LONP2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	23 studies	33% ± 15%	Explore
astrocyte	19 studies	37% ± 18%	Explore
fibroblast	16 studies	26% ± 9%	Explore
ciliated cell	13 studies	25% ± 9%	Explore
B cell	12 studies	20% ± 5%	Explore
macrophage	12 studies	30% ± 13%	Explore
microglial cell	12 studies	36% ± 13%	Explore
smooth muscle cell	11 studies	20% ± 5%	Explore
oligodendrocyte	11 studies	37% ± 13%	Explore
glutamatergic neuron	10 studies	49% ± 23%	Explore
oligodendrocyte precursor cell	10 studies	36% ± 17%	Explore
basal cell	9 studies	31% ± 16%	Explore
GABAergic neuron	9 studies	46% ± 21%	Explore
pericyte	9 studies	24% ± 10%	Explore
epithelial cell	9 studies	37% ± 20%	Explore
adipocyte	9 studies	36% ± 11%	Explore
natural killer cell	8 studies	18% ± 2%	Explore
type I pneumocyte	8 studies	23% ± 7%	Explore
CD4-positive, alpha-beta T cell	8 studies	19% ± 4%	Explore
retinal rod cell	8 studies	22% ± 6%	Explore
T cell	8 studies	20% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	21% ± 4%	Explore
regulatory T cell	7 studies	17% ± 2%	Explore
dendritic cell	7 studies	26% ± 12%	Explore
respiratory goblet cell	6 studies	28% ± 9%	Explore
hepatocyte	6 studies	61% ± 26%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	18% ± 2%	Explore
neuron	6 studies	42% ± 17%	Explore
interneuron	6 studies	49% ± 26%	Explore
connective tissue cell	6 studies	20% ± 4%	Explore
myeloid cell	6 studies	26% ± 2%	Explore
club cell	6 studies	27% ± 9%	Explore
retina horizontal cell	6 studies	28% ± 10%	Explore
retinal cone cell	6 studies	27% ± 8%	Explore
Mueller cell	6 studies	35% ± 18%	Explore
endothelial cell of lymphatic vessel	6 studies	28% ± 8%	Explore
type II pneumocyte	6 studies	26% ± 6%	Explore
gamma-delta T cell	6 studies	19% ± 5%	Explore
plasmacytoid dendritic cell	6 studies	20% ± 3%	Explore
secretory cell	5 studies	24% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	17% ± 1%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	18% ± 2%	Explore
amacrine cell	5 studies	25% ± 9%	Explore
myofibroblast cell	5 studies	23% ± 8%	Explore
cardiac muscle cell	5 studies	30% ± 6%	Explore
mast cell	5 studies	23% ± 5%	Explore
abnormal cell	5 studies	27% ± 15%	Explore
goblet cell	5 studies	32% ± 24%	Explore
classical monocyte	4 studies	23% ± 7%	Explore
mature NK T cell	4 studies	23% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	21% ± 4%	Explore
non-classical monocyte	4 studies	22% ± 6%	Explore
retinal bipolar neuron	4 studies	26% ± 2%	Explore
granule cell	4 studies	30% ± 9%	Explore
mucosal invariant T cell	4 studies	17% ± 1%	Explore
retinal pigment epithelial cell	4 studies	50% ± 17%	Explore
lymphocyte	4 studies	26% ± 6%	Explore
CD8-positive, alpha-beta T cell	4 studies	19% ± 2%	Explore
ionocyte	3 studies	32% ± 5%	Explore
hematopoietic precursor cell	3 studies	23% ± 10%	Explore
plasmablast	3 studies	30% ± 11%	Explore
capillary endothelial cell	3 studies	22% ± 3%	Explore
GABAergic interneuron	3 studies	33% ± 2%	Explore
glial cell	3 studies	25% ± 4%	Explore
retinal ganglion cell	3 studies	30% ± 6%	Explore
plasma cell	3 studies	27% ± 8%	Explore
OFF-bipolar cell	3 studies	24% ± 8%	Explore
ON-bipolar cell	3 studies	24% ± 7%	Explore
glycinergic amacrine cell	3 studies	22% ± 4%	Explore
rod bipolar cell	3 studies	28% ± 7%	Explore
endothelial cell of vascular tree	3 studies	32% ± 16%	Explore
cholangiocyte	3 studies	63% ± 15%	Explore
muscle cell	3 studies	34% ± 19%	Explore
ependymal cell	3 studies	41% ± 21%	Explore
enteroendocrine cell	3 studies	24% ± 7%	Explore
intestinal crypt stem cell	3 studies	18% ± 3%	Explore
