LNPEP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	31 studies	29% ± 8%	Explore
B cell	25 studies	23% ± 6%	Explore
T cell	20 studies	23% ± 9%	Explore
CD4-positive, alpha-beta T cell	20 studies	22% ± 6%	Explore
CD8-positive, alpha-beta T cell	20 studies	26% ± 7%	Explore
naive B cell	18 studies	23% ± 6%	Explore
regulatory T cell	17 studies	23% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	32% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	29% ± 6%	Explore
mature NK T cell	14 studies	24% ± 6%	Explore
gamma-delta T cell	14 studies	27% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	21% ± 4%	Explore
endothelial cell	13 studies	26% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	23% ± 7%	Explore
non-classical monocyte	12 studies	27% ± 12%	Explore
astrocyte	12 studies	31% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	26% ± 5%	Explore
glutamatergic neuron	11 studies	34% ± 22%	Explore
mucosal invariant T cell	11 studies	22% ± 4%	Explore
oligodendrocyte	11 studies	27% ± 10%	Explore
memory B cell	10 studies	23% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	23% ± 4%	Explore
adipocyte	10 studies	40% ± 9%	Explore
microglial cell	9 studies	28% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	23% ± 7%	Explore
GABAergic neuron	8 studies	35% ± 20%	Explore
monocyte	8 studies	24% ± 5%	Explore
plasmacytoid dendritic cell	8 studies	22% ± 8%	Explore
macrophage	7 studies	29% ± 8%	Explore
epithelial cell	7 studies	31% ± 13%	Explore
fibroblast	6 studies	19% ± 4%	Explore
smooth muscle cell	6 studies	18% ± 2%	Explore
basal cell	6 studies	27% ± 12%	Explore
neuron	6 studies	34% ± 14%	Explore
dendritic cell	6 studies	25% ± 10%	Explore
T follicular helper cell	6 studies	21% ± 3%	Explore
oligodendrocyte precursor cell	6 studies	26% ± 11%	Explore
endothelial cell of lymphatic vessel	5 studies	24% ± 7%	Explore
classical monocyte	5 studies	23% ± 9%	Explore
lymphocyte	5 studies	31% ± 13%	Explore
precursor B cell	5 studies	26% ± 5%	Explore
cardiac muscle cell	5 studies	27% ± 5%	Explore
innate lymphoid cell	5 studies	23% ± 4%	Explore
goblet cell	5 studies	32% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	22% ± 3%	Explore
leukocyte	4 studies	32% ± 11%	Explore
exhausted T cell	4 studies	24% ± 7%	Explore
retinal ganglion cell	4 studies	39% ± 15%	Explore
pro-B cell	4 studies	22% ± 3%	Explore
myeloid cell	4 studies	22% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	21% ± 5%	Explore
pericyte	4 studies	22% ± 5%	Explore
type I pneumocyte	4 studies	20% ± 5%	Explore
interneuron	4 studies	45% ± 25%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	23% ± 3%	Explore
hematopoietic precursor cell	3 studies	31% ± 10%	Explore
GABAergic interneuron	3 studies	19% ± 1%	Explore
plasma cell	3 studies	24% ± 5%	Explore
retinal cone cell	3 studies	25% ± 5%	Explore
ciliated cell	3 studies	26% ± 3%	Explore
rod bipolar cell	3 studies	27% ± 7%	Explore
germinal center B cell	3 studies	26% ± 6%	Explore
connective tissue cell	3 studies	17% ± 2%	Explore
alveolar macrophage	3 studies	31% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	28% ± 8%	Explore
T-helper 17 cell	3 studies	19% ± 3%	Explore
immature B cell	3 studies	19% ± 4%	Explore
mast cell	3 studies	24% ± 3%	Explore
double negative thymocyte	3 studies	29% ± 5%	Explore
abnormal cell	3 studies	28% ± 6%	Explore
kidney loop of Henle epithelial cell	3 studies	22% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	30% ± 17%	Explore
peripheral blood	12 studies	23% ± 8%	Explore
lung	5 studies	20% ± 4%	Explore
eye	5 studies	22% ± 9%	Explore
heart	4 studies	19% ± 3%	Explore
kidney	4 studies	20% ± 2%	Explore
adipose	4 studies	30% ± 12%	Explore
bone marrow	3 studies	21% ± 1%	Explore
liver	3 studies	24% ± 8%	Explore
lymph node	3 studies	21% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5331.01	1445 / 1445	100%	20.27	183 / 183
prostate	100%	4327.19	245 / 245	100%	19.88	502 / 502
lung	100%	4017.99	577 / 578	100%	14.09	1152 / 1155
thymus	100%	3852.76	653 / 653	99%	18.74	601 / 605
kidney	100%	2999.45	89 / 89	99%	22.77	895 / 901
breast	100%	4485.11	458 / 459	99%	23.40	1112 / 1118
brain	99%	3404.69	2623 / 2642	100%	12.45	704 / 705
uterus	100%	4271.71	170 / 170	99%	14.70	455 / 459
bladder	100%	4326.52	21 / 21	99%	13.64	498 / 504
stomach	100%	3989.17	359 / 359	98%	14.32	281 / 286
ovary	100%	4083.74	180 / 180	98%	9.06	420 / 430
intestine	100%	4930.64	966 / 966	97%	12.45	512 / 527
pancreas	98%	1775.28	322 / 328	98%	15.55	175 / 178
adrenal gland	99%	2323.04	256 / 258	96%	14.57	221 / 230
skin	100%	5411.27	1809 / 1809	93%	12.54	441 / 472
liver	96%	1369.56	217 / 226	69%	5.57	279 / 406
blood vessel	100%	6201.73	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	29.31	29 / 29
muscle	100%	4079.43	803 / 803	0%	0	0 / 0
spleen	100%	5182.96	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	19.17	45 / 45
adipose	100%	5455.20	1203 / 1204	0%	0	0 / 0
heart	98%	3919.04	847 / 861	0%	0	0 / 0
peripheral blood	89%	4669.14	829 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	61%	4.15	49 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0000209	Biological process	protein polyubiquitination
GO_0008217	Biological process	regulation of blood pressure
GO_0007565	Biological process	female pregnancy
GO_0007267	Biological process	cell-cell signaling
GO_0006508	Biological process	proteolysis
GO_0002480	Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO_0030163	Biological process	protein catabolic process
GO_0043171	Biological process	peptide catabolic process
GO_0120163	Biological process	negative regulation of cold-induced thermogenesis
GO_0005615	Cellular component	extracellular space
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0031905	Cellular component	early endosome lumen
GO_0030659	Cellular component	cytoplasmic vesicle membrane
GO_0005765	Cellular component	lysosomal membrane
GO_0070006	Molecular function	metalloaminopeptidase activity
GO_0008237	Molecular function	metallopeptidase activity
GO_0042277	Molecular function	peptide binding
GO_0008270	Molecular function	zinc ion binding
GO_0004177	Molecular function	aminopeptidase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LNPEP
Protein name	Leucyl-cystinyl aminopeptidase (Cystinyl aminopeptidase) (EC 3.4.11.3) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Oxytocinase) (OTase) (Placental leucine aminopeptidase) (P-LAP) [Cleaved into: Leucyl-cystinyl aminopeptidase, pregnancy serum form]
Synonyms	OTASE
Description	FUNCTION: Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. .
Accessions	Q9UIQ6 ENST00000395770.3 [Q9UIQ6-2] ENST00000231368.10 [Q9UIQ6-1]

LNPEP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review