DERL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006986Biological processresponse to unfolded protein
GO_0030970Biological processretrograde protein transport, ER to cytosol
GO_0045184Biological processestablishment of protein localization
GO_0071218Biological processcellular response to misfolded protein
GO_0031648Biological processprotein destabilization
GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0036503Biological processERAD pathway
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0036502Cellular componentDerlin-1-VIMP complex
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005769Cellular componentearly endosome
GO_0044322Cellular componentendoplasmic reticulum quality control compartment
GO_0005783Cellular componentendoplasmic reticulum
GO_0005770Cellular componentlate endosome
GO_0036513Cellular componentDerlin-1 retrotranslocation complex
GO_0038023Molecular functionsignaling receptor activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0002020Molecular functionprotease binding
GO_0042288Molecular functionMHC class I protein binding
GO_0005047Molecular functionsignal recognition particle binding
GO_0051117Molecular functionATPase binding
GO_0005515Molecular functionprotein binding
GO_1990381Molecular functionubiquitin-specific protease binding

IV. Literature review

[source]
Gene nameDERL1
Protein nameDer1-like domain family, member 1, isoform CRA_b (cDNA, FLJ94261)
Derlin
Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1)
SynonymsDER1
UNQ243/PRO276
hCG_2009023
DescriptionFUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins . Forms homotetramers which encircle a large channel traversing the endoplasmic reticulum (ER) membrane . This allows the retrotranslocation of misfolded proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome . The channel has a lateral gate within the membrane which provides direct access to membrane proteins with no need to reenter the ER lumen first . May mediate the interaction between VCP and the misfolded protein . Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation . By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway . .; FUNCTION: (Microbial infection) In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. .

FUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. .

FUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. .

AccessionsENST00000523036.1
ENST00000405944.7 [Q9BUN8-2]
B2R979
E5RGY0
Q9BUN8
ENST00000519018.5
ENST00000419562.6
ENST00000259512.9 [Q9BUN8-1]
B4E1G1