PPP4R2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	26 studies	26% ± 10%	Explore
fibroblast	20 studies	25% ± 7%	Explore
regulatory T cell	17 studies	21% ± 5%	Explore
natural killer cell	16 studies	20% ± 4%	Explore
oligodendrocyte	13 studies	35% ± 13%	Explore
ciliated cell	11 studies	28% ± 12%	Explore
T cell	10 studies	19% ± 5%	Explore
classical monocyte	10 studies	23% ± 8%	Explore
CD8-positive, alpha-beta T cell	10 studies	21% ± 5%	Explore
pericyte	10 studies	20% ± 3%	Explore
epithelial cell	10 studies	36% ± 22%	Explore
endothelial cell of lymphatic vessel	9 studies	19% ± 4%	Explore
basal cell	9 studies	27% ± 9%	Explore
CD4-positive, alpha-beta T cell	9 studies	22% ± 7%	Explore
microglial cell	9 studies	24% ± 7%	Explore
smooth muscle cell	9 studies	20% ± 2%	Explore
macrophage	9 studies	24% ± 7%	Explore
B cell	8 studies	19% ± 3%	Explore
secretory cell	8 studies	25% ± 9%	Explore
myofibroblast cell	8 studies	24% ± 7%	Explore
gamma-delta T cell	8 studies	25% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	20% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	21% ± 4%	Explore
naive B cell	7 studies	19% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	21% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	21% ± 4%	Explore
mature NK T cell	7 studies	19% ± 3%	Explore
connective tissue cell	7 studies	20% ± 3%	Explore
astrocyte	7 studies	29% ± 10%	Explore
glutamatergic neuron	7 studies	39% ± 22%	Explore
oligodendrocyte precursor cell	7 studies	26% ± 10%	Explore
monocyte	6 studies	19% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	19% ± 3%	Explore
lymphocyte	6 studies	22% ± 8%	Explore
mucosal invariant T cell	6 studies	19% ± 2%	Explore
adipocyte	6 studies	27% ± 6%	Explore
GABAergic neuron	6 studies	34% ± 16%	Explore
club cell	5 studies	21% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	19% ± 4%	Explore
non-classical monocyte	5 studies	24% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 4%	Explore
neuron	5 studies	40% ± 16%	Explore
myeloid cell	5 studies	26% ± 10%	Explore
T follicular helper cell	5 studies	19% ± 2%	Explore
endothelial cell of vascular tree	5 studies	21% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	20% ± 5%	Explore
goblet cell	5 studies	28% ± 15%	Explore
interneuron	5 studies	33% ± 20%	Explore
plasmacytoid dendritic cell	5 studies	21% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	19% ± 4%	Explore
leukocyte	4 studies	20% ± 1%	Explore
conventional dendritic cell	4 studies	28% ± 13%	Explore
exhausted T cell	4 studies	21% ± 6%	Explore
abnormal cell	4 studies	29% ± 15%	Explore
progenitor cell	4 studies	18% ± 3%	Explore
capillary endothelial cell	4 studies	20% ± 4%	Explore
retinal pigment epithelial cell	4 studies	27% ± 10%	Explore
cardiac muscle cell	4 studies	25% ± 2%	Explore
innate lymphoid cell	4 studies	18% ± 2%	Explore
memory B cell	4 studies	17% ± 2%	Explore
hepatocyte	4 studies	43% ± 19%	Explore
type I pneumocyte	4 studies	21% ± 5%	Explore
mast cell	4 studies	19% ± 5%	Explore
hematopoietic precursor cell	3 studies	32% ± 11%	Explore
neutrophil	3 studies	20% ± 2%	Explore
respiratory goblet cell	3 studies	18% ± 2%	Explore
glial cell	3 studies	24% ± 8%	Explore
precursor B cell	3 studies	23% ± 3%	Explore
immature B cell	3 studies	21% ± 5%	Explore
pro-B cell	3 studies	26% ± 4%	Explore
type II pneumocyte	3 studies	22% ± 4%	Explore
