BEX4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
mast cell	19 studies	36% ± 13%	Explore
fibroblast	17 studies	27% ± 12%	Explore
endothelial cell	16 studies	31% ± 12%	Explore
macrophage	15 studies	22% ± 7%	Explore
natural killer cell	13 studies	20% ± 4%	Explore
smooth muscle cell	12 studies	32% ± 9%	Explore
glutamatergic neuron	11 studies	35% ± 18%	Explore
plasmacytoid dendritic cell	11 studies	27% ± 8%	Explore
epithelial cell	10 studies	38% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	25% ± 5%	Explore
connective tissue cell	9 studies	34% ± 14%	Explore
conventional dendritic cell	9 studies	21% ± 7%	Explore
neuron	9 studies	49% ± 26%	Explore
pericyte	9 studies	30% ± 10%	Explore
astrocyte	9 studies	30% ± 19%	Explore
oligodendrocyte	9 studies	26% ± 11%	Explore
endothelial cell of lymphatic vessel	8 studies	26% ± 8%	Explore
basal cell	8 studies	32% ± 18%	Explore
oligodendrocyte precursor cell	8 studies	35% ± 13%	Explore
myofibroblast cell	7 studies	34% ± 9%	Explore
ciliated cell	7 studies	28% ± 10%	Explore
GABAergic neuron	7 studies	38% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	22% ± 6%	Explore
CD4-positive, alpha-beta T cell	6 studies	24% ± 8%	Explore
mesothelial cell	6 studies	50% ± 18%	Explore
hematopoietic stem cell	6 studies	27% ± 9%	Explore
interneuron	6 studies	35% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	21% ± 4%	Explore
kidney loop of Henle epithelial cell	5 studies	36% ± 6%	Explore
amacrine cell	5 studies	52% ± 27%	Explore
type II pneumocyte	5 studies	35% ± 17%	Explore
retina horizontal cell	5 studies	46% ± 23%	Explore
innate lymphoid cell	5 studies	22% ± 4%	Explore
hematopoietic precursor cell	4 studies	38% ± 20%	Explore
pancreatic A cell	4 studies	67% ± 12%	Explore
type B pancreatic cell	4 studies	67% ± 15%	Explore
B cell	4 studies	22% ± 4%	Explore
mature NK T cell	4 studies	18% ± 2%	Explore
progenitor cell	4 studies	35% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	48% ± 11%	Explore
T cell	4 studies	32% ± 18%	Explore
epithelial cell of proximal tubule	4 studies	30% ± 11%	Explore
abnormal cell	4 studies	25% ± 6%	Explore
enteroendocrine cell	4 studies	39% ± 23%	Explore
retinal ganglion cell	4 studies	79% ± 23%	Explore
microglial cell	4 studies	25% ± 10%	Explore
dendritic cell	4 studies	32% ± 16%	Explore
regulatory T cell	4 studies	19% ± 5%	Explore
secretory cell	4 studies	26% ± 7%	Explore
pancreatic D cell	3 studies	78% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	26% ± 8%	Explore
podocyte	3 studies	69% ± 11%	Explore
renal alpha-intercalated cell	3 studies	35% ± 6%	Explore
endothelial cell of artery	3 studies	23% ± 6%	Explore
neural crest cell	3 studies	36% ± 12%	Explore
vein endothelial cell	3 studies	30% ± 7%	Explore
retinal bipolar neuron	3 studies	57% ± 19%	Explore
OFF-bipolar cell	3 studies	51% ± 29%	Explore
ON-bipolar cell	3 studies	50% ± 29%	Explore
GABAergic amacrine cell	3 studies	42% ± 15%	Explore
glycinergic amacrine cell	3 studies	30% ± 12%	Explore
placental villous trophoblast	3 studies	45% ± 23%	Explore
capillary endothelial cell	3 studies	31% ± 12%	Explore
type I pneumocyte	3 studies	37% ± 11%	Explore
retinal rod cell	3 studies	27% ± 8%	Explore
alveolar macrophage	3 studies	19% ± 1%	Explore
myeloid cell	3 studies	25% ± 7%	Explore
Mueller cell	3 studies	43% ± 9%	Explore
rod bipolar cell	3 studies	41% ± 19%	Explore
