NAXE report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010874Biological processregulation of cholesterol efflux
GO_0016525Biological processnegative regulation of angiogenesis
GO_0046496Biological processnicotinamide nucleotide metabolic process
GO_0006869Biological processlipid transport
GO_0031580Biological processmembrane raft distribution
GO_0002040Biological processsprouting angiogenesis
GO_0044297Cellular componentcell body
GO_0005615Cellular componentextracellular space
GO_0005929Cellular componentcilium
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0005759Cellular componentmitochondrial matrix
GO_0052856Molecular functionNADHX epimerase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0000166Molecular functionnucleotide binding
GO_0052857Molecular functionNADPHX epimerase activity

IV. Literature review

[source]
Gene nameNAXE
Protein nameNAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)
NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) (NAXE) (YjeF N-terminal domain-containing protein 1) (YjeF_N1)
NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase)
SynonymsYJEFN1
APOA1BP
AIBP
DescriptionFUNCTION: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) . This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity). Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis . .

FUNCTION: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. .

FUNCTION: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. .

AccessionsA0A7P0TAG8
Q6PGN4
ENST00000680004.1 [Q8NCW5-1]
ENST00000680661.1
B4DP80
ENST00000681054.1 [Q8NCW5-1]
Q5T3I3
ENST00000680087.1
Q8NCW5
ENST00000680269.1 [Q8NCW5-1]
A0A7P0Z426
ENST00000679369.1
A0A7P0T9Y2
ENST00000368234.7
ENST00000368233.3
ENST00000368235.8 [Q8NCW5-1]
ENST00000679702.1 [Q8NCW5-1]
ENST00000681523.1 [Q8NCW5-1]
Q5T3I4
A0A7P0TA18
ENST00000681734.1