POLD4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0000731Biological processDNA synthesis involved in DNA repair
GO_0006261Biological processDNA-templated DNA replication
GO_0005654Cellular componentnucleoplasm
GO_0043625Cellular componentdelta DNA polymerase complex
GO_0003887Molecular functionDNA-directed DNA polymerase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePOLD4
Protein namePolymerase (DNA-directed), delta 4
DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12)
DNA polymerase delta 4, accessory subunit
SynonymsPOLDS
DescriptionFUNCTION: As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity . Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system . Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb . Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites . Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival . .

AccessionsENST00000312419.8 [Q9HCU8-1]
Q6NSD7
ENST00000530584.5
ENST00000529704.5
Q9HCU8
ENST00000532830.5
ENST00000531239.2
ENST00000539074.1 [Q9HCU8-2]
E9PL15