MED13L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0016592Cellular componentmediator complex
GO_0003712Molecular functiontranscription coregulator activity

IV. Literature review

[source]
Gene nameMED13L
Protein nameMediator complex subunit 13L
Mediator of RNA polymerase II transcription subunit 13
Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like)
SynonymsTRAP240L
PROSIT240
KIAA1025
THRAP2
DescriptionFUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

AccessionsA0A3B3IS46
ENST00000649607.1
ENST00000649775.1
H0YHC1
ENST00000549786.2
A0A3B3IRS4
A0A3B3IRX3
F8VRB8
A0A3B3IS48
A0A3B3IS36
Q71F56
ENST00000650226.1
ENST00000647567.1
ENST00000551197.2
ENST00000281928.9
ENST00000548743.2