FKBP5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	32 studies	46% ± 21%	Explore
endothelial cell	31 studies	43% ± 20%	Explore
CD4-positive, alpha-beta T cell	27 studies	34% ± 18%	Explore
T cell	26 studies	32% ± 15%	Explore
natural killer cell	23 studies	27% ± 10%	Explore
fibroblast	23 studies	41% ± 19%	Explore
pericyte	22 studies	38% ± 16%	Explore
smooth muscle cell	21 studies	35% ± 15%	Explore
classical monocyte	21 studies	35% ± 12%	Explore
CD8-positive, alpha-beta T cell	20 studies	30% ± 12%	Explore
dendritic cell	18 studies	49% ± 16%	Explore
non-classical monocyte	16 studies	34% ± 12%	Explore
monocyte	15 studies	36% ± 20%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	33% ± 18%	Explore
conventional dendritic cell	15 studies	38% ± 17%	Explore
microglial cell	15 studies	54% ± 22%	Explore
regulatory T cell	15 studies	31% ± 13%	Explore
mast cell	14 studies	41% ± 19%	Explore
B cell	12 studies	28% ± 9%	Explore
myeloid cell	12 studies	45% ± 24%	Explore
astrocyte	11 studies	42% ± 17%	Explore
adipocyte	10 studies	60% ± 23%	Explore
gamma-delta T cell	10 studies	27% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	28% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	23% ± 6%	Explore
capillary endothelial cell	9 studies	45% ± 14%	Explore
mature NK T cell	9 studies	35% ± 13%	Explore
oligodendrocyte	9 studies	40% ± 17%	Explore
plasmacytoid dendritic cell	9 studies	29% ± 11%	Explore
alveolar macrophage	8 studies	46% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	27% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	37% ± 22%	Explore
oligodendrocyte precursor cell	8 studies	44% ± 17%	Explore
mucosal invariant T cell	8 studies	38% ± 17%	Explore
endothelial cell of artery	8 studies	36% ± 16%	Explore
innate lymphoid cell	8 studies	47% ± 19%	Explore
mesothelial cell	8 studies	41% ± 22%	Explore
T follicular helper cell	8 studies	38% ± 14%	Explore
kidney loop of Henle epithelial cell	7 studies	33% ± 23%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	28% ± 14%	Explore
epithelial cell	7 studies	33% ± 15%	Explore
vein endothelial cell	7 studies	40% ± 17%	Explore
endothelial cell of vascular tree	7 studies	41% ± 15%	Explore
endothelial cell of lymphatic vessel	6 studies	26% ± 12%	Explore
plasma cell	6 studies	38% ± 13%	Explore
myofibroblast cell	6 studies	39% ± 18%	Explore
leukocyte	6 studies	48% ± 23%	Explore
neutrophil	5 studies	41% ± 26%	Explore
connective tissue cell	5 studies	33% ± 8%	Explore
mononuclear phagocyte	5 studies	59% ± 24%	Explore
hepatocyte	5 studies	66% ± 27%	Explore
GABAergic neuron	5 studies	22% ± 3%	Explore
hematopoietic precursor cell	5 studies	23% ± 8%	Explore
abnormal cell	5 studies	28% ± 8%	Explore
lymphocyte	5 studies	44% ± 26%	Explore
adventitial cell	5 studies	35% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	39% ± 16%	Explore
cardiac muscle cell	5 studies	51% ± 16%	Explore
glutamatergic neuron	5 studies	24% ± 5%	Explore
cholangiocyte	4 studies	65% ± 18%	Explore
ciliated cell	4 studies	26% ± 13%	Explore
basal cell	4 studies	41% ± 20%	Explore
intermediate monocyte	4 studies	55% ± 22%	Explore
CD4-positive helper T cell	4 studies	35% ± 16%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	32% ± 6%	Explore
muscle cell	4 studies	60% ± 26%	Explore
type II pneumocyte	4 studies	23% ± 3%	Explore
epithelial cell of proximal tubule	4 studies	48% ± 24%	Explore
endothelial cell of sinusoid	3 studies	36% ± 18%	Explore
hepatic stellate cell	3 studies	63% ± 9%	Explore
glomerular endothelial cell	3 studies	66% ± 14%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	33% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	31% ± 11%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	27% ± 11%	Explore
