PPP2R2A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	37 studies	33% ± 14%	Explore
fibroblast	16 studies	27% ± 8%	Explore
oligodendrocyte	15 studies	48% ± 19%	Explore
pericyte	14 studies	24% ± 10%	Explore
oligodendrocyte precursor cell	13 studies	37% ± 19%	Explore
endothelial cell of artery	13 studies	28% ± 11%	Explore
basal cell	13 studies	36% ± 17%	Explore
macrophage	12 studies	28% ± 13%	Explore
microglial cell	12 studies	33% ± 11%	Explore
smooth muscle cell	12 studies	23% ± 4%	Explore
epithelial cell	12 studies	37% ± 22%	Explore
endothelial cell of vascular tree	12 studies	25% ± 16%	Explore
natural killer cell	11 studies	20% ± 4%	Explore
ciliated cell	11 studies	32% ± 14%	Explore
capillary endothelial cell	11 studies	23% ± 6%	Explore
astrocyte	11 studies	29% ± 11%	Explore
type I pneumocyte	9 studies	29% ± 11%	Explore
B cell	9 studies	22% ± 4%	Explore
vein endothelial cell	9 studies	30% ± 20%	Explore
GABAergic neuron	8 studies	33% ± 17%	Explore
CD4-positive, alpha-beta T cell	8 studies	19% ± 3%	Explore
adipocyte	8 studies	36% ± 10%	Explore
regulatory T cell	8 studies	18% ± 4%	Explore
glutamatergic neuron	8 studies	44% ± 25%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	18% ± 1%	Explore
neuron	7 studies	39% ± 24%	Explore
myeloid cell	7 studies	23% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	19% ± 3%	Explore
interneuron	6 studies	33% ± 19%	Explore
club cell	6 studies	31% ± 8%	Explore
type II pneumocyte	6 studies	28% ± 8%	Explore
monocyte	6 studies	24% ± 6%	Explore
goblet cell	6 studies	31% ± 27%	Explore
classical monocyte	5 studies	20% ± 5%	Explore
leukocyte	5 studies	24% ± 8%	Explore
naive B cell	5 studies	20% ± 4%	Explore
non-classical monocyte	5 studies	22% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	18% ± 1%	Explore
mature NK T cell	5 studies	21% ± 9%	Explore
connective tissue cell	5 studies	20% ± 3%	Explore
CD8-positive, alpha-beta T cell	5 studies	20% ± 3%	Explore
dendritic cell	5 studies	29% ± 8%	Explore
secretory cell	5 studies	29% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	19% ± 1%	Explore
endothelial cell of lymphatic vessel	5 studies	30% ± 13%	Explore
T cell	5 studies	21% ± 4%	Explore
squamous epithelial cell	4 studies	44% ± 20%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	17% ± 1%	Explore
abnormal cell	4 studies	27% ± 15%	Explore
myofibroblast cell	4 studies	25% ± 8%	Explore
retinal bipolar neuron	4 studies	34% ± 19%	Explore
cardiac muscle cell	4 studies	18% ± 1%	Explore
lymphocyte	4 studies	32% ± 13%	Explore
Mueller cell	4 studies	23% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	27% ± 9%	Explore
mast cell	4 studies	20% ± 4%	Explore
luminal cell of prostate epithelium	4 studies	21% ± 7%	Explore
enteroendocrine cell	4 studies	24% ± 6%	Explore
respiratory goblet cell	4 studies	37% ± 8%	Explore
conventional dendritic cell	3 studies	26% ± 11%	Explore
glial cell	3 studies	27% ± 9%	Explore
granule cell	3 studies	22% ± 3%	Explore
progenitor cell	3 studies	21% ± 4%	Explore
plasma cell	3 studies	31% ± 5%	Explore
precursor B cell	3 studies	20% ± 3%	Explore
amacrine cell	3 studies	22% ± 2%	Explore
retina horizontal cell	3 studies	20% ± 4%	Explore
retinal cone cell	3 studies	27% ± 7%	Explore
retinal rod cell	3 studies	18% ± 3%	Explore
mesothelial cell	3 studies	25% ± 7%	Explore
OFF-bipolar cell	3 studies	26% ± 7%	Explore
