LSM6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006402Biological processmRNA catabolic process
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0008380Biological processRNA splicing
GO_0008033Biological processtRNA processing
GO_0030490Biological processmaturation of SSU-rRNA
GO_0046540Cellular componentU4/U6 x U5 tri-snRNP complex
GO_0005730Cellular componentnucleolus
GO_0120115Cellular componentLsm2-8 complex
GO_0005654Cellular componentnucleoplasm
GO_0071005Cellular componentU2-type precatalytic spliceosome
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005732Cellular componentsno(s)RNA-containing ribonucleoprotein complex
GO_0005688Cellular componentU6 snRNP
GO_0030532Cellular componentsmall nuclear ribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0003723Molecular functionRNA binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLSM6
Protein nameU6 snRNA-associated Sm-like protein LSm6
Synonyms
DescriptionFUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) . The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA . Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway (Probable). .

AccessionsENST00000649747.1
ENST00000504181.1
ENST00000296581.11
ENST00000502781.5
ENST00000515311.5
P62312