CALCOCO2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016032Biological processviral process
GO_0098792Biological processxenophagy
GO_1901098Biological processpositive regulation of autophagosome maturation
GO_0034341Biological processresponse to type II interferon
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000421Cellular componentautophagosome membrane
GO_0005856Cellular componentcytoskeleton
GO_0005829Cellular componentcytosol
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0016605Cellular componentPML body
GO_0005776Cellular componentautophagosome
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameCALCOCO2
Protein nameCalcium-binding and coiled-coil domain-containing protein 2 (Nuclear domain 10 protein NDP52)
Calcium binding and coiled-coil domain 2
Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52)
SynonymsNDP52
DescriptionFUNCTION: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy . Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation . Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C . May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion . .

AccessionsENST00000448105.6 [Q13137-4]
ENST00000509415.5
ENST00000416445.6 [Q13137-2]
ENST00000509784.1
H0Y9G3
D6RBI4
D6RF70
Q13137
ENST00000509507.5 [Q13137-3]
ENST00000513119.5
D6RJE7
I3L493
D6REB0
ENST00000502761.1
ENST00000507306.1
D6RBF9
ENST00000507076.1
ENST00000258947.8 [Q13137-1]
ENST00000505071.5
ENST00000508679.5 [Q13137-5]
ENST00000570513.5
I3L4E1
ENST00000576582.5
H0YBP4