group 3 innate lymphoid cell	3 studies	30% ± 19%	Explore
Schwann cell	3 studies	47% ± 13%	Explore
melanocyte	3 studies	62% ± 29%	Explore
transit amplifying cell	3 studies	42% ± 30%	Explore
erythroblast	3 studies	24% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	20% ± 3%	Explore
double negative thymocyte	3 studies	18% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	39% ± 18%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	39% ± 23%	Explore
mural cell	3 studies	35% ± 17%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	13 studies	30% ± 10%	Explore
brain	12 studies	33% ± 12%	Explore
peripheral blood	11 studies	28% ± 11%	Explore
liver	8 studies	35% ± 15%	Explore
kidney	7 studies	35% ± 9%	Explore
intestine	5 studies	21% ± 5%	Explore
heart	5 studies	47% ± 17%	Explore
adipose	5 studies	44% ± 21%	Explore
eye	4 studies	31% ± 20%	Explore
lymph node	4 studies	42% ± 11%	Explore
bone marrow	3 studies	21% ± 4%	Explore
uterus	3 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	84%	16704.69	205 / 245	100%	100.91	501 / 502
adrenal gland	85%	10675.28	220 / 258	97%	49.65	222 / 230
esophagus	82%	33793.26	1190 / 1445	88%	32.49	161 / 183
thymus	77%	20120.93	503 / 653	93%	35.43	562 / 605
breast	81%	28134.82	374 / 459	88%	36.20	984 / 1118
uterus	75%	15944.02	128 / 170	88%	25.67	406 / 459
lung	76%	17849.72	439 / 578	87%	28.77	1007 / 1155
skin	88%	22197.04	1599 / 1809	72%	21.65	342 / 472
pancreas	68%	9295.42	223 / 328	91%	45.51	162 / 178
intestine	81%	20553.08	786 / 966	77%	16.69	408 / 527
stomach	79%	19678.08	283 / 359	78%	15.69	223 / 286
ovary	82%	19486.12	147 / 180	62%	12.84	265 / 430
liver	50%	6407.35	114 / 226	91%	38.35	368 / 406
bladder	76%	19819.57	16 / 21	63%	15.47	318 / 504
kidney	55%	9186.78	49 / 89	80%	42.14	717 / 901
lymph node	0%	0	0 / 0	100%	54.35	29 / 29
tonsil	0%	0	0 / 0	96%	41.59	43 / 45
muscle	93%	96119.98	743 / 803	0%	0	0 / 0
brain	13%	1092.22	336 / 2642	80%	31.57	561 / 705
adipose	86%	35884.04	1038 / 1204	0%	0	0 / 0
spleen	85%	19638.61	204 / 241	0%	0	0 / 0
blood vessel	81%	25522.27	1085 / 1335	0%	0	0 / 0
peripheral blood	73%	25745.37	682 / 929	0%	0	0 / 0
heart	60%	10590.33	516 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	35%	5.24	28 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006457	Biological process	protein folding
GO_0061077	Biological process	chaperone-mediated protein folding
GO_0000413	Biological process	protein peptidyl-prolyl isomerization
GO_0009617	Biological process	response to bacterium
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005528	Molecular function	FK506 binding
GO_0031072	Molecular function	heat shock protein binding
GO_0030674	Molecular function	protein-macromolecule adaptor activity
GO_0005515	Molecular function	protein binding
GO_0003755	Molecular function	peptidyl-prolyl cis-trans isomerase activity

IV. Literature review

[source]

Gene name	FKBP5
Protein name	Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) Alternative protein FKBP5 peptidylprolyl isomerase (EC 5.2.1.8)
Synonyms	AIG6 FKBP51
Description	FUNCTION: Immunophilin protein with PPIase and co-chaperone activities . Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded . Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 . Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production . .
Accessions	ENST00000542713.1 [Q13451-2] ENST00000539068.5 [Q13451-1] ENST00000357266.9 [Q13451-1] Q13451 L8EC85 Q2TA84 L0R859 ENST00000536438.5 [Q13451-1]

FKBP5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review