NDUFS4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	35 studies	30% ± 13%	Explore
endothelial cell	32 studies	28% ± 11%	Explore
pericyte	26 studies	27% ± 8%	Explore
smooth muscle cell	25 studies	28% ± 10%	Explore
basal cell	16 studies	33% ± 16%	Explore
endothelial cell of lymphatic vessel	15 studies	24% ± 9%	Explore
epithelial cell	15 studies	38% ± 18%	Explore
myofibroblast cell	15 studies	28% ± 11%	Explore
connective tissue cell	15 studies	35% ± 10%	Explore
conventional dendritic cell	13 studies	29% ± 14%	Explore
macrophage	13 studies	25% ± 8%	Explore
progenitor cell	10 studies	28% ± 11%	Explore
monocyte	10 studies	21% ± 4%	Explore
endothelial cell of vascular tree	10 studies	23% ± 5%	Explore
astrocyte	9 studies	35% ± 15%	Explore
natural killer cell	8 studies	21% ± 5%	Explore
abnormal cell	8 studies	33% ± 16%	Explore
neuron	8 studies	41% ± 16%	Explore
mesothelial cell	8 studies	31% ± 15%	Explore
ciliated cell	8 studies	36% ± 11%	Explore
oligodendrocyte precursor cell	8 studies	31% ± 11%	Explore
classical monocyte	7 studies	25% ± 10%	Explore
capillary endothelial cell	7 studies	20% ± 4%	Explore
epithelial cell of proximal tubule	7 studies	32% ± 10%	Explore
enterocyte	7 studies	24% ± 6%	Explore
goblet cell	7 studies	30% ± 14%	Explore
vein endothelial cell	7 studies	22% ± 6%	Explore
type I pneumocyte	7 studies	27% ± 8%	Explore
retinal rod cell	7 studies	26% ± 7%	Explore
mast cell	7 studies	24% ± 11%	Explore
adipocyte	7 studies	24% ± 7%	Explore
GABAergic neuron	7 studies	39% ± 19%	Explore
oligodendrocyte	7 studies	30% ± 9%	Explore
hematopoietic precursor cell	6 studies	32% ± 17%	Explore
secretory cell	6 studies	31% ± 16%	Explore
kidney loop of Henle epithelial cell	6 studies	34% ± 11%	Explore
renal alpha-intercalated cell	6 studies	47% ± 11%	Explore
microglial cell	6 studies	25% ± 5%	Explore
hematopoietic stem cell	6 studies	22% ± 5%	Explore
myeloid cell	6 studies	24% ± 10%	Explore
club cell	6 studies	28% ± 8%	Explore
type II pneumocyte	6 studies	26% ± 10%	Explore
retinal cone cell	6 studies	34% ± 16%	Explore
cardiac muscle cell	6 studies	30% ± 4%	Explore
dendritic cell	6 studies	35% ± 20%	Explore
plasmacytoid dendritic cell	6 studies	26% ± 9%	Explore
non-classical monocyte	5 studies	32% ± 9%	Explore
endothelial cell of artery	5 studies	22% ± 5%	Explore
enteroendocrine cell	5 studies	33% ± 14%	Explore
intestinal crypt stem cell	5 studies	26% ± 8%	Explore
glial cell	5 studies	29% ± 19%	Explore
retinal ganglion cell	5 studies	53% ± 25%	Explore
retina horizontal cell	5 studies	26% ± 12%	Explore
Mueller cell	5 studies	25% ± 6%	Explore
hepatocyte	5 studies	37% ± 24%	Explore
glutamatergic neuron	5 studies	51% ± 22%	Explore
transit amplifying cell	5 studies	26% ± 13%	Explore
interneuron	5 studies	39% ± 22%	Explore
ionocyte	4 studies	26% ± 10%	Explore
pancreatic A cell	4 studies	37% ± 12%	Explore
plasma cell	4 studies	30% ± 13%	Explore
amacrine cell	4 studies	38% ± 9%	Explore
mononuclear phagocyte	4 studies	27% ± 11%	Explore
OFF-bipolar cell	4 studies	30% ± 18%	Explore
ON-bipolar cell	4 studies	32% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	21% ± 5%	Explore
type B pancreatic cell	3 studies	39% ± 4%	Explore
B cell	3 studies	23% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	19% ± 3%	Explore
CD4-positive, alpha-beta T cell	3 studies	23% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	16% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	45% ± 9%	Explore
T cell	3 studies	29% ± 13%	Explore
leukocyte	3 studies	22% ± 3%	Explore
neural crest cell	3 studies	37% ± 8%	Explore
GABAergic interneuron	3 studies	19% ± 3%	Explore
brush cell	3 studies	28% ± 10%	Explore
duct epithelial cell	3 studies	18% ± 0%	Explore
serous secreting cell	3 studies	23% ± 5%	Explore
lymphocyte	3 studies	25% ± 7%	Explore
glycinergic amacrine cell	3 studies	23% ± 4%	Explore
rod bipolar cell	3 studies	30% ± 2%	Explore
erythroblast	3 studies	34% ± 13%	Explore
muscle cell	3 studies	40% ± 14%	Explore
