	1147.29	459 / 459	98%	10.16	1101 / 1118
skin	100%	1431.16	1808 / 1809	97%	8.24	456 / 472
prostate	100%	736.35	244 / 245	97%	7.45	486 / 502
bladder	100%	1120.33	21 / 21	96%	8.19	483 / 504
uterus	100%	1081.58	170 / 170	96%	9.45	439 / 459
thymus	100%	889.60	652 / 653	96%	7.16	578 / 605
brain	96%	697.26	2542 / 2642	99%	8.54	699 / 705
pancreas	95%	497.57	311 / 328	98%	7.59	175 / 178
kidney	100%	734.74	89 / 89	92%	6.51	830 / 901
adrenal gland	98%	1086.87	254 / 258	85%	5.44	196 / 230
liver	79%	484.42	179 / 226	89%	4.60	360 / 406
adipose	100%	1261.14	1204 / 1204	0%	0	0 / 0
blood vessel	100%	1388.27	1335 / 1335	0%	0	0 / 0
muscle	100%	3593.07	803 / 803	0%	0	0 / 0
spleen	100%	840.97	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	9.98	45 / 45
eye	0%	0	0 / 0	96%	6.24	77 / 80
lymph node	0%	0	0 / 0	93%	8.43	27 / 29
heart	93%	1187.06	800 / 861	0%	0	0 / 0
peripheral blood	89%	1036.29	823 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1901800	Biological process	positive regulation of proteasomal protein catabolic process
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502	Cellular component	proteasome complex
GO_0022624	Cellular component	proteasome accessory complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0008540	Cellular component	proteasome regulatory particle, base subcomplex
GO_0016020	Cellular component	membrane
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0036402	Molecular function	proteasome-activating activity
GO_0016887	Molecular function	ATP hydrolysis activity
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	PSMC1
Protein name	26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1) Proteasome (Prosome, macropain) 26S subunit, ATPase, 1 (Proteasome 26S ATPase subunit 1) (cDNA, FLJ93843, Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 1(PSMC1), mRNA) Proteasome 26S subunit, ATPase 1
Synonyms	hCG_2029049
Description	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. .
Accessions	ENST00000261303.13 [P62191-1] G3V4X1 ENST00000553835.5 Q53XL8 P62191 ENST00000543772.2 [P62191-2]

PSMC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review