BAZ2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006338Biological processchromatin remodeling
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameBAZ2B
Protein nameUncharacterized protein BAZ2B
BAZ2B protein
Bromodomain adjacent to zinc finger domain 2B
Alternative protein BAZ2B
Bromodomain adjacent to zinc finger domain protein 2B (hWALp4)
SynonymsKIAA1476
DescriptionFUNCTION: Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair . Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template . The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex . Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) . Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). .

AccessionsL8EAN3
ENST00000541068.6
ENST00000392783.7 [Q9UIF8-1]
H7BXK5
ENST00000392782.5 [Q9UIF8-5]
H7C092
ENST00000441143.1
ENST00000437839.5
Q9UIF8
H7C1I6
ENST00000294905.4
Q53TG3
F6VJC3
ENST00000426648.1
Q3B7K5
C9JCA6