PCMTD1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	39 studies	31% ± 11%	Explore
fibroblast	29 studies	24% ± 8%	Explore
natural killer cell	21 studies	20% ± 5%	Explore
B cell	19 studies	24% ± 6%	Explore
smooth muscle cell	19 studies	23% ± 6%	Explore
macrophage	16 studies	28% ± 14%	Explore
pericyte	15 studies	24% ± 6%	Explore
naive B cell	14 studies	19% ± 2%	Explore
endothelial cell of lymphatic vessel	12 studies	25% ± 8%	Explore
glutamatergic neuron	12 studies	43% ± 25%	Explore
capillary endothelial cell	12 studies	22% ± 5%	Explore
endothelial cell of artery	12 studies	26% ± 6%	Explore
astrocyte	12 studies	33% ± 14%	Explore
memory B cell	12 studies	18% ± 2%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	23% ± 4%	Explore
microglial cell	11 studies	30% ± 11%	Explore
endothelial cell of vascular tree	11 studies	23% ± 12%	Explore
oligodendrocyte	11 studies	30% ± 11%	Explore
plasmacytoid dendritic cell	11 studies	26% ± 8%	Explore
type I pneumocyte	10 studies	28% ± 9%	Explore
GABAergic neuron	10 studies	47% ± 22%	Explore
oligodendrocyte precursor cell	10 studies	34% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	18% ± 2%	Explore
plasma cell	9 studies	28% ± 9%	Explore
epithelial cell	9 studies	39% ± 20%	Explore
basal cell	9 studies	31% ± 15%	Explore
ciliated cell	9 studies	30% ± 12%	Explore
adipocyte	9 studies	30% ± 9%	Explore
myofibroblast cell	8 studies	23% ± 8%	Explore
gamma-delta T cell	8 studies	23% ± 11%	Explore
T cell	7 studies	21% ± 3%	Explore
non-classical monocyte	7 studies	22% ± 7%	Explore
mature NK T cell	7 studies	20% ± 5%	Explore
neuron	7 studies	43% ± 21%	Explore
amacrine cell	7 studies	29% ± 11%	Explore
vein endothelial cell	7 studies	26% ± 11%	Explore
regulatory T cell	7 studies	19% ± 4%	Explore
connective tissue cell	7 studies	21% ± 4%	Explore
CD8-positive, alpha-beta T cell	6 studies	19% ± 4%	Explore
interneuron	6 studies	54% ± 17%	Explore
myeloid cell	6 studies	24% ± 6%	Explore
club cell	6 studies	29% ± 9%	Explore
retina horizontal cell	6 studies	29% ± 9%	Explore
dendritic cell	6 studies	28% ± 10%	Explore
Mueller cell	6 studies	40% ± 9%	Explore
type II pneumocyte	6 studies	24% ± 6%	Explore
CD4-positive, alpha-beta T cell	5 studies	20% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	20% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	19% ± 3%	Explore
kidney loop of Henle epithelial cell	5 studies	22% ± 7%	Explore
retinal bipolar neuron	5 studies	28% ± 8%	Explore
platelet	5 studies	21% ± 6%	Explore
brush cell	5 studies	30% ± 13%	Explore
cardiac muscle cell	5 studies	35% ± 7%	Explore
lymphocyte	5 studies	27% ± 10%	Explore
respiratory goblet cell	5 studies	29% ± 11%	Explore
innate lymphoid cell	5 studies	22% ± 3%	Explore
monocyte	5 studies	26% ± 6%	Explore
goblet cell	5 studies	32% ± 23%	Explore
secretory cell	4 studies	27% ± 9%	Explore
leukocyte	4 studies	23% ± 8%	Explore
conventional dendritic cell	4 studies	28% ± 7%	Explore
abnormal cell	4 studies	31% ± 15%	Explore
granule cell	4 studies	29% ± 5%	Explore
progenitor cell	4 studies	27% ± 3%	Explore
retinal ganglion cell	4 studies	41% ± 16%	Explore
mucosal invariant T cell	4 studies	18% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	18% ± 1%	Explore
enteroendocrine cell	4 studies	23% ± 10%	Explore
classical monocyte	3 studies	23% ± 5%	Explore
glomerular endothelial cell	3 studies	22% ± 3%	Explore
GABAergic interneuron	3 studies	39% ± 2%	Explore
glial cell	3 studies	22% ± 5%	Explore
retinal cone cell	3 studies	18% ± 2%	Explore
mononuclear phagocyte	3 studies	22% ± 6%	Explore
GABAergic amacrine cell	3 studies	35% ± 9%	Explore
OFF-bipolar cell	3 studies	34% ± 5%	Explore
