LMBRD1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	24 studies	30% ± 9%	Explore
endothelial cell	19 studies	27% ± 10%	Explore
memory B cell	18 studies	26% ± 8%	Explore
naive B cell	16 studies	29% ± 9%	Explore
ciliated cell	14 studies	27% ± 10%	Explore
astrocyte	14 studies	33% ± 16%	Explore
oligodendrocyte	14 studies	33% ± 13%	Explore
fibroblast	14 studies	22% ± 8%	Explore
macrophage	13 studies	26% ± 9%	Explore
oligodendrocyte precursor cell	13 studies	33% ± 16%	Explore
regulatory T cell	13 studies	22% ± 3%	Explore
natural killer cell	12 studies	18% ± 3%	Explore
glutamatergic neuron	11 studies	45% ± 25%	Explore
microglial cell	11 studies	26% ± 10%	Explore
type I pneumocyte	9 studies	22% ± 5%	Explore
non-classical monocyte	9 studies	24% ± 9%	Explore
GABAergic neuron	9 studies	48% ± 23%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	19% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	21% ± 3%	Explore
plasmacytoid dendritic cell	9 studies	24% ± 5%	Explore
CD4-positive, alpha-beta T cell	8 studies	19% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	18% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	18% ± 2%	Explore
T cell	8 studies	20% ± 3%	Explore
gamma-delta T cell	8 studies	20% ± 4%	Explore
pericyte	7 studies	20% ± 4%	Explore
CD8-positive, alpha-beta T cell	7 studies	19% ± 2%	Explore
epithelial cell	7 studies	38% ± 16%	Explore
interneuron	6 studies	49% ± 26%	Explore
myeloid cell	6 studies	20% ± 4%	Explore
club cell	6 studies	21% ± 7%	Explore
retinal cone cell	6 studies	33% ± 12%	Explore
retinal rod cell	6 studies	25% ± 6%	Explore
adipocyte	6 studies	23% ± 4%	Explore
dendritic cell	6 studies	27% ± 13%	Explore
plasma cell	5 studies	27% ± 8%	Explore
conventional dendritic cell	5 studies	23% ± 10%	Explore
retinal bipolar neuron	5 studies	28% ± 10%	Explore
amacrine cell	5 studies	34% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	19% ± 2%	Explore
type II pneumocyte	5 studies	18% ± 4%	Explore
monocyte	5 studies	26% ± 5%	Explore
mucosal invariant T cell	5 studies	18% ± 1%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	19% ± 3%	Explore
classical monocyte	4 studies	21% ± 3%	Explore
capillary endothelial cell	4 studies	16% ± 1%	Explore
neuron	4 studies	41% ± 10%	Explore
granule cell	4 studies	33% ± 10%	Explore
kidney loop of Henle epithelial cell	4 studies	32% ± 13%	Explore
precursor B cell	4 studies	27% ± 8%	Explore
immature B cell	4 studies	32% ± 6%	Explore
retina horizontal cell	4 studies	23% ± 6%	Explore
cardiac muscle cell	4 studies	23% ± 1%	Explore
Mueller cell	4 studies	24% ± 7%	Explore
abnormal cell	4 studies	29% ± 9%	Explore
alveolar macrophage	4 studies	27% ± 7%	Explore
endothelial cell of lymphatic vessel	4 studies	20% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	23% ± 4%	Explore
basal cell	4 studies	33% ± 13%	Explore
mature NK T cell	4 studies	18% ± 2%	Explore
squamous epithelial cell	3 studies	32% ± 22%	Explore
plasmablast	3 studies	37% ± 20%	Explore
glomerular endothelial cell	3 studies	20% ± 2%	Explore
GABAergic interneuron	3 studies	31% ± 6%	Explore
glial cell	3 studies	19% ± 2%	Explore
retinal ganglion cell	3 studies	29% ± 6%	Explore
mononuclear phagocyte	3 studies	19% ± 3%	Explore
lymphocyte	3 studies	27% ± 10%	Explore
GABAergic amacrine cell	3 studies	37% ± 14%	Explore
ON-bipolar cell	3 studies	34% ± 14%	Explore
glycinergic amacrine cell	3 studies	26% ± 8%	Explore
rod bipolar cell	3 studies	30% ± 8%	Explore
myofibroblast cell	3 studies	19% ± 1%	Explore
hepatocyte	3 studies	41% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	21% ± 3%	Explore
ependymal cell	3 studies	36% ± 13%	Explore
respiratory goblet cell	3 studies	21% ± 8%	Explore
T follicular helper cell	3 studies	20% ± 3%	Explore
smooth muscle cell	3 studies	17% ± 1%	Explore
mast cell	3 studies	21% ± 3%	Explore
double negative thymocyte	3 studies	22% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	36% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	36% ± 21%	Explore
peripheral blood	11 studies	19% ± 3%	Explore
lung	7 studies	19% ± 4%	Explore
eye	7 studies	29% ± 8%	Explore
heart	4 studies	17% ± 1%	Explore
kidney	4 studies	22% ± 4%	Explore
lymph node	4 studies	17% ± 1%	Explore
adipose	3 studies	21% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	3266.56	578 / 578	100%	16.02	1154 / 1155
brain	100%	4233.12	2642 / 2642	100%	27.77	704 / 705
ovary	100%	3562.08	180 / 180	100%	15.93	428 / 430
pancreas	100%	2435.36	328 / 328	99%	18.76	177 / 178
thymus	100%	4249.91	653 / 653	99%	43.13	601 / 605
prostate	100%	2208.87	245 / 245	99%	17.76	498 / 502
breast	100%	3714.17	459 / 459	99%	18.91	1108 / 1118
esophagus	100%	2798.32	1445 / 1445	99%	13.31	181 / 183
adrenal gland	100%	5440.68	258 / 258	98%	31.32	226 / 230
kidney	100%	3591.40	89 / 89	98%	29.93	885 / 901
liver	100%	2485.99	226 / 226	98%	15.57	398 / 406
bladder	100%	3342.24	21 / 21	98%	15.32	493 / 504
stomach	100%	2592.55	359 / 359	98%	15.74	279 / 286
intestine	100%	2942.67	966 / 966	98%	15.20	514 / 527
uterus	100%	2855.84	170 / 170	97%	11.95	445 / 459
skin	100%	2765.06	1808 / 1809	91%	11.64	430 / 472
blood vessel	100%	3396.91	1335 / 1335	0%	0	0 / 0
spleen	100%	2532.25	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	4.15	1 / 1
adipose	100%	3623.09	1203 / 1204	0%	0	0 / 0
muscle	100%	1882.32	801 / 803	0%	0	0 / 0
heart	98%	2065.57	845 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	10.07	28 / 29
tonsil	0%	0	0 / 0	96%	11.14	43 / 45
peripheral blood	91%	2350.60	850 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	81%	9.75	65 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0072583	Biological process	clathrin-dependent endocytosis
GO_0061462	Biological process	protein localization to lysosome
GO_0038016	Biological process	insulin receptor internalization
GO_0007369	Biological process	gastrulation
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0030136	Cellular component	clathrin-coated vesicle
GO_0005886	Cellular component	plasma membrane
GO_0005765	Cellular component	lysosomal membrane
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0045334	Cellular component	clathrin-coated endocytic vesicle
GO_0032050	Molecular function	clathrin heavy chain binding
GO_0031419	Molecular function	cobalamin binding
GO_0005158	Molecular function	insulin receptor binding
GO_0035612	Molecular function	AP-2 adaptor complex binding
GO_0005515	Molecular function	protein binding
GO_0140318	Molecular function	protein transporter activity

