CD48 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	37 studies	56% ± 19%	Explore
natural killer cell	37 studies	51% ± 13%	Explore
CD8-positive, alpha-beta T cell	36 studies	55% ± 17%	Explore
CD4-positive, alpha-beta T cell	32 studies	59% ± 17%	Explore
T cell	30 studies	47% ± 18%	Explore
conventional dendritic cell	27 studies	51% ± 19%	Explore
classical monocyte	26 studies	56% ± 16%	Explore
regulatory T cell	26 studies	54% ± 15%	Explore
non-classical monocyte	24 studies	71% ± 20%	Explore
monocyte	22 studies	47% ± 16%	Explore
mature NK T cell	20 studies	56% ± 14%	Explore
memory B cell	20 studies	63% ± 15%	Explore
macrophage	20 studies	27% ± 10%	Explore
naive B cell	19 studies	56% ± 12%	Explore
gamma-delta T cell	18 studies	57% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	66% ± 18%	Explore
mucosal invariant T cell	16 studies	61% ± 22%	Explore
plasma cell	15 studies	34% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	54% ± 12%	Explore
dendritic cell	14 studies	55% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	53% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	74% ± 12%	Explore
mast cell	12 studies	30% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	61% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	60% ± 20%	Explore
plasmacytoid dendritic cell	11 studies	28% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	63% ± 23%	Explore
plasmablast	10 studies	45% ± 18%	Explore
leukocyte	9 studies	39% ± 15%	Explore
T follicular helper cell	9 studies	53% ± 17%	Explore
innate lymphoid cell	9 studies	43% ± 18%	Explore
myeloid cell	9 studies	36% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	63% ± 12%	Explore
CD4-positive helper T cell	6 studies	46% ± 19%	Explore
neutrophil	6 studies	26% ± 8%	Explore
platelet	6 studies	33% ± 21%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	64% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	72% ± 17%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	64% ± 28%	Explore
exhausted T cell	5 studies	62% ± 20%	Explore
immature B cell	5 studies	48% ± 11%	Explore
intermediate monocyte	5 studies	62% ± 28%	Explore
mononuclear phagocyte	4 studies	54% ± 17%	Explore
hematopoietic precursor cell	4 studies	31% ± 9%	Explore
IgA plasma cell	4 studies	29% ± 9%	Explore
lymphocyte	4 studies	28% ± 10%	Explore
precursor B cell	4 studies	31% ± 16%	Explore
T-helper 17 cell	4 studies	67% ± 12%	Explore
T-helper 1 cell	4 studies	70% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	62% ± 12%	Explore
double negative thymocyte	4 studies	67% ± 16%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	50% ± 24%	Explore
monocyte-derived dendritic cell	3 studies	53% ± 26%	Explore
thymocyte	3 studies	36% ± 10%	Explore
intraepithelial lymphocyte	3 studies	48% ± 9%	Explore
germinal center B cell	3 studies	33% ± 7%	Explore
granulocyte	3 studies	51% ± 22%	Explore
group 3 innate lymphoid cell	3 studies	45% ± 19%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	82% ± 8%	Explore
double-positive, alpha-beta thymocyte	3 studies	68% ± 20%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	60% ± 16%	Explore
lung	5 studies	37% ± 5%	Explore
bone marrow	5 studies	32% ± 18%	Explore
intestine	4 studies	33% ± 14%	Explore
lymph node	4 studies	41% ± 20%	Explore
liver	3 studies	45% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	660.34	577 / 578	85%	7.78	981 / 1155
stomach	79%	133.02	285 / 359	72%	6.16	206 / 286
breast	68%	106.76	314 / 459	79%	6.69	882 / 1118
prostate	80%	159.71	197 / 245	52%	2.46	263 / 502
kidney	55%	125.24	49 / 89	77%	6.64	692 / 901
intestine	69%	456.35	662 / 966	63%	4.83	332 / 527
thymus	71%	159.15	463 / 653	52%	6.93	312 / 605
bladder	67%	171.29	14 / 21	54%	4.11	273 / 504
uterus	53%	55.56	90 / 170	58%	3.62	265 / 459
lymph node	0%	0	0 / 0	100%	79.67	29 / 29
peripheral blood	100%	9206.93	929 / 929	0%	0	0 / 0
spleen	100%	3686.15	241 / 241	0%	0	0 / 0
liver	65%	80.09	146 / 226	35%	2.23	143 / 406
esophagus	48%	64.22	698 / 1445	50%	2.93	92 / 183
adipose	89%	199.34	1076 / 1204	0%	0	0 / 0
pancreas	15%	17.59	49 / 328	72%	6.66	128 / 178
skin	14%	13.41	249 / 1809	68%	8.40	319 / 472
tonsil	0%	0	0 / 0	80%	9.06	36 / 45
ovary	13%	14.63	23 / 180	67%	4.10	288 / 430
adrenal gland	31%	32.30	79 / 258	13%	0.43	31 / 230
blood vessel	41%	82.60	543 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	35%	3.60	28 / 80
brain	7%	9.80	182 / 2642	23%	1.25	165 / 705
heart	21%	25.02	181 / 861	0%	0	0 / 0
muscle	1%	1.08	8 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006952	Biological process	defense response
GO_0045121	Cellular component	membrane raft
GO_0098552	Cellular component	side of membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CD48
Protein name	CD48 molecule CD48 protein CD48 antigen (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (SLAM family member 2) (SLAMF2) (Signaling lymphocytic activation molecule 2) (TCT.1) (CD antigen CD48)
Synonyms	BLAST1 BCM1
Description	FUNCTION: Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation . Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex . In turn, promotes LCK phosphorylation and subsequent activation . Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells . .
Accessions	Q6IAZ2 A0A087X1S7 P09326 ENST00000368046.8 [P09326-1] ENST00000368045.3 [P09326-2] ENST00000613788.1

CD48 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review