ON-bipolar cell	3 studies	26% ± 5%	Explore
glycinergic amacrine cell	3 studies	24% ± 3%	Explore
rod bipolar cell	3 studies	53% ± 6%	Explore
hepatocyte	3 studies	27% ± 9%	Explore
muscle cell	3 studies	37% ± 18%	Explore
ependymal cell	3 studies	35% ± 16%	Explore
hematopoietic stem cell	3 studies	22% ± 5%	Explore
adventitial cell	3 studies	20% ± 4%	Explore
alveolar macrophage	3 studies	29% ± 9%	Explore
chondrocyte	3 studies	25% ± 1%	Explore
T follicular helper cell	3 studies	16% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 9%	Explore
mast cell	3 studies	22% ± 7%	Explore
double negative thymocyte	3 studies	24% ± 12%	Explore
podocyte	3 studies	44% ± 7%	Explore
mucus secreting cell	3 studies	26% ± 7%	Explore
renal principal cell	3 studies	28% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	37% ± 20%	Explore
lung	12 studies	24% ± 8%	Explore
eye	7 studies	29% ± 12%	Explore
heart	5 studies	26% ± 6%	Explore
liver	4 studies	29% ± 14%	Explore
adipose	4 studies	26% ± 6%	Explore
peripheral blood	3 studies	28% ± 6%	Explore
uterus	3 studies	28% ± 11%	Explore
intestine	3 studies	24% ± 7%	Explore
kidney	3 studies	27% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	4648.45	258 / 258	100%	29.02	230 / 230
prostate	100%	4789.40	245 / 245	100%	47.12	502 / 502
breast	100%	4667.68	459 / 459	100%	55.82	1117 / 1118
lung	100%	3916.72	578 / 578	100%	29.15	1153 / 1155
thymus	100%	5169.77	653 / 653	100%	40.93	602 / 605
esophagus	100%	5011.84	1445 / 1445	99%	26.22	182 / 183
pancreas	100%	5682.20	328 / 328	99%	30.94	177 / 178
kidney	100%	3073.73	89 / 89	99%	30.76	892 / 901
brain	99%	2318.58	2626 / 2642	100%	18.87	702 / 705
ovary	100%	6058.23	180 / 180	99%	23.46	424 / 430
uterus	100%	5077.45	170 / 170	98%	24.71	452 / 459
bladder	100%	4864.38	21 / 21	98%	27.56	494 / 504
intestine	100%	4938.21	966 / 966	96%	22.79	507 / 527
stomach	100%	3454.34	359 / 359	94%	23.28	270 / 286
liver	98%	1485.71	222 / 226	92%	13.68	372 / 406
skin	100%	3241.31	1805 / 1809	86%	17.43	404 / 472
blood vessel	100%	4470.90	1335 / 1335	0%	0	0 / 0
muscle	100%	5781.29	803 / 803	0%	0	0 / 0
spleen	100%	5349.62	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	22.27	1 / 1
adipose	100%	4449.62	1203 / 1204	0%	0	0 / 0
heart	98%	3242.23	846 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	19.69	44 / 45
lymph node	0%	0	0 / 0	93%	15.66	27 / 29
peripheral blood	72%	1348.67	667 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	69%	16.44	55 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016567	Biological process	protein ubiquitination
GO_0031466	Cellular component	Cul5-RING ubiquitin ligase complex
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_1990756	Molecular function	ubiquitin-like ligase-substrate adaptor activity
GO_0004719	Molecular function	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO_0005515	Molecular function	protein binding
GO_0008757	Molecular function	S-adenosylmethionine-dependent methyltransferase activity

IV. Literature review

[source]

Gene name	PCMTD1
Protein name	Protein-L-isoaspartate O-methyltransferase domain-containing protein 1
Synonyms
Description	FUNCTION: Substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Specifically binds to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but does not display methyltransferase activity . May provide an alternate maintenance pathway for modified proteins by acting as a damage-specific E3 ubiquitin ligase adaptor protein . .
Accessions	H0YBU4 ENST00000519554.5 Q96MG8 ENST00000521344.1 ENST00000544451.2 [Q96MG8-2] E5RGG7 ENST00000360540.9 [Q96MG8-1] ENST00000522514.6 [Q96MG8-1]

PCMTD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review