NPEPPS | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	25 studies	27% ± 12%	Explore
endothelial cell	23 studies	30% ± 15%	Explore
astrocyte	16 studies	36% ± 17%	Explore
epithelial cell	15 studies	37% ± 22%	Explore
smooth muscle cell	14 studies	22% ± 6%	Explore
ciliated cell	14 studies	29% ± 12%	Explore
macrophage	13 studies	30% ± 12%	Explore
glutamatergic neuron	12 studies	45% ± 24%	Explore
endothelial cell of lymphatic vessel	11 studies	36% ± 13%	Explore
basal cell	11 studies	31% ± 18%	Explore
B cell	11 studies	21% ± 5%	Explore
microglial cell	11 studies	31% ± 11%	Explore
oligodendrocyte precursor cell	11 studies	37% ± 16%	Explore
oligodendrocyte	11 studies	32% ± 13%	Explore
natural killer cell	10 studies	19% ± 3%	Explore
type I pneumocyte	10 studies	36% ± 12%	Explore
GABAergic neuron	10 studies	45% ± 22%	Explore
pericyte	10 studies	25% ± 10%	Explore
adipocyte	10 studies	34% ± 9%	Explore
classical monocyte	9 studies	21% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	19% ± 2%	Explore
neuron	8 studies	36% ± 17%	Explore
retinal cone cell	8 studies	39% ± 12%	Explore
myeloid cell	8 studies	24% ± 7%	Explore
amacrine cell	7 studies	29% ± 11%	Explore
retinal ganglion cell	7 studies	56% ± 25%	Explore
regulatory T cell	7 studies	18% ± 2%	Explore
type II pneumocyte	7 studies	28% ± 9%	Explore
T cell	7 studies	20% ± 4%	Explore
connective tissue cell	7 studies	20% ± 3%	Explore
respiratory goblet cell	6 studies	32% ± 11%	Explore
secretory cell	6 studies	25% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	19% ± 2%	Explore
retinal rod cell	6 studies	28% ± 9%	Explore
interneuron	6 studies	52% ± 21%	Explore
naive B cell	6 studies	21% ± 2%	Explore
club cell	6 studies	32% ± 8%	Explore
myofibroblast cell	6 studies	31% ± 12%	Explore
dendritic cell	6 studies	29% ± 10%	Explore
monocyte	6 studies	27% ± 9%	Explore
goblet cell	6 studies	29% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	17% ± 1%	Explore
non-classical monocyte	5 studies	24% ± 8%	Explore
retinal bipolar neuron	5 studies	30% ± 4%	Explore
CD8-positive, alpha-beta T cell	5 studies	19% ± 3%	Explore
mast cell	5 studies	24% ± 7%	Explore
retina horizontal cell	5 studies	29% ± 12%	Explore
cardiac muscle cell	5 studies	26% ± 3%	Explore
mucosal invariant T cell	5 studies	18% ± 1%	Explore
lymphocyte	5 studies	27% ± 6%	Explore
gamma-delta T cell	5 studies	22% ± 9%	Explore
plasmacytoid dendritic cell	5 studies	21% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	18% ± 1%	Explore
squamous epithelial cell	4 studies	53% ± 22%	Explore
CD4-positive, alpha-beta T cell	4 studies	18% ± 3%	Explore
granule cell	4 studies	31% ± 6%	Explore
memory B cell	4 studies	17% ± 2%	Explore
precursor B cell	4 studies	21% ± 2%	Explore
mesothelial cell	4 studies	28% ± 6%	Explore
OFF-bipolar cell	4 studies	47% ± 12%	Explore
ON-bipolar cell	4 studies	50% ± 12%	Explore
endothelial cell of artery	4 studies	17% ± 2%	Explore
muscle cell	4 studies	33% ± 21%	Explore
abnormal cell	4 studies	32% ± 16%	Explore
kidney loop of Henle epithelial cell	4 studies	20% ± 5%	Explore
renal principal cell	4 studies	25% ± 7%	Explore
ionocyte	3 studies	37% ± 1%	Explore
hematopoietic precursor cell	3 studies	28% ± 11%	Explore
GABAergic interneuron	3 studies	38% ± 3%	Explore
glial cell	3 studies	26% ± 2%	Explore
progenitor cell	3 studies	28% ± 6%	Explore
plasma cell	3 studies	32% ± 8%	Explore
immature B cell	3 studies	19% ± 3%	Explore
retinal pigment epithelial cell	3 studies	40% ± 24%	Explore
mononuclear phagocyte	3 studies	25% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
vein endothelial cell	3 studies	30% ± 17%	Explore
GABAergic amacrine cell	3 studies	38% ± 12%	Explore
Mueller cell	3 studies	25% ± 13%	Explore
glycinergic amacrine cell	3 studies	30% ± 6%	Explore
rod bipolar cell	3 studies	45% ± 13%	Explore
T follicular helper cell	3 studies	17% ± 2%	Explore
