POLE4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
classical monocyte	22 studies	33% ± 13%	Explore
B cell	19 studies	23% ± 7%	Explore
endothelial cell	18 studies	30% ± 14%	Explore
non-classical monocyte	17 studies	32% ± 15%	Explore
CD4-positive, alpha-beta T cell	17 studies	19% ± 4%	Explore
monocyte	15 studies	27% ± 7%	Explore
endothelial cell of lymphatic vessel	15 studies	28% ± 8%	Explore
CD8-positive, alpha-beta T cell	13 studies	20% ± 5%	Explore
fibroblast	13 studies	24% ± 9%	Explore
pericyte	13 studies	19% ± 3%	Explore
naive B cell	12 studies	19% ± 2%	Explore
memory B cell	12 studies	19% ± 2%	Explore
regulatory T cell	12 studies	18% ± 2%	Explore
macrophage	10 studies	25% ± 10%	Explore
endothelial cell of vascular tree	10 studies	29% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	19% ± 2%	Explore
conventional dendritic cell	9 studies	30% ± 16%	Explore
endothelial cell of artery	9 studies	24% ± 8%	Explore
T cell	9 studies	19% ± 4%	Explore
vein endothelial cell	9 studies	25% ± 5%	Explore
gamma-delta T cell	9 studies	20% ± 9%	Explore
mast cell	8 studies	18% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	20% ± 3%	Explore
natural killer cell	8 studies	23% ± 8%	Explore
smooth muscle cell	7 studies	22% ± 3%	Explore
epithelial cell	7 studies	35% ± 16%	Explore
plasmacytoid dendritic cell	7 studies	25% ± 7%	Explore
basal cell	6 studies	31% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	18% ± 3%	Explore
mature NK T cell	6 studies	18% ± 1%	Explore
retinal rod cell	6 studies	31% ± 12%	Explore
myofibroblast cell	6 studies	23% ± 7%	Explore
dendritic cell	6 studies	30% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	21% ± 6%	Explore
retinal cone cell	5 studies	47% ± 23%	Explore
connective tissue cell	5 studies	20% ± 5%	Explore
ciliated cell	5 studies	28% ± 7%	Explore
T follicular helper cell	5 studies	16% ± 1%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	21% ± 4%	Explore
mucosal invariant T cell	5 studies	17% ± 1%	Explore
mononuclear phagocyte	4 studies	29% ± 11%	Explore
hematopoietic precursor cell	4 studies	28% ± 9%	Explore
goblet cell	4 studies	25% ± 10%	Explore
myeloid cell	4 studies	30% ± 10%	Explore
type II pneumocyte	4 studies	29% ± 17%	Explore
abnormal cell	4 studies	26% ± 8%	Explore
intermediate monocyte	4 studies	40% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	22% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	17% ± 3%	Explore
common myeloid progenitor	3 studies	21% ± 4%	Explore
lymphocyte	3 studies	25% ± 2%	Explore
alveolar macrophage	3 studies	18% ± 0%	Explore
Mueller cell	3 studies	31% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	24% ± 8%	Explore
enterocyte	3 studies	21% ± 3%	Explore
neutrophil	3 studies	20% ± 1%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	20% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	20% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	25% ± 8%	Explore
lung	7 studies	26% ± 7%	Explore
eye	5 studies	27% ± 13%	Explore
intestine	4 studies	22% ± 8%	Explore
kidney	3 studies	16% ± 0%	Explore
lymph node	3 studies	16% ± 0%	Explore
liver	3 studies	30% ± 16%	Explore
breast	3 studies	19% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	1402.36	180 / 180	100%	40.17	430 / 430
uterus	100%	1522.67	170 / 170	100%	82.11	459 / 459
skin	100%	1194.15	1809 / 1809	100%	67.18	471 / 472
intestine	100%	1627.43	966 / 966	99%	47.50	524 / 527
bladder	100%	1792.29	21 / 21	99%	62.75	501 / 504
prostate	100%	1329.45	245 / 245	99%	42.67	499 / 502
lung	100%	1397.88	578 / 578	99%	53.12	1148 / 1155
stomach	100%	1170.61	359 / 359	99%	37.89	284 / 286
breast	100%	2074.10	459 / 459	99%	49.54	1108 / 1118
thymus	100%	1285.64	653 / 653	99%	41.13	598 / 605
kidney	100%	1484.30	89 / 89	99%	33.66	888 / 901
esophagus	100%	1313.03	1445 / 1445	98%	25.54	180 / 183
liver	100%	1008.82	226 / 226	98%	32.72	398 / 406
brain	98%	1402.45	2592 / 2642	99%	43.41	695 / 705
pancreas	96%	505.09	315 / 328	97%	39.68	173 / 178
adrenal gland	100%	1915.45	258 / 258	66%	21.11	151 / 230
adipose	100%	1989.71	1204 / 1204	0%	0	0 / 0
blood vessel	100%	1928.42	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	47.98	80 / 80
lymph node	0%	0	0 / 0	100%	92.02	29 / 29
muscle	100%	1752.90	803 / 803	0%	0	0 / 0
spleen	100%	1484.16	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	58.96	45 / 45
ureter	0%	0	0 / 0	100%	71.23	1 / 1
heart	99%	1021.72	854 / 861	0%	0	0 / 0
peripheral blood	95%	987.40	882 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0071897	Biological process	DNA biosynthetic process
GO_0006261	Biological process	DNA-templated DNA replication
GO_0008622	Cellular component	epsilon DNA polymerase complex
GO_0005654	Cellular component	nucleoplasm
GO_0140672	Cellular component	ATAC complex
GO_0005634	Cellular component	nucleus
GO_0046982	Molecular function	protein heterodimerization activity
GO_0003887	Molecular function	DNA-directed DNA polymerase activity
GO_0003677	Molecular function	DNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	POLE4
Protein name	DNA polymerase epsilon subunit 4 (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12)
Synonyms
Description	FUNCTION: Accessory component of the DNA polymerase epsilon complex . Participates in DNA repair and in chromosomal DNA replication (By similarity). .
Accessions	Q9NR33 ENST00000483063.2

POLE4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review