granulocyte	3 studies	32% ± 13%	Explore
platelet	3 studies	19% ± 4%	Explore
pancreatic ductal cell	3 studies	50% ± 14%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	48% ± 22%	Explore
glial cell	3 studies	39% ± 26%	Explore
T follicular helper cell	3 studies	19% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	29% ± 8%	Explore
naive B cell	3 studies	18% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	26% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	29% ± 14%	Explore
eye	8 studies	32% ± 13%	Explore
lung	8 studies	25% ± 9%	Explore
pancreas	4 studies	57% ± 19%	Explore
peripheral blood	4 studies	17% ± 1%	Explore
kidney	4 studies	26% ± 7%	Explore
intestine	4 studies	35% ± 12%	Explore
lymph node	4 studies	19% ± 3%	Explore
placenta	3 studies	36% ± 9%	Explore
uterus	3 studies	27% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	10807.63	2642 / 2642	99%	339.34	701 / 705
prostate	100%	3773.10	244 / 245	100%	182.98	500 / 502
adrenal gland	100%	3204.88	258 / 258	99%	385.51	227 / 230
thymus	100%	5489.53	652 / 653	98%	308.82	594 / 605
ovary	100%	4332.03	180 / 180	97%	144.77	419 / 430
kidney	100%	3485.43	89 / 89	91%	112.83	819 / 901
breast	97%	2382.46	443 / 459	91%	110.99	1015 / 1118
bladder	100%	2575.48	21 / 21	67%	83.66	338 / 504
lung	97%	2005.18	563 / 578	69%	66.13	794 / 1155
uterus	100%	3302.24	170 / 170	54%	75.69	250 / 459
skin	68%	976.05	1226 / 1809	83%	106.17	390 / 472
esophagus	98%	2412.96	1411 / 1445	31%	22.45	56 / 183
pancreas	33%	391.57	107 / 328	80%	74.52	142 / 178
intestine	92%	2582.52	893 / 966	19%	13.62	101 / 527
spleen	100%	2809.25	241 / 241	0%	0	0 / 0
blood vessel	98%	2478.08	1303 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	93%	107.75	74 / 80
stomach	69%	1470.26	249 / 359	20%	11.42	56 / 286
heart	89%	2390.16	763 / 861	0%	0	0 / 0
adipose	85%	1380.86	1019 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	41%	25.09	12 / 29
tonsil	0%	0	0 / 0	38%	32.56	17 / 45
liver	1%	12.10	2 / 226	22%	14.14	91 / 406
peripheral blood	12%	159.33	113 / 929	0%	0	0 / 0
muscle	0%	3.83	3 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1904428	Biological process	negative regulation of tubulin deacetylation
GO_0031397	Biological process	negative regulation of protein ubiquitination
GO_0030334	Biological process	regulation of cell migration
GO_0007059	Biological process	chromosome segregation
GO_0042127	Biological process	regulation of cell population proliferation
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005874	Cellular component	microtubule
GO_0000922	Cellular component	spindle pole
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0043014	Molecular function	alpha-tubulin binding
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding
GO_0140678	Molecular function	molecular function inhibitor activity
GO_0042826	Molecular function	histone deacetylase binding

IV. Literature review

[source]

Gene name	BEX4
Protein name	Protein BEX4 (BEX1-like protein 1) (Brain-expressed X-linked protein 4) (Nerve growth factor receptor-associated protein 3)
Synonyms	NADE3 BEXL1
Description	FUNCTION: May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability . In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). .
Accessions	ENST00000372695.6 ENST00000372691.3 Q9NWD9

BEX4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review