NME1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0006897Biological processendocytosis
GO_0006228Biological processUTP biosynthetic process
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0042981Biological processregulation of apoptotic process
GO_0006259Biological processDNA metabolic process
GO_0030154Biological processcell differentiation
GO_0043388Biological processpositive regulation of DNA binding
GO_0006183Biological processGTP biosynthetic process
GO_0007595Biological processlactation
GO_0007399Biological processnervous system development
GO_0006241Biological processCTP biosynthetic process
GO_0032587Cellular componentruffle membrane
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004536Molecular functionDNA nuclease activity
GO_0004550Molecular functionnucleoside diphosphate kinase activity
GO_0043024Molecular functionribosomal small subunit binding
GO_0042802Molecular functionidentical protein binding
GO_0000287Molecular functionmagnesium ion binding
GO_0008408Molecular function3'-5' exonuclease activity
GO_0005525Molecular functionGTP binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNME1
Protein nameNucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein)
nucleoside-diphosphate kinase (EC 2.7.4.6)
SynonymsNM23
NDPKA
DescriptionFUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. .

AccessionsC9K028
ENST00000456492.1
ENST00000013034.3 [P15531-2]
E5RHP0
ENST00000393196.8 [P15531-1]
E7ERL0
ENST00000480143.5
ENST00000511355.5
ENST00000475573.5
ENST00000336097.7 [P15531-2]
P15531