CNOT4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	27 studies	29% ± 12%	Explore
fibroblast	21 studies	26% ± 9%	Explore
astrocyte	15 studies	37% ± 16%	Explore
smooth muscle cell	15 studies	20% ± 5%	Explore
natural killer cell	13 studies	21% ± 5%	Explore
pericyte	13 studies	23% ± 8%	Explore
B cell	12 studies	21% ± 6%	Explore
macrophage	12 studies	30% ± 12%	Explore
glutamatergic neuron	11 studies	42% ± 25%	Explore
microglial cell	11 studies	32% ± 12%	Explore
oligodendrocyte precursor cell	11 studies	39% ± 18%	Explore
oligodendrocyte	11 studies	33% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	20% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	18% ± 3%	Explore
adipocyte	10 studies	32% ± 9%	Explore
naive B cell	9 studies	19% ± 3%	Explore
GABAergic neuron	9 studies	43% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	20% ± 4%	Explore
epithelial cell	9 studies	32% ± 18%	Explore
CD8-positive, alpha-beta T cell	8 studies	20% ± 3%	Explore
gamma-delta T cell	8 studies	19% ± 6%	Explore
T cell	7 studies	22% ± 4%	Explore
endothelial cell of lymphatic vessel	7 studies	28% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	18% ± 3%	Explore
myofibroblast cell	7 studies	21% ± 6%	Explore
type I pneumocyte	7 studies	24% ± 7%	Explore
CD4-positive, alpha-beta T cell	6 studies	21% ± 2%	Explore
mature NK T cell	6 studies	19% ± 3%	Explore
neuron	6 studies	42% ± 15%	Explore
interneuron	6 studies	47% ± 22%	Explore
mucosal invariant T cell	6 studies	18% ± 2%	Explore
amacrine cell	6 studies	27% ± 7%	Explore
retinal cone cell	6 studies	33% ± 11%	Explore
retinal rod cell	6 studies	27% ± 5%	Explore
dendritic cell	6 studies	25% ± 7%	Explore
mast cell	6 studies	23% ± 4%	Explore
ciliated cell	6 studies	27% ± 7%	Explore
Mueller cell	6 studies	26% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	18% ± 1%	Explore
basal cell	6 studies	30% ± 16%	Explore
regulatory T cell	6 studies	18% ± 2%	Explore
type II pneumocyte	6 studies	24% ± 5%	Explore
myeloid cell	5 studies	23% ± 4%	Explore
retina horizontal cell	5 studies	24% ± 6%	Explore
abnormal cell	5 studies	25% ± 12%	Explore
monocyte	5 studies	27% ± 6%	Explore
club cell	5 studies	24% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	19% ± 4%	Explore
capillary endothelial cell	4 studies	18% ± 4%	Explore
granule cell	4 studies	30% ± 8%	Explore
retinal bipolar neuron	4 studies	25% ± 4%	Explore
retinal pigment epithelial cell	4 studies	31% ± 19%	Explore
cardiac muscle cell	4 studies	24% ± 1%	Explore
lymphocyte	4 studies	32% ± 8%	Explore
connective tissue cell	4 studies	22% ± 3%	Explore
leukocyte	3 studies	29% ± 9%	Explore
non-classical monocyte	3 studies	23% ± 6%	Explore
GABAergic interneuron	3 studies	30% ± 3%	Explore
glial cell	3 studies	27% ± 3%	Explore
retinal ganglion cell	3 studies	24% ± 4%	Explore
precursor B cell	3 studies	21% ± 2%	Explore
plasma cell	3 studies	28% ± 3%	Explore
mesothelial cell	3 studies	36% ± 13%	Explore
mononuclear phagocyte	3 studies	25% ± 9%	Explore
vein endothelial cell	3 studies	27% ± 14%	Explore
GABAergic amacrine cell	3 studies	23% ± 3%	Explore
OFF-bipolar cell	3 studies	26% ± 5%	Explore
ON-bipolar cell	3 studies	23% ± 5%	Explore
glycinergic amacrine cell	3 studies	24% ± 4%	Explore
rod bipolar cell	3 studies	26% ± 8%	Explore
memory B cell	3 studies	18% ± 2%	Explore
endothelial cell of vascular tree	3 studies	29% ± 15%	Explore
hepatocyte	3 studies	40% ± 16%	Explore
neural progenitor cell	3 studies	28% ± 9%	Explore
