CRBN | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	31 studies	26% ± 9%	Explore
natural killer cell	23 studies	23% ± 6%	Explore
CD4-positive, alpha-beta T cell	20 studies	24% ± 11%	Explore
mast cell	19 studies	27% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	24% ± 7%	Explore
endothelial cell of lymphatic vessel	12 studies	24% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	24% ± 6%	Explore
CD8-positive, alpha-beta T cell	12 studies	25% ± 8%	Explore
mature NK T cell	12 studies	21% ± 5%	Explore
T cell	11 studies	21% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	25% ± 8%	Explore
fibroblast	11 studies	20% ± 5%	Explore
gamma-delta T cell	11 studies	23% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	24% ± 9%	Explore
capillary endothelial cell	10 studies	21% ± 4%	Explore
vein endothelial cell	9 studies	21% ± 7%	Explore
macrophage	9 studies	20% ± 5%	Explore
oligodendrocyte	9 studies	27% ± 9%	Explore
glutamatergic neuron	8 studies	39% ± 26%	Explore
mucosal invariant T cell	8 studies	19% ± 2%	Explore
regulatory T cell	8 studies	21% ± 2%	Explore
endothelial cell of vascular tree	8 studies	22% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	26% ± 11%	Explore
endothelial cell of artery	7 studies	22% ± 4%	Explore
astrocyte	7 studies	26% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	22% ± 6%	Explore
GABAergic neuron	7 studies	37% ± 20%	Explore
B cell	6 studies	24% ± 6%	Explore
epithelial cell	6 studies	31% ± 12%	Explore
interneuron	6 studies	34% ± 21%	Explore
pericyte	5 studies	21% ± 3%	Explore
smooth muscle cell	5 studies	17% ± 2%	Explore
oligodendrocyte precursor cell	5 studies	28% ± 10%	Explore
platelet	5 studies	20% ± 3%	Explore
memory B cell	5 studies	16% ± 1%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	24% ± 4%	Explore
naive B cell	4 studies	16% ± 0%	Explore
non-classical monocyte	4 studies	33% ± 13%	Explore
classical monocyte	4 studies	29% ± 11%	Explore
neuron	4 studies	33% ± 11%	Explore
ciliated cell	4 studies	24% ± 5%	Explore
lymphocyte	4 studies	23% ± 4%	Explore
innate lymphoid cell	4 studies	21% ± 3%	Explore
type I pneumocyte	4 studies	17% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	30% ± 17%	Explore
basal cell	4 studies	28% ± 7%	Explore
hematopoietic stem cell	4 studies	20% ± 1%	Explore
leukocyte	3 studies	18% ± 4%	Explore
glomerular endothelial cell	3 studies	28% ± 7%	Explore
microglial cell	3 studies	22% ± 4%	Explore
myofibroblast cell	3 studies	17% ± 0%	Explore
retina horizontal cell	3 studies	23% ± 8%	Explore
rod bipolar cell	3 studies	18% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	20% ± 3%	Explore
abnormal cell	3 studies	20% ± 3%	Explore
intestinal crypt stem cell	3 studies	17% ± 2%	Explore
T follicular helper cell	3 studies	23% ± 3%	Explore
adipocyte	3 studies	21% ± 6%	Explore
plasmacytoid dendritic cell	3 studies	19% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	24% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	24% ± 5%	Explore
double negative thymocyte	3 studies	29% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	25% ± 8%	Explore
brain	10 studies	33% ± 19%	Explore
lung	7 studies	20% ± 3%	Explore
eye	4 studies	24% ± 5%	Explore
liver	3 studies	25% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	1915.14	21 / 21	100%	10.26	504 / 504
brain	100%	2080.29	2642 / 2642	100%	19.97	705 / 705
breast	100%	2186.41	459 / 459	100%	14.42	1118 / 1118
esophagus	100%	1655.15	1445 / 1445	100%	7.50	183 / 183
lung	100%	1803.69	578 / 578	100%	8.95	1155 / 1155
ovary	100%	2104.41	180 / 180	100%	10.88	430 / 430
prostate	100%	1700.22	245 / 245	100%	13.23	502 / 502
thymus	100%	1875.99	653 / 653	100%	15.16	605 / 605
uterus	100%	2087.41	170 / 170	100%	9.01	459 / 459
liver	100%	938.55	226 / 226	100%	7.14	405 / 406
stomach	100%	1379.24	359 / 359	100%	9.81	285 / 286
adrenal gland	100%	1570.13	258 / 258	100%	9.99	229 / 230
intestine	100%	1966.99	966 / 966	99%	10.03	524 / 527
kidney	100%	1291.22	89 / 89	99%	11.04	895 / 901
pancreas	99%	1010.55	325 / 328	99%	9.38	177 / 178
skin	100%	1543.58	1808 / 1809	93%	9.91	439 / 472
adipose	100%	2148.82	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2115.96	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	9.44	29 / 29
spleen	100%	2064.40	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	8.62	45 / 45
ureter	0%	0	0 / 0	100%	3.97	1 / 1
muscle	100%	1872.68	802 / 803	0%	0	0 / 0
heart	98%	1183.00	845 / 861	0%	0	0 / 0
peripheral blood	89%	1015.10	830 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	76%	4.98	61 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016567	Biological process	protein ubiquitination
GO_0031333	Biological process	negative regulation of protein-containing complex assembly
GO_0034766	Biological process	negative regulation of monoatomic ion transmembrane transport
GO_0035641	Biological process	locomotory exploration behavior
GO_0031334	Biological process	positive regulation of protein-containing complex assembly
GO_0030177	Biological process	positive regulation of Wnt signaling pathway
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005829	Cellular component	cytosol
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0031464	Cellular component	Cul4A-RING E3 ubiquitin ligase complex
GO_0005634	Cellular component	nucleus
GO_0044325	Molecular function	transmembrane transporter binding
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	CRBN
Protein name	Protein cereblon Cereblon
Synonyms	AD-006
Description	FUNCTION: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 or ILF2 . Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 . Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons . Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 . May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (By similarity). Plays a negative role in TLR4 signaling by interacting with TRAF6 and ECSIT, leading to inhibition of ECSIT ubiquitination, an important step of the signaling . .
Accessions	ENST00000231948.9 [Q96SW2-1] ENST00000639284.1 ENST00000424814.5 A0A1W2PPJ5 J3QT87 ENST00000432408.6 [Q96SW2-2] Q96SW2 ENST00000450014.1 J3QT51

CRBN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review