ON-bipolar cell	3 studies	31% ± 9%	Explore
rod bipolar cell	3 studies	37% ± 9%	Explore
gamma-delta T cell	3 studies	29% ± 12%	Explore
memory B cell	3 studies	17% ± 1%	Explore
hepatocyte	3 studies	54% ± 29%	Explore
muscle cell	3 studies	36% ± 23%	Explore
neural progenitor cell	3 studies	21% ± 5%	Explore
ependymal cell	3 studies	32% ± 14%	Explore
adventitial cell	3 studies	22% ± 4%	Explore
alveolar macrophage	3 studies	28% ± 10%	Explore
transit amplifying cell	3 studies	38% ± 30%	Explore
keratinocyte	3 studies	25% ± 6%	Explore
mural cell	3 studies	34% ± 15%	Explore
mucus secreting cell	3 studies	30% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	37% ± 22%	Explore
lung	11 studies	26% ± 9%	Explore
eye	6 studies	26% ± 15%	Explore
liver	4 studies	31% ± 16%	Explore
intestine	4 studies	21% ± 6%	Explore
adipose	4 studies	22% ± 5%	Explore
peripheral blood	3 studies	23% ± 2%	Explore
heart	3 studies	20% ± 3%	Explore
breast	3 studies	19% ± 4%	Explore
esophagus	3 studies	29% ± 18%	Explore
prostate	3 studies	25% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4364.53	1445 / 1445	100%	28.69	183 / 183
lung	100%	3648.28	578 / 578	100%	24.02	1154 / 1155
brain	100%	2610.10	2639 / 2642	100%	23.21	705 / 705
breast	100%	4143.30	459 / 459	100%	26.62	1116 / 1118
ovary	100%	3365.79	180 / 180	100%	18.63	429 / 430
prostate	100%	3224.20	245 / 245	100%	24.69	500 / 502
uterus	100%	3468.19	170 / 170	100%	24.04	457 / 459
thymus	100%	2983.78	653 / 653	100%	22.61	602 / 605
intestine	100%	2687.85	966 / 966	99%	23.54	524 / 527
bladder	100%	3394.57	21 / 21	99%	22.06	500 / 504
stomach	100%	1997.62	359 / 359	99%	22.71	283 / 286
kidney	100%	2177.20	89 / 89	97%	15.96	878 / 901
skin	100%	4536.10	1809 / 1809	97%	21.60	458 / 472
pancreas	98%	1249.86	320 / 328	99%	18.94	176 / 178
adrenal gland	100%	2208.83	258 / 258	94%	11.14	216 / 230
liver	100%	1458.95	225 / 226	74%	6.65	302 / 406
adipose	100%	4061.43	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3062.65	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	16.22	29 / 29
muscle	100%	3656.71	803 / 803	0%	0	0 / 0
spleen	100%	2747.67	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	30.26	45 / 45
heart	99%	2326.88	850 / 861	0%	0	0 / 0
peripheral blood	98%	3145.58	914 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	90%	10.85	72 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006470	Biological process	protein dephosphorylation
GO_0043278	Biological process	response to morphine
GO_0098978	Cellular component	glutamatergic synapse
GO_0000159	Cellular component	protein phosphatase type 2A complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0019888	Molecular function	protein phosphatase regulator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PPP2R2A
Protein name	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B Protein phosphatase 2 regulatory subunit Balpha Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha)
Synonyms
Description	FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint . .
Accessions	ENST00000524169.5 E5RJV2 ENST00000315985.7 [P63151-2] E5RJV1 A0A590UJJ1 P63151 E5RIY1 ENST00000518397.5 ENST00000521557.5 A0A590UJY3 ENST00000518254.5 ENST00000380737.8 [P63151-1] ENST00000520329.5 E5RFR9 ENST00000660435.1 ENST00000665949.1 E5RHQ2

PPP2R2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review