NOP56 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006364Biological processrRNA processing
GO_0042274Biological processribosomal small subunit biogenesis
GO_0005732Cellular componentsno(s)RNA-containing ribonucleoprotein complex
GO_0005730Cellular componentnucleolus
GO_0070761Cellular componentpre-snoRNP complex
GO_0001650Cellular componentfibrillar center
GO_0005654Cellular componentnucleoplasm
GO_0031428Cellular componentbox C/D methylation guide snoRNP complex
GO_0032040Cellular componentsmall-subunit processome
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0045296Molecular functioncadherin binding
GO_0030515Molecular functionsnoRNA binding
GO_0005515Molecular functionprotein binding
GO_1990226Molecular functionhistone methyltransferase binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNOP56
Protein nameNucleolar protein 5A
Nucleolar protein 56 (Nucleolar protein 5A)
NOP56 protein
SynonymsNOL5A
DescriptionFUNCTION: Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs . Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome . .

AccessionsH0Y653
Q5JXT2
Q9BSN3
H0YDU4
ENST00000467196.5
ENST00000329276.10
ENST00000415272.2
ENST00000651302.1
A0PJ92
O00567
ENST00000445139.1
A0A494C128