alveolar macrophage	3 studies	27% ± 8%	Explore
monocyte	3 studies	29% ± 1%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	19% ± 2%	Explore
T follicular helper cell	3 studies	18% ± 2%	Explore
naive B cell	3 studies	18% ± 3%	Explore
transit amplifying cell	3 studies	37% ± 28%	Explore
memory B cell	3 studies	16% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	41% ± 21%	Explore
eye	10 studies	27% ± 15%	Explore
lung	10 studies	22% ± 6%	Explore
peripheral blood	6 studies	22% ± 6%	Explore
liver	5 studies	35% ± 17%	Explore
heart	4 studies	25% ± 4%	Explore
adipose	4 studies	24% ± 7%	Explore
intestine	3 studies	23% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	6185.87	459 / 459	100%	52.22	1118 / 1118
esophagus	100%	5087.22	1445 / 1445	100%	28.67	183 / 183
prostate	100%	6473.24	245 / 245	100%	51.40	502 / 502
stomach	100%	4102.71	359 / 359	100%	26.83	286 / 286
lung	100%	4372.17	578 / 578	100%	28.93	1154 / 1155
liver	100%	9955.53	226 / 226	100%	33.42	405 / 406
kidney	100%	3632.09	89 / 89	100%	29.72	898 / 901
intestine	100%	5094.15	966 / 966	100%	27.47	525 / 527
bladder	100%	5516.19	21 / 21	100%	26.95	502 / 504
brain	100%	4261.44	2629 / 2642	100%	32.65	705 / 705
pancreas	100%	3818.24	328 / 328	99%	27.71	177 / 178
thymus	100%	8083.02	653 / 653	99%	45.14	601 / 605
skin	100%	5783.98	1809 / 1809	99%	58.33	467 / 472
ovary	100%	6982.98	180 / 180	99%	20.65	425 / 430
uterus	100%	5870.36	170 / 170	98%	22.09	452 / 459
adrenal gland	100%	5586.58	258 / 258	98%	26.60	225 / 230
adipose	100%	4884.27	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4641.85	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	101.97	80 / 80
lymph node	0%	0	0 / 0	100%	18.22	29 / 29
muscle	100%	4227.29	803 / 803	0%	0	0 / 0
spleen	100%	4106.39	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	13.12	1 / 1
heart	97%	4088.96	839 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	18.70	43 / 45
peripheral blood	86%	2801.15	801 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016558	Biological process	protein import into peroxisome matrix
GO_0016485	Biological process	protein processing
GO_0014070	Biological process	response to organic cyclic compound
GO_0031998	Biological process	regulation of fatty acid beta-oxidation
GO_0007031	Biological process	peroxisome organization
GO_0006625	Biological process	protein targeting to peroxisome
GO_0006515	Biological process	protein quality control for misfolded or incompletely synthesized proteins
GO_0016020	Cellular component	membrane
GO_0005634	Cellular component	nucleus
GO_0005777	Cellular component	peroxisome
GO_0005829	Cellular component	cytosol
GO_0005782	Cellular component	peroxisomal matrix
GO_0019899	Molecular function	enzyme binding
GO_0008233	Molecular function	peptidase activity
GO_0004176	Molecular function	ATP-dependent peptidase activity
GO_0002020	Molecular function	protease binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding
GO_0004252	Molecular function	serine-type endopeptidase activity
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	LONP2
Protein name	Lon protease homolog 2, peroxisomal (EC 3.4.21.53) (Lon protease-like protein 2) (Lon protease 2) (Peroxisomal Lon protease) (pLon) LONP2 protein Lon peptidase 2, peroxisomal
Synonyms	LONP
Description	FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. .
Accessions	H3BQ67 Q86WA8 ENST00000285737.9 [Q86WA8-1] ENST00000566755.5 H3BUW8 H3BPF7 ENST00000416006.7 ENST00000570174.1 E7EN44 ENST00000535754.5 [Q86WA8-2] Q9BU35 ENST00000565867.2

LONP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review