EIF3J report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001732Biological processformation of cytoplasmic translation initiation complex
GO_0006413Biological processtranslational initiation
GO_0033290Cellular componenteukaryotic 48S preinitiation complex
GO_0005829Cellular componentcytosol
GO_0016282Cellular componenteukaryotic 43S preinitiation complex
GO_0005852Cellular componenteukaryotic translation initiation factor 3 complex
GO_0003743Molecular functiontranslation initiation factor activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEIF3J
Protein nameEukaryotic translation initiation factor 3 subunit J
Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35)
SynonymsEIF3S1
PRO0391
DescriptionFUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis . The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression . .

AccessionsENST00000535391.5 [O75822-2]
H0YLP3
ENST00000536248.1
ENST00000261868.10 [O75822-1]
O75822
ENST00000558353.1
H0YGJ7
ENST00000424492.7 [O75822-3]