LYPLA1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	22 studies	25% ± 10%	Explore
B cell	18 studies	26% ± 8%	Explore
natural killer cell	18 studies	22% ± 5%	Explore
macrophage	16 studies	22% ± 6%	Explore
memory B cell	14 studies	21% ± 4%	Explore
naive B cell	14 studies	19% ± 4%	Explore
non-classical monocyte	14 studies	28% ± 13%	Explore
regulatory T cell	14 studies	22% ± 5%	Explore
conventional dendritic cell	13 studies	26% ± 15%	Explore
classical monocyte	12 studies	25% ± 11%	Explore
monocyte	12 studies	20% ± 6%	Explore
plasmacytoid dendritic cell	12 studies	27% ± 10%	Explore
endothelial cell of lymphatic vessel	12 studies	21% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	22% ± 4%	Explore
CD8-positive, alpha-beta T cell	10 studies	24% ± 6%	Explore
epithelial cell	10 studies	38% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	23% ± 4%	Explore
retinal cone cell	8 studies	42% ± 25%	Explore
ciliated cell	8 studies	32% ± 13%	Explore
CD4-positive, alpha-beta T cell	7 studies	27% ± 5%	Explore
dendritic cell	7 studies	33% ± 19%	Explore
basal cell	7 studies	34% ± 13%	Explore
hematopoietic precursor cell	6 studies	33% ± 12%	Explore
mature NK T cell	6 studies	18% ± 2%	Explore
gamma-delta T cell	6 studies	24% ± 14%	Explore
microglial cell	6 studies	25% ± 5%	Explore
myeloid cell	6 studies	28% ± 9%	Explore
retinal rod cell	6 studies	29% ± 12%	Explore
plasma cell	5 studies	29% ± 12%	Explore
plasmablast	5 studies	42% ± 20%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	23% ± 6%	Explore
kidney loop of Henle epithelial cell	5 studies	24% ± 8%	Explore
T cell	5 studies	18% ± 3%	Explore
lymphocyte	5 studies	21% ± 4%	Explore
precursor B cell	5 studies	27% ± 6%	Explore
brush cell	5 studies	32% ± 16%	Explore
endothelial cell of vascular tree	5 studies	19% ± 3%	Explore
abnormal cell	5 studies	29% ± 9%	Explore
secretory cell	5 studies	27% ± 10%	Explore
neuron	5 studies	35% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	17% ± 2%	Explore
connective tissue cell	4 studies	18% ± 4%	Explore
epithelial cell of proximal tubule	4 studies	18% ± 2%	Explore
leukocyte	4 studies	23% ± 6%	Explore
vein endothelial cell	4 studies	22% ± 5%	Explore
pro-B cell	4 studies	23% ± 1%	Explore
immature B cell	4 studies	22% ± 4%	Explore
T follicular helper cell	4 studies	18% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	22% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	22% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	24% ± 3%	Explore
hepatocyte	4 studies	39% ± 24%	Explore
GABAergic neuron	4 studies	40% ± 14%	Explore
glutamatergic neuron	4 studies	43% ± 13%	Explore
hematopoietic stem cell	4 studies	27% ± 7%	Explore
mast cell	4 studies	30% ± 9%	Explore
goblet cell	4 studies	27% ± 8%	Explore
astrocyte	4 studies	22% ± 6%	Explore
mucosal invariant T cell	4 studies	17% ± 1%	Explore
squamous epithelial cell	3 studies	43% ± 20%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	21% ± 6%	Explore
pericyte	3 studies	23% ± 6%	Explore
extravillous trophoblast	3 studies	61% ± 17%	Explore
placental villous trophoblast	3 studies	57% ± 12%	Explore
club cell	3 studies	24% ± 8%	Explore
capillary endothelial cell	3 studies	21% ± 2%	Explore
mucus secreting cell	3 studies	25% ± 7%	Explore
serous secreting cell	3 studies	18% ± 2%	Explore
mononuclear phagocyte	3 studies	30% ± 12%	Explore
germinal center B cell	3 studies	40% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	21% ± 5%	Explore
granulocyte monocyte progenitor cell	3 studies	28% ± 8%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	51% ± 19%	Explore
enteroendocrine cell	3 studies	27% ± 11%	Explore
transit amplifying cell	3 studies	29% ± 14%	Explore
interneuron	3 studies	40% ± 17%	Explore
luminal cell of prostate epithelium	3 studies	21% ± 7%	Explore