endothelial cell of vascular tree	3 studies	28% ± 14%	Explore
hepatocyte	3 studies	41% ± 20%	Explore
ependymal cell	3 studies	44% ± 13%	Explore
enteroendocrine cell	3 studies	23% ± 5%	Explore
adventitial cell	3 studies	25% ± 6%	Explore
alveolar macrophage	3 studies	36% ± 10%	Explore
group 3 innate lymphoid cell	3 studies	23% ± 5%	Explore
transit amplifying cell	3 studies	42% ± 34%	Explore
brush cell	3 studies	21% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	18% ± 1%	Explore
epithelial cell of proximal tubule	3 studies	19% ± 3%	Explore
renal alpha-intercalated cell	3 studies	27% ± 9%	Explore
mucus secreting cell	3 studies	32% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	39% ± 19%	Explore
eye	10 studies	30% ± 16%	Explore
lung	10 studies	28% ± 9%	Explore
peripheral blood	5 studies	23% ± 5%	Explore
heart	4 studies	25% ± 2%	Explore
adipose	4 studies	29% ± 9%	Explore
placenta	3 studies	24% ± 6%	Explore
liver	3 studies	35% ± 16%	Explore
intestine	3 studies	22% ± 6%	Explore
kidney	3 studies	26% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	9067.67	1445 / 1445	100%	24.85	183 / 183
lung	100%	5598.15	577 / 578	100%	24.01	1155 / 1155
bladder	100%	6010.10	21 / 21	100%	21.98	503 / 504
ovary	100%	6677.36	180 / 180	100%	17.93	429 / 430
breast	100%	5545.03	459 / 459	100%	29.53	1114 / 1118
intestine	100%	6514.68	966 / 966	99%	18.25	524 / 527
prostate	100%	5081.96	245 / 245	99%	22.77	499 / 502
uterus	100%	5985.12	170 / 170	99%	23.07	456 / 459
brain	99%	5019.05	2620 / 2642	100%	28.68	705 / 705
stomach	100%	4610.10	359 / 359	99%	17.99	283 / 286
pancreas	100%	3171.78	328 / 328	99%	18.54	176 / 178
thymus	100%	4949.79	652 / 653	99%	20.90	599 / 605
kidney	100%	4181.24	89 / 89	99%	21.28	889 / 901
skin	100%	7474.94	1809 / 1809	97%	20.23	460 / 472
adrenal gland	100%	7939.13	258 / 258	90%	11.22	207 / 230
liver	97%	2025.10	219 / 226	81%	8.61	330 / 406
adipose	100%	5539.02	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	14.38	29 / 29
muscle	100%	11231.00	803 / 803	0%	0	0 / 0
spleen	100%	5279.02	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	19.57	45 / 45
ureter	0%	0	0 / 0	100%	7.61	1 / 1
blood vessel	100%	5266.33	1334 / 1335	0%	0	0 / 0
heart	94%	3560.57	811 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	93%	12.42	74 / 80
peripheral blood	92%	4598.84	859 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1903955	Biological process	positive regulation of protein targeting to mitochondrion
GO_0000209	Biological process	protein polyubiquitination
GO_0006508	Biological process	proteolysis
GO_0043171	Biological process	peptide catabolic process
GO_0071456	Biological process	cellular response to hypoxia
GO_0005615	Cellular component	extracellular space
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0042277	Molecular function	peptide binding
GO_0070006	Molecular function	metalloaminopeptidase activity
GO_0008270	Molecular function	zinc ion binding
GO_0004177	Molecular function	aminopeptidase activity

IV. Literature review

[source]

Gene name	NPEPPS
Protein name	Aminopeptidase (EC 3.4.11.-) Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S) Aminopeptidase puromycin sensitive
Synonyms	PSA
Description	FUNCTION: Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. .
Accessions	ENST00000527298.5 ENST00000528565.2 A0A7I2V3W8 ENST00000678902.1 A0A7I2V5M8 A0A7I2YQS3 ENST00000677370.1 E9PJY4 ENST00000678909.1 E9PLK3 ENST00000677120.1 [P55786-1] ENST00000677226.1 ENST00000530173.6 ENST00000322157.9 [P55786-1] A0A7I2V604 ENST00000532729.6 ENST00000700497.1 A0A7I2V5D4 ENST00000526247.6 ENST00000677664.1 E9PP11 E9PPZ2 ENST00000525048.5 ENST00000678461.1 ENST00000534691.1 E9PPD4 ENST00000530514.6 A0A7I2V389 H0YCQ5 E9PJF9 E9PI82 H0YDG0 P55786 A0A7I2V3D7 ENST00000525007.5 ENST00000677710.1 A0A8V8TQ95 ENST00000678262.1

NPEPPS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review