regulatory T cell	3 studies	20% ± 4%	Explore
myoepithelial cell	3 studies	30% ± 4%	Explore
granulocyte monocyte progenitor cell	3 studies	31% ± 9%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	52% ± 16%	Explore
keratinocyte	3 studies	16% ± 0%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
eye	10 studies	27% ± 10%	Explore
lung	10 studies	31% ± 12%	Explore
brain	9 studies	36% ± 18%	Explore
kidney	8 studies	28% ± 8%	Explore
intestine	8 studies	27% ± 12%	Explore
peripheral blood	6 studies	22% ± 8%	Explore
heart	6 studies	20% ± 3%	Explore
liver	6 studies	26% ± 14%	Explore
uterus	4 studies	30% ± 12%	Explore
pancreas	3 studies	40% ± 3%	Explore
skin	3 studies	18% ± 2%	Explore
thymus	3 studies	33% ± 12%	Explore
breast	3 studies	21% ± 6%	Explore
adipose	3 studies	20% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1965.85	1445 / 1445	100%	61.63	183 / 183
ovary	100%	2336.49	180 / 180	100%	85.42	430 / 430
stomach	100%	1642.12	359 / 359	100%	81.03	286 / 286
uterus	100%	1951.43	170 / 170	100%	102.71	459 / 459
brain	100%	1745.07	2639 / 2642	100%	118.38	705 / 705
breast	100%	2307.27	459 / 459	100%	104.64	1116 / 1118
intestine	100%	2180.63	966 / 966	100%	89.51	526 / 527
prostate	100%	1700.75	245 / 245	100%	92.85	501 / 502
kidney	100%	2467.34	89 / 89	100%	119.20	899 / 901
thymus	100%	1709.96	652 / 653	100%	116.30	604 / 605
lung	99%	1498.46	575 / 578	100%	82.98	1155 / 1155
skin	100%	2089.81	1809 / 1809	99%	89.61	468 / 472
liver	99%	1166.64	224 / 226	100%	115.76	405 / 406
bladder	100%	1905.19	21 / 21	99%	88.89	498 / 504
adrenal gland	100%	2017.75	258 / 258	98%	118.42	225 / 230
pancreas	95%	663.90	312 / 328	100%	82.13	178 / 178
adipose	100%	2244.75	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2290.49	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	100.66	29 / 29
muscle	100%	4045.14	803 / 803	0%	0	0 / 0
spleen	100%	1112.90	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	118.43	45 / 45
ureter	0%	0	0 / 0	100%	37.03	1 / 1
heart	99%	2751.04	849 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	98%	98.00	78 / 80
peripheral blood	33%	582.52	309 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007420	Biological process	brain development
GO_0051591	Biological process	response to cAMP
GO_0048146	Biological process	positive regulation of fibroblast proliferation
GO_0009060	Biological process	aerobic respiration
GO_0001932	Biological process	regulation of protein phosphorylation
GO_0045333	Biological process	cellular respiration
GO_0006120	Biological process	mitochondrial electron transport, NADH to ubiquinone
GO_0042776	Biological process	proton motive force-driven mitochondrial ATP synthesis
GO_0055085	Biological process	transmembrane transport
GO_0072593	Biological process	reactive oxygen species metabolic process
GO_0032981	Biological process	mitochondrial respiratory chain complex I assembly
GO_0045271	Cellular component	respiratory chain complex I
GO_0005739	Cellular component	mitochondrion
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0008137	Molecular function	NADH dehydrogenase (ubiquinone) activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NDUFS4
Protein name	NADH dehydrogenase Fe-S protein 4 18kDa (NADH-coenzyme Q reductase) isoform 2 (NADH:ubiquinone oxidoreductase subunit S4) NADH:ubiquinone oxidoreductase subunit S4 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (CI-18 kDa) (Complex I-AQDQ) (CI-AQDQ) (NADH-ubiquinone oxidoreductase 18 kDa subunit) NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (NADH-ubiquinone oxidoreductase 18 kDa subunit)
Synonyms	hCG_39566
Description	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. . FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. . FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. .
Accessions	ENST00000502423.5 ENST00000296684.10 A0A0S2Z433 ENST00000507026.5 D6R916 D6RI09 O43181 ENST00000506765.1 ENST00000506974.5 D6REP1 H0Y9M8

NDUFS4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review