oligodendrocyte precursor cell	3 studies	19% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	11 studies	23% ± 9%	Explore
lung	7 studies	27% ± 9%	Explore
brain	6 studies	27% ± 11%	Explore
eye	5 studies	28% ± 11%	Explore
kidney	4 studies	17% ± 1%	Explore
placenta	4 studies	36% ± 8%	Explore
liver	4 studies	29% ± 13%	Explore
bone marrow	3 studies	20% ± 4%	Explore
lymph node	3 studies	18% ± 3%	Explore
intestine	3 studies	23% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2776.51	1443 / 1445	100%	86.53	183 / 183
stomach	100%	2224.89	359 / 359	99%	81.95	284 / 286
breast	100%	2355.57	459 / 459	99%	85.34	1110 / 1118
bladder	100%	2508.95	21 / 21	99%	82.21	500 / 504
lung	99%	2075.10	573 / 578	100%	79.07	1152 / 1155
prostate	100%	2430.81	245 / 245	99%	78.59	496 / 502
intestine	100%	2141.29	966 / 966	98%	75.78	519 / 527
ovary	98%	1040.24	177 / 180	100%	64.72	430 / 430
uterus	99%	1346.59	169 / 170	98%	52.10	450 / 459
liver	100%	3187.70	226 / 226	97%	39.47	395 / 406
kidney	100%	3156.70	89 / 89	96%	39.29	863 / 901
pancreas	98%	1273.66	321 / 328	96%	37.41	171 / 178
thymus	100%	1692.81	652 / 653	91%	21.80	552 / 605
skin	100%	3604.40	1809 / 1809	89%	43.82	420 / 472
brain	94%	942.28	2488 / 2642	89%	29.82	624 / 705
adrenal gland	100%	2888.62	258 / 258	70%	16.44	162 / 230
adipose	100%	2041.64	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	38.55	29 / 29
muscle	100%	2570.95	803 / 803	0%	0	0 / 0
spleen	100%	2444.87	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	33.69	1 / 1
blood vessel	99%	1449.99	1326 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	46.80	44 / 45
heart	95%	1744.44	816 / 861	0%	0	0 / 0
peripheral blood	85%	2693.60	791 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	56%	22.00	45 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0015908	Biological process	fatty acid transport
GO_1905336	Biological process	negative regulation of aggrephagy
GO_0042997	Biological process	negative regulation of Golgi to plasma membrane protein transport
GO_0006631	Biological process	fatty acid metabolic process
GO_0002084	Biological process	protein depalmitoylation
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005783	Cellular component	endoplasmic reticulum
GO_0031965	Cellular component	nuclear membrane
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0016298	Molecular function	lipase activity
GO_0004622	Molecular function	lysophospholipase activity
GO_0004620	Molecular function	phospholipase activity
GO_0005515	Molecular function	protein binding
GO_0052689	Molecular function	carboxylic ester hydrolase activity
GO_0008474	Molecular function	palmitoyl-(protein) hydrolase activity

IV. Literature review

[source]

Gene name	LYPLA1
Protein name	Acyl-protein thioesterase 1 (APT-1) (hAPT1) (EC 3.1.2.-) (Lysophospholipase 1) (Lysophospholipase I) (LPL-I) (LysoPLA I) (Palmitoyl-protein hydrolase) (EC 3.1.2.22) Acyl-protein thioesterase 1 (EC 3.1.2.22) (Lysophospholipase 1) (Lysophospholipase I) (Palmitoyl-protein hydrolase) Lysophospholipase 1
Synonyms	hCG_1983522 LPL1 APT1
Description	FUNCTION: Acts as an acyl-protein thioesterase . Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS . Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1 . Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes . Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC) . Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity). Has much higher thioesterase activity than lysophospholipase activity . Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA . .
Accessions	ENST00000522007.5 B4DP64 E5RGR0 ENST00000316963.8 [O75608-1] O75608 ENST00000343231.10 [O75608-2] A0A087X1K9 ENST00000521898.5 ENST00000618914.4 E5RFT6 ENST00000618741.1 ENST00000518546.5 ENST00000521352.5 Q6IAQ1 E5RJ48 E5RI35

LYPLA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review