EMC10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0001525Biological processangiogenesis
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0071816Biological processtail-anchored membrane protein insertion into ER membrane
GO_0045050Biological processprotein insertion into ER membrane by stop-transfer membrane-anchor sequence
GO_0045766Biological processpositive regulation of angiogenesis
GO_0072546Cellular componentEMC complex
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0032977Molecular functionmembrane insertase activity

IV. Literature review

[source]
Gene nameEMC10
Protein nameER membrane protein complex subunit 10 (Hematopoietic signal peptide-containing membrane domain-containing protein 1)
ER membrane protein complex subunit 10
SynonymsUNQ764/PRO1556
INM02
C19orf63
DescriptionFUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins . Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues . Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices . It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes . By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors . By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways . .

AccessionsENST00000334976.11 [Q5UCC4-1]
ENST00000376918.7 [Q5UCC4-2]
M0QYY4
Q5UCC4
ENST00000598585.1
M0R030
ENST00000601780.5
ENST00000597799.1
M0R2A0
ENST00000599293.1
ENST00000597426.1
M0R1B7