KDM2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032922Biological processcircadian regulation of gene expression
GO_0006482Biological processprotein demethylation
GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0010944Biological processnegative regulation of transcription by competitive promoter binding
GO_0006338Biological processchromatin remodeling
GO_0042752Biological processregulation of circadian rhythm
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0032452Molecular functionhistone demethylase activity
GO_0045322Molecular functionunmethylated CpG binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0140680Molecular functionhistone H3K36me/H3K36me2 demethylase activity
GO_0003712Molecular functiontranscription coregulator activity
GO_0051864Molecular functionhistone H3K36 demethylase activity

IV. Literature review

[source]
Gene nameKDM2A
Protein nameF-box and leucine-rich repeat protein 11, isoform CRA_a (Lysine-specific demethylase 2A)
Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A)
Alternative protein KDM2A
Lysine demethylase 2A (N-terminus deleted lysine-specific demethylase 2A)
SynonymsKIAA1004
FBL7
JHDM1A
CXXC8
FBL11
hCG_21062
FBXL11
DescriptionFUNCTION: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner . .

AccessionsENST00000530342.2 [Q9Y2K7-5]
I3VM53
ENST00000308783.9
L0R5B6
ENST00000398645.6 [Q9Y2K7-3]
Q9Y2K7
ENST00000529006.7 [Q9Y2K7-1]
I3VM54