KLHL24 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	18 studies	28% ± 12%	Explore
B cell	15 studies	24% ± 8%	Explore
astrocyte	15 studies	33% ± 17%	Explore
oligodendrocyte	15 studies	38% ± 15%	Explore
fibroblast	13 studies	22% ± 9%	Explore
macrophage	12 studies	27% ± 12%	Explore
natural killer cell	11 studies	20% ± 5%	Explore
GABAergic neuron	10 studies	41% ± 23%	Explore
oligodendrocyte precursor cell	10 studies	35% ± 16%	Explore
type I pneumocyte	9 studies	32% ± 8%	Explore
glutamatergic neuron	9 studies	49% ± 25%	Explore
microglial cell	9 studies	26% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	19% ± 3%	Explore
type II pneumocyte	7 studies	33% ± 8%	Explore
naive B cell	7 studies	23% ± 4%	Explore
club cell	7 studies	35% ± 15%	Explore
adipocyte	7 studies	30% ± 9%	Explore
T cell	6 studies	21% ± 5%	Explore
interneuron	6 studies	46% ± 23%	Explore
myeloid cell	6 studies	20% ± 4%	Explore
epithelial cell	6 studies	37% ± 10%	Explore
retina horizontal cell	6 studies	25% ± 8%	Explore
pericyte	6 studies	21% ± 5%	Explore
smooth muscle cell	6 studies	18% ± 3%	Explore
neuron	5 studies	39% ± 15%	Explore
precursor B cell	5 studies	32% ± 6%	Explore
basal cell	5 studies	25% ± 7%	Explore
amacrine cell	5 studies	20% ± 4%	Explore
cardiac muscle cell	5 studies	54% ± 11%	Explore
ciliated cell	5 studies	26% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	17% ± 1%	Explore
memory B cell	5 studies	20% ± 3%	Explore
regulatory T cell	5 studies	18% ± 3%	Explore
leukocyte	4 studies	20% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	22% ± 3%	Explore
CD4-positive, alpha-beta T cell	4 studies	24% ± 7%	Explore
granule cell	4 studies	24% ± 3%	Explore
retinal ganglion cell	4 studies	22% ± 8%	Explore
gamma-delta T cell	4 studies	23% ± 7%	Explore
monocyte	4 studies	21% ± 2%	Explore
squamous epithelial cell	3 studies	36% ± 22%	Explore
classical monocyte	3 studies	24% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	22% ± 6%	Explore
mature NK T cell	3 studies	16% ± 0%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	22% ± 4%	Explore
GABAergic interneuron	3 studies	28% ± 2%	Explore
progenitor cell	3 studies	24% ± 3%	Explore
pro-B cell	3 studies	30% ± 5%	Explore
plasma cell	3 studies	27% ± 8%	Explore
mast cell	3 studies	26% ± 7%	Explore
retinal pigment epithelial cell	3 studies	32% ± 15%	Explore
lymphocyte	3 studies	26% ± 6%	Explore
retinal cone cell	3 studies	18% ± 2%	Explore
GABAergic amacrine cell	3 studies	27% ± 3%	Explore
glycinergic amacrine cell	3 studies	30% ± 2%	Explore
retinal rod cell	3 studies	18% ± 2%	Explore
CD8-positive, alpha-beta T cell	3 studies	23% ± 6%	Explore
dendritic cell	3 studies	30% ± 12%	Explore
ependymal cell	3 studies	36% ± 20%	Explore
enteroendocrine cell	3 studies	20% ± 4%	Explore
alveolar macrophage	3 studies	24% ± 5%	Explore
endothelial cell of lymphatic vessel	3 studies	25% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	23% ± 5%	Explore
goblet cell	3 studies	39% ± 24%	Explore
abnormal cell	3 studies	19% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	40% ± 20%	Explore
lung	8 studies	22% ± 6%	Explore
peripheral blood	4 studies	29% ± 10%	Explore
heart	4 studies	33% ± 7%	Explore
eye	4 studies	27% ± 12%	Explore
intestine	3 studies	17% ± 1%	Explore
adipose	3 studies	21% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	4579.62	180 / 180	100%	37.85	430 / 430
lung	100%	5102.93	578 / 578	100%	37.56	1154 / 1155
brain	100%	2751.42	2632 / 2642	100%	27.58	703 / 705
kidney	100%	2278.09	89 / 89	99%	29.12	894 / 901
thymus	100%	4988.85	653 / 653	99%	25.92	600 / 605
prostate	100%	3530.22	245 / 245	99%	23.68	495 / 502
breast	100%	4246.36	459 / 459	99%	26.40	1102 / 1118
esophagus	99%	3101.91	1435 / 1445	99%	37.27	181 / 183
stomach	100%	2736.44	358 / 359	98%	22.18	280 / 286
intestine	100%	4061.36	966 / 966	97%	17.85	509 / 527
pancreas	98%	1845.08	322 / 328	98%	21.32	175 / 178
bladder	100%	4134.62	21 / 21	96%	21.89	486 / 504
uterus	99%	3822.48	169 / 170	96%	23.49	439 / 459
adrenal gland	99%	2969.65	255 / 258	95%	17.15	219 / 230
skin	96%	2610.31	1740 / 1809	94%	22.47	444 / 472
liver	99%	2065.04	223 / 226	90%	12.98	366 / 406
muscle	100%	7416.58	803 / 803	0%	0	0 / 0
spleen	100%	3030.21	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	9.15	1 / 1
blood vessel	100%	3365.00	1332 / 1335	0%	0	0 / 0
adipose	100%	4399.36	1200 / 1204	0%	0	0 / 0
heart	98%	5105.36	846 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	31.76	43 / 45
lymph node	0%	0	0 / 0	93%	17.26	27 / 29
peripheral blood	91%	1836.45	841 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	71%	11.27	57 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045109	Biological process	intermediate filament organization
GO_0051865	Biological process	protein autoubiquitination
GO_0016567	Biological process	protein ubiquitination
GO_0043204	Cellular component	perikaryon
GO_0030057	Cellular component	desmosome
GO_0030424	Cellular component	axon
GO_0005912	Cellular component	adherens junction
GO_0031463	Cellular component	Cul3-RING ubiquitin ligase complex
GO_0005737	Cellular component	cytoplasm
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	KLHL24
Protein name	Kelch like family member 24 Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1)
Synonyms	DRE1
Description	FUNCTION: Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity . As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation . Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). Has a crucial role in cardiac development and function . .
Accessions	C9J3M5 ENST00000468001.1 ENST00000454652.6 [Q6TFL4-1] C9JMQ9 C9J2N4 C9J0A6 C9JCK3 ENST00000437402.5 C9JN72 Q6TFL4 ENST00000242810.11 [Q6TFL4-1] ENST00000482138.1 ENST00000473045.5 ENST00000427201.2 ENST00000454495.6 C9JQ67 C9JXR5 ENST00000476808.1 [Q6TFL4-2] ENST00000468101.5 ENST00000493074.1

KLHL24 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review