ependymal cell	3 studies	37% ± 16%	Explore
adventitial cell	3 studies	19% ± 3%	Explore
alveolar macrophage	3 studies	32% ± 9%	Explore
goblet cell	3 studies	38% ± 28%	Explore
transit amplifying cell	3 studies	33% ± 22%	Explore
plasmacytoid dendritic cell	3 studies	22% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	19% ± 3%	Explore
myoepithelial cell	3 studies	21% ± 7%	Explore
mural cell	3 studies	33% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	35% ± 20%	Explore
lung	10 studies	22% ± 7%	Explore
eye	8 studies	28% ± 11%	Explore
peripheral blood	4 studies	21% ± 4%	Explore
heart	4 studies	22% ± 3%	Explore
liver	4 studies	27% ± 12%	Explore
adipose	4 studies	30% ± 10%	Explore
intestine	3 studies	21% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1422.32	1445 / 1445	100%	13.96	183 / 183
ovary	100%	1635.36	180 / 180	100%	15.37	430 / 430
prostate	100%	1492.40	245 / 245	100%	11.87	502 / 502
uterus	100%	1706.42	170 / 170	100%	10.95	459 / 459
brain	100%	1508.52	2640 / 2642	100%	21.07	705 / 705
lung	100%	1448.49	578 / 578	100%	12.20	1154 / 1155
thymus	100%	1640.27	653 / 653	100%	13.35	604 / 605
bladder	100%	1566.05	21 / 21	100%	9.75	503 / 504
breast	100%	1479.71	459 / 459	100%	15.67	1115 / 1118
adrenal gland	100%	1247.60	258 / 258	99%	11.42	228 / 230
kidney	100%	1127.61	89 / 89	99%	12.96	893 / 901
skin	100%	1498.91	1808 / 1809	99%	15.10	468 / 472
intestine	100%	1446.01	966 / 966	99%	10.48	522 / 527
stomach	100%	1003.90	359 / 359	99%	11.76	283 / 286
pancreas	99%	679.04	326 / 328	99%	9.92	177 / 178
liver	100%	720.66	226 / 226	96%	6.86	391 / 406
adipose	100%	1587.31	1204 / 1204	0%	0	0 / 0
blood vessel	100%	1605.59	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	10.16	29 / 29
muscle	100%	2184.88	803 / 803	0%	0	0 / 0
spleen	100%	1250.63	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	11.34	45 / 45
ureter	0%	0	0 / 0	100%	3.77	1 / 1
heart	98%	1113.95	847 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	93%	7.83	74 / 80
peripheral blood	88%	851.74	817 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000289	Biological process	nuclear-transcribed mRNA poly(A) tail shortening
GO_0051865	Biological process	protein autoubiquitination
GO_0016567	Biological process	protein ubiquitination
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0045652	Biological process	regulation of megakaryocyte differentiation
GO_0030014	Cellular component	CCR4-NOT complex
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	CNOT4
Protein name	CCR4-NOT transcription complex subunit 4 CCR4-NOT transcription complex subunit 4 (EC 2.3.2.27) (CCR4-associated factor 4) (E3 ubiquitin-protein ligase CNOT4) (Potential transcriptional repressor NOT4Hp) (RING-type E3 ubiquitin transferase CNOT4)
Synonyms	NOT4
Description	FUNCTION: Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins . Involved in activation of the JAK/STAT pathway . Catalyzes ubiquitination of methylated RBM15 . Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA . As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy . .
Accessions	ENST00000707064.1 [O95628-1] A0A9L9PY79 A0A9L9PY48 ENST00000541284.6 [O95628-10] ENST00000414802.5 [O95628-5] ENST00000315544.6 [O95628-1] ENST00000707063.1 ENST00000451834.5 [O95628-9] ENST00000423368.6 [O95628-4] ENST00000707062.1 ENST00000428680.6 [O95628-2] ENST00000361528.8 [O95628-8] O95628

CNOT4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review