FYB1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	42 studies	45% ± 17%	Explore
natural killer cell	42 studies	44% ± 16%	Explore
CD8-positive, alpha-beta T cell	39 studies	54% ± 19%	Explore
T cell	37 studies	49% ± 17%	Explore
CD4-positive, alpha-beta T cell	32 studies	63% ± 18%	Explore
regulatory T cell	27 studies	64% ± 15%	Explore
classical monocyte	26 studies	63% ± 17%	Explore
conventional dendritic cell	26 studies	40% ± 14%	Explore
monocyte	25 studies	52% ± 17%	Explore
non-classical monocyte	24 studies	66% ± 14%	Explore
mature NK T cell	19 studies	49% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	19 studies	67% ± 17%	Explore
dendritic cell	17 studies	40% ± 14%	Explore
plasmacytoid dendritic cell	17 studies	37% ± 13%	Explore
myeloid cell	17 studies	49% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	53% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	68% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	53% ± 13%	Explore
gamma-delta T cell	15 studies	50% ± 15%	Explore
microglial cell	13 studies	63% ± 17%	Explore
mucosal invariant T cell	13 studies	42% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	61% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	66% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	61% ± 18%	Explore
neutrophil	11 studies	46% ± 9%	Explore
platelet	10 studies	51% ± 16%	Explore
leukocyte	10 studies	49% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	50% ± 21%	Explore
T follicular helper cell	8 studies	71% ± 13%	Explore
CD4-positive helper T cell	6 studies	53% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	66% ± 21%	Explore
mononuclear phagocyte	6 studies	51% ± 12%	Explore
megakaryocyte	6 studies	68% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	70% ± 14%	Explore
alveolar macrophage	5 studies	30% ± 10%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	63% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	47% ± 15%	Explore
exhausted T cell	5 studies	72% ± 11%	Explore
lymphocyte	5 studies	56% ± 13%	Explore
double negative thymocyte	5 studies	73% ± 12%	Explore
intermediate monocyte	5 studies	68% ± 21%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	46% ± 20%	Explore
innate lymphoid cell	4 studies	38% ± 19%	Explore
hematopoietic precursor cell	4 studies	30% ± 11%	Explore
brush cell	4 studies	84% ± 12%	Explore
thymocyte	3 studies	28% ± 8%	Explore
tissue-resident macrophage	3 studies	51% ± 11%	Explore
mast cell	3 studies	39% ± 7%	Explore
T-helper 17 cell	3 studies	50% ± 14%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	82% ± 4%	Explore
double-positive, alpha-beta thymocyte	3 studies	81% ± 2%	Explore
T-helper 1 cell	3 studies	64% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	51% ± 16%	Explore
lung	7 studies	27% ± 7%	Explore
lymph node	4 studies	36% ± 19%	Explore
brain	4 studies	29% ± 10%	Explore
bone marrow	3 studies	43% ± 17%	Explore
liver	3 studies	37% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	2480.78	578 / 578	88%	13.99	1016 / 1155
breast	91%	522.29	419 / 459	88%	11.94	980 / 1118
kidney	97%	712.84	86 / 89	80%	13.76	722 / 901
esophagus	56%	306.80	803 / 1445	87%	13.58	159 / 183
stomach	69%	298.21	247 / 359	72%	10.04	207 / 286
brain	51%	403.08	1351 / 2642	87%	11.58	611 / 705
intestine	82%	917.52	792 / 966	56%	5.75	293 / 527
thymus	81%	522.41	527 / 653	54%	11.96	327 / 605
prostate	86%	508.05	210 / 245	43%	3.01	215 / 502
uterus	65%	254.63	110 / 170	62%	7.07	285 / 459
bladder	71%	555.52	15 / 21	52%	7.25	260 / 504
skin	33%	113.73	591 / 1809	77%	15.32	365 / 472
liver	70%	295.62	159 / 226	31%	2.40	127 / 406
spleen	100%	6579.54	241 / 241	0%	0	0 / 0
adipose	99%	989.63	1186 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	38.03	28 / 29
pancreas	16%	70.22	54 / 328	78%	9.39	139 / 178
adrenal gland	78%	365.42	202 / 258	16%	0.88	37 / 230
ovary	28%	104.47	50 / 180	64%	4.92	277 / 430
peripheral blood	87%	11057.31	810 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	84%	15.49	38 / 45
blood vessel	69%	458.49	915 / 1335	0%	0	0 / 0
heart	36%	146.67	307 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	19%	1.15	15 / 80
muscle	5%	13.38	38 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006955	Biological process	immune response
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0072659	Biological process	protein localization to plasma membrane
GO_0050852	Biological process	T cell receptor signaling pathway
GO_0008150	Biological process	biological_process
GO_0015629	Cellular component	actin cytoskeleton
GO_0032991	Cellular component	protein-containing complex
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0070161	Cellular component	anchoring junction
GO_0005634	Cellular component	nucleus
GO_0044877	Molecular function	protein-containing complex binding
GO_0008289	Molecular function	lipid binding
GO_0005102	Molecular function	signaling receptor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	FYB1
Protein name	FYB protein FYN binding protein 1 FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein)
Synonyms	FYB SLAP130
Description	FUNCTION: Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton . Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 . May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). .
Accessions	Q05DE9 ENST00000515010.5 [O15117-1] D6RER7 ENST00000506557.5 O15117 ENST00000509072.5 ENST00000512982.4 [O15117-2] A0A2R8YEE1 D6RC38 ENST00000351578.12 [O15117-1] ENST00000510188.1 ENST00000646045.2 [O15117-3] ENST00000512138.1 D6RAE8 D6RFJ5 ENST00000646444.1

FYB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review