PHC3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	21 studies	32% ± 14%	Explore
B cell	14 studies	27% ± 11%	Explore
CD8-positive, alpha-beta T cell	14 studies	20% ± 5%	Explore
astrocyte	14 studies	39% ± 16%	Explore
microglial cell	13 studies	39% ± 13%	Explore
oligodendrocyte precursor cell	12 studies	36% ± 18%	Explore
macrophage	12 studies	34% ± 16%	Explore
oligodendrocyte	12 studies	40% ± 16%	Explore
T cell	11 studies	25% ± 9%	Explore
glutamatergic neuron	10 studies	47% ± 26%	Explore
fibroblast	10 studies	35% ± 13%	Explore
GABAergic neuron	9 studies	45% ± 23%	Explore
CD4-positive, alpha-beta T cell	9 studies	24% ± 6%	Explore
naive B cell	9 studies	19% ± 3%	Explore
adipocyte	9 studies	38% ± 11%	Explore
smooth muscle cell	9 studies	30% ± 8%	Explore
regulatory T cell	8 studies	21% ± 5%	Explore
plasmacytoid dendritic cell	8 studies	22% ± 6%	Explore
natural killer cell	7 studies	25% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	23% ± 6%	Explore
epithelial cell	7 studies	33% ± 15%	Explore
dendritic cell	7 studies	32% ± 12%	Explore
pericyte	7 studies	30% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	21% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	24% ± 8%	Explore
interneuron	6 studies	49% ± 23%	Explore
mucosal invariant T cell	6 studies	21% ± 6%	Explore
myeloid cell	6 studies	26% ± 6%	Explore
mast cell	6 studies	23% ± 7%	Explore
ciliated cell	6 studies	27% ± 10%	Explore
endothelial cell of lymphatic vessel	6 studies	32% ± 12%	Explore
neuron	5 studies	41% ± 20%	Explore
cardiac muscle cell	5 studies	34% ± 9%	Explore
retinal cone cell	5 studies	29% ± 11%	Explore
retina horizontal cell	5 studies	26% ± 8%	Explore
basal cell	5 studies	30% ± 17%	Explore
abnormal cell	5 studies	27% ± 14%	Explore
monocyte	5 studies	31% ± 7%	Explore
club cell	5 studies	30% ± 10%	Explore
type I pneumocyte	5 studies	33% ± 9%	Explore
type II pneumocyte	5 studies	32% ± 8%	Explore
gamma-delta T cell	5 studies	19% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	20% ± 3%	Explore
mature NK T cell	4 studies	20% ± 8%	Explore
granule cell	4 studies	26% ± 7%	Explore
mesothelial cell	4 studies	30% ± 11%	Explore
lymphocyte	4 studies	39% ± 18%	Explore
Mueller cell	4 studies	27% ± 9%	Explore
amacrine cell	4 studies	29% ± 9%	Explore
retinal rod cell	4 studies	40% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	18% ± 1%	Explore
respiratory goblet cell	4 studies	33% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	20% ± 3%	Explore
classical monocyte	3 studies	21% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	21% ± 5%	Explore
non-classical monocyte	3 studies	26% ± 8%	Explore
plasmablast	3 studies	24% ± 6%	Explore
GABAergic interneuron	3 studies	32% ± 3%	Explore
plasma cell	3 studies	41% ± 6%	Explore
vein endothelial cell	3 studies	31% ± 17%	Explore
retinal bipolar neuron	3 studies	22% ± 5%	Explore
GABAergic amacrine cell	3 studies	24% ± 8%	Explore
glycinergic amacrine cell	3 studies	26% ± 5%	Explore
rod bipolar cell	3 studies	27% ± 12%	Explore
endothelial cell of vascular tree	3 studies	30% ± 16%	Explore
hepatocyte	3 studies	44% ± 15%	Explore
ependymal cell	3 studies	41% ± 16%	Explore
alveolar macrophage	3 studies	38% ± 10%	Explore
goblet cell	3 studies	41% ± 25%	Explore
leukocyte	3 studies	51% ± 9%	Explore
transit amplifying cell	3 studies	34% ± 24%	Explore
mural cell	3 studies	36% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	41% ± 22%	Explore
lung	6 studies	26% ± 9%	Explore
peripheral blood	5 studies	21% ± 5%	Explore
eye	5 studies	39% ± 17%	Explore
heart	4 studies	30% ± 5%	Explore
intestine	3 studies	17% ± 1%	Explore
adipose	3 studies	40% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2968.86	1442 / 1445	100%	22.73	183 / 183
ovary	100%	3537.93	180 / 180	100%	11.71	429 / 430
lung	100%	3580.94	578 / 578	100%	15.59	1152 / 1155
breast	100%	3538.42	459 / 459	99%	17.39	1111 / 1118
prostate	100%	2808.86	245 / 245	99%	14.75	498 / 502
thymus	100%	3470.45	653 / 653	99%	14.02	598 / 605
stomach	100%	2517.08	359 / 359	98%	13.55	279 / 286
kidney	100%	1574.90	89 / 89	97%	13.60	878 / 901
uterus	100%	3405.58	170 / 170	97%	11.77	445 / 459
pancreas	99%	1619.47	325 / 328	98%	10.56	174 / 178
intestine	100%	3238.05	966 / 966	97%	10.34	510 / 527
bladder	100%	3269.29	21 / 21	96%	10.45	486 / 504
brain	92%	1238.19	2434 / 2642	99%	10.66	701 / 705
adrenal gland	100%	2135.74	258 / 258	91%	6.73	210 / 230
skin	100%	3114.47	1809 / 1809	87%	8.14	412 / 472
liver	97%	973.96	220 / 226	65%	4.00	262 / 406
adipose	100%	3416.22	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3713.31	1335 / 1335	0%	0	0 / 0
muscle	100%	1943.66	803 / 803	0%	0	0 / 0
spleen	100%	2533.48	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.50	1 / 1
tonsil	0%	0	0 / 0	96%	14.30	43 / 45
heart	93%	1653.78	805 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	8.91	27 / 29
peripheral blood	89%	2123.71	824 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	45%	2.44	36 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0031519	Cellular component	PcG protein complex
GO_0035102	Cellular component	PRC1 complex
GO_0005654	Cellular component	nucleoplasm
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0042393	Molecular function	histone binding
GO_0003682	Molecular function	chromatin binding

IV. Literature review

[source]

Gene name	PHC3
Protein name	Polyhomeotic homolog 3 (Polyhomeotic like 3 (Drosophila), isoform CRA_a) PHC3 protein Polyhomeotic homolog 3 Polyhomeotic homolog 3 (cDNA FLJ57195, highly similar to Polyhomeotic-like protein 3) Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3)
Synonyms	PH3 EDR3 hCG_2021666
Description	FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. .
Accessions	B4DTC4 E7EX82 G5E9U7 ENST00000472330.5 ENST00000467570.5 F8WDA4 ENST00000497658.5 [Q8NDX5-5] C9JYH7 ENST00000494943.5 [Q8NDX5-1] ENST00000479467.5 H7C528 C9J6H0 Q8NDX5 ENST00000481639.1 ENST00000495893.7 [Q8NDX5-7] ENST00000484068.5 ENST00000475729.5 H7C4H9 A5YM43 ENST00000486042.1 ENST00000484931.5 C9JAU4 ENST00000466189.5

PHC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review