COA3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
ciliated cell	16 studies	45% ± 20%	Explore
epithelial cell	16 studies	43% ± 20%	Explore
endothelial cell	15 studies	25% ± 11%	Explore
fibroblast	14 studies	26% ± 10%	Explore
natural killer cell	14 studies	21% ± 6%	Explore
classical monocyte	12 studies	24% ± 6%	Explore
pericyte	11 studies	25% ± 8%	Explore
smooth muscle cell	11 studies	25% ± 6%	Explore
basal cell	10 studies	34% ± 18%	Explore
CD8-positive, alpha-beta T cell	10 studies	19% ± 4%	Explore
macrophage	9 studies	23% ± 9%	Explore
non-classical monocyte	9 studies	25% ± 8%	Explore
connective tissue cell	9 studies	28% ± 8%	Explore
goblet cell	9 studies	28% ± 11%	Explore
progenitor cell	8 studies	37% ± 10%	Explore
club cell	7 studies	25% ± 9%	Explore
epithelial cell of proximal tubule	7 studies	44% ± 12%	Explore
myofibroblast cell	7 studies	26% ± 4%	Explore
abnormal cell	7 studies	29% ± 14%	Explore
endothelial cell of lymphatic vessel	7 studies	25% ± 9%	Explore
regulatory T cell	7 studies	20% ± 3%	Explore
plasma cell	6 studies	29% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	20% ± 4%	Explore
kidney loop of Henle epithelial cell	6 studies	48% ± 12%	Explore
renal alpha-intercalated cell	6 studies	71% ± 21%	Explore
endothelial cell of artery	6 studies	16% ± 1%	Explore
enterocyte	6 studies	30% ± 6%	Explore
intestinal crypt stem cell	6 studies	32% ± 12%	Explore
B cell	6 studies	20% ± 6%	Explore
secretory cell	5 studies	28% ± 16%	Explore
conventional dendritic cell	5 studies	29% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	57% ± 8%	Explore
capillary endothelial cell	5 studies	21% ± 7%	Explore
transit amplifying cell	5 studies	37% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	21% ± 5%	Explore
neuron	5 studies	37% ± 17%	Explore
type II pneumocyte	5 studies	40% ± 16%	Explore
mature NK T cell	4 studies	17% ± 1%	Explore
T cell	4 studies	29% ± 24%	Explore
enteroendocrine cell	4 studies	39% ± 12%	Explore
mesothelial cell	4 studies	35% ± 16%	Explore
vein endothelial cell	4 studies	22% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	20% ± 1%	Explore
brush cell	4 studies	17% ± 2%	Explore
plasmablast	3 studies	49% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	18% ± 2%	Explore
deuterosomal cell	3 studies	27% ± 3%	Explore
ionocyte	3 studies	27% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
hematopoietic precursor cell	3 studies	28% ± 3%	Explore
neural crest cell	3 studies	28% ± 6%	Explore
retinal ganglion cell	3 studies	57% ± 25%	Explore
renal principal cell	3 studies	64% ± 15%	Explore
type I pneumocyte	3 studies	41% ± 7%	Explore
amacrine cell	3 studies	36% ± 15%	Explore
serous secreting cell	3 studies	30% ± 2%	Explore
erythroblast	3 studies	26% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
exhausted T cell	3 studies	19% ± 3%	Explore
intermediate monocyte	3 studies	28% ± 5%	Explore
dendritic cell	3 studies	30% ± 6%	Explore
oligodendrocyte precursor cell	3 studies	31% ± 10%	Explore
hematopoietic stem cell	3 studies	18% ± 0%	Explore
CD4-positive, alpha-beta T cell	3 studies	20% ± 1%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	30% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	10 studies	31% ± 12%	Explore
kidney	9 studies	27% ± 7%	Explore
intestine	9 studies	27% ± 10%	Explore
peripheral blood	8 studies	18% ± 2%	Explore
eye	3 studies	26% ± 9%	Explore
brain	3 studies	21% ± 4%	Explore
liver	3 studies	30% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2406.23	1445 / 1445	100%	81.84	183 / 183
kidney	100%	5703.94	89 / 89	100%	142.85	901 / 901
liver	100%	2436.34	226 / 226	100%	128.21	406 / 406
ovary	100%	1553.34	180 / 180	100%	91.76	430 / 430
pancreas	100%	2560.48	328 / 328	100%	82.93	178 / 178
prostate	100%	2598.07	245 / 245	100%	129.92	502 / 502
thymus	100%	1833.06	653 / 653	100%	89.48	605 / 605
uterus	100%	1721.52	170 / 170	100%	113.96	459 / 459
brain	100%	2602.21	2641 / 2642	100%	108.04	704 / 705
skin	100%	1667.01	1808 / 1809	100%	83.06	471 / 472
intestine	100%	2630.78	965 / 966	100%	127.91	526 / 527
stomach	100%	2752.24	359 / 359	100%	114.11	285 / 286
bladder	100%	1803.81	21 / 21	100%	112.34	502 / 504
breast	100%	1918.49	459 / 459	99%	102.93	1109 / 1118
adrenal gland	100%	2038.78	258 / 258	98%	59.10	226 / 230
lung	98%	1420.31	568 / 578	100%	97.58	1152 / 1155
adipose	100%	1744.11	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	87.27	80 / 80
lymph node	0%	0	0 / 0	100%	92.23	29 / 29
spleen	100%	1454.94	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	112.93	45 / 45
ureter	0%	0	0 / 0	100%	63.74	1 / 1
muscle	100%	1997.13	802 / 803	0%	0	0 / 0
blood vessel	99%	1501.27	1328 / 1335	0%	0	0 / 0
heart	99%	1780.34	851 / 861	0%	0	0 / 0
peripheral blood	72%	662.11	673 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0070131	Biological process	positive regulation of mitochondrial translation
GO_0033617	Biological process	mitochondrial cytochrome c oxidase assembly
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	COA3
Protein name	Cytochrome c oxidase assembly factor 3 Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (Coiled-coil domain-containing protein 56) (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa)
Synonyms	MITRAC12 HSPC009 CCDC56
Description	FUNCTION: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly. .
Accessions	ENST00000328434.8 ENST00000586680.1 K7EPV0 Q9Y2R0

COA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review