retina horizontal cell	3 studies	23% ± 6%	Explore
retinal cone cell	3 studies	23% ± 5%	Explore
mesothelial cell	3 studies	24% ± 6%	Explore
rod bipolar cell	3 studies	18% ± 3%	Explore
enteroendocrine cell	3 studies	26% ± 9%	Explore
intestinal crypt stem cell	3 studies	17% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	30% ± 11%	Explore
transit amplifying cell	3 studies	26% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	31% ± 17%	Explore
lung	10 studies	24% ± 9%	Explore
peripheral blood	9 studies	22% ± 6%	Explore
adipose	4 studies	18% ± 2%	Explore
eye	3 studies	25% ± 7%	Explore
heart	3 studies	20% ± 2%	Explore
uterus	3 studies	28% ± 12%	Explore
liver	3 studies	38% ± 16%	Explore
intestine	3 studies	25% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	2875.07	459 / 459	100%	45.08	1118 / 1118
esophagus	100%	2540.67	1445 / 1445	100%	31.45	183 / 183
lung	100%	3278.13	578 / 578	100%	30.60	1155 / 1155
ovary	100%	3522.55	180 / 180	100%	33.90	430 / 430
prostate	100%	2555.68	245 / 245	100%	33.92	502 / 502
brain	100%	2184.40	2639 / 2642	100%	31.76	705 / 705
uterus	100%	3021.44	170 / 170	100%	34.72	457 / 459
thymus	100%	2936.26	653 / 653	100%	37.54	602 / 605
liver	100%	3033.26	226 / 226	99%	28.69	403 / 406
kidney	100%	1854.03	89 / 89	99%	24.26	892 / 901
bladder	100%	2688.57	21 / 21	99%	33.05	498 / 504
adrenal gland	100%	3259.48	258 / 258	99%	22.20	227 / 230
pancreas	100%	1352.85	327 / 328	99%	27.46	176 / 178
stomach	100%	1973.66	359 / 359	98%	30.57	279 / 286
intestine	100%	2712.02	966 / 966	97%	31.31	512 / 527
skin	100%	2646.59	1806 / 1809	96%	40.25	454 / 472
adipose	100%	3139.76	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2724.30	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	36.03	29 / 29
muscle	100%	3009.02	803 / 803	0%	0	0 / 0
spleen	100%	2660.35	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	29.82	45 / 45
ureter	0%	0	0 / 0	100%	17.04	1 / 1
heart	99%	2232.95	852 / 861	0%	0	0 / 0
peripheral blood	93%	2974.43	864 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	86%	16.30	69 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010569	Biological process	regulation of double-strand break repair via homologous recombination
GO_0008380	Biological process	RNA splicing
GO_0006397	Biological process	mRNA processing
GO_0036211	Biological process	protein modification process
GO_2000779	Biological process	regulation of double-strand break repair
GO_0030289	Cellular component	protein phosphatase 4 complex
GO_0005813	Cellular component	centrosome
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0019888	Molecular function	protein phosphatase regulator activity
GO_0030674	Molecular function	protein-macromolecule adaptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PPP4R2
Protein name	Serine/threonine-protein phosphatase 4 regulatory subunit 2 Protein phosphatase 4 regulatory subunit 2 HCG14948, isoform CRA_a (Protein phosphatase 4 regulatory subunit 2)
Synonyms	SBBI57 hCG_14948
Description	FUNCTION: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. .
Accessions	Q9NY27 ENST00000482242.5 A0AA34QVI2 H7C559 C9IZF4 ENST00000495566.1 F8WDK3 ENST00000476505.2 ENST00000710398.1 C9IZ04 F8WCA1 ENST00000356692.10 [Q9NY27-1] ENST00000460360.1 ENST00000488810.5

PPP4R2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review