IV. Literature review

[source]

Gene name	LMBRD1
Protein name	Lysosomal cobalamin transport escort protein LMBD1 (LMBD1) (HDAg-L-interacting protein NESI) (LMBR1 domain-containing protein 1) (Nuclear export signal-interacting protein) Lysosomal cobalamin transport escort protein LMBD1 (LMBR1 domain-containing protein 1) LMBR1 domain containing 1
Synonyms	CD001 MSTP044 C6orf209 BM-021 NESI
Description	FUNCTION: Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors . Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome . Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane . Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity). .; FUNCTION: [Isoform 3]: (Microbial infection) May play a role in the assembly of hepatitis delta virus (HDV). .
Accessions	A0A3B3ITR7 A0A3B3IU68 ENST00000648303.1 A0A3B3IRL1 ENST00000649054.1 ENST00000649918.1 [Q9NUN5-3] A0A494C126 ENST00000649970.1 ENST00000650473.1 ENST00000648635.1 A0A3F2YP66 ENST00000649028.1 [Q9NUN5-3] A0A3B3IU99 A0A3B3IS10 ENST00000649934.3 [Q9NUN5-1] ENST00000649795.1 ENST00000650124.1 A0A3B3IRS7 ENST00000472827.2 A0A3B3ITM4 ENST00000649679.1 [Q9NUN5-3] ENST00000370570.6 [Q9NUN5-3] ENST00000648743.1 [Q9NUN5-3] ENST00000649166.1 ENST00000647964.1 [Q9NUN5-3] A0A3B3IRN0 ENST00000649673.1 A0A3B3ITP2 ENST00000647650.1 ENST00000647669.1 A0A3B3IS99 ENST00000649057.1 ENST00000651675.1 A0A3B3IU91 ENST00000649011.1 ENST00000648394.1 [Q9NUN5-3] ENST00000648168.1 [Q9NUN5-3] ENST00000650035.1 [Q9NUN5-3] ENST00000650107.1 [Q9NUN5-3] A0A3B3IT65 ENST00000649958.1 A0A3B3IT31 Q9NUN5

LMBRD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review