ATG12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000045Biological processautophagosome assembly
GO_1901096Biological processregulation of autophagosome maturation
GO_0034727Biological processpiecemeal microautophagy of the nucleus
GO_0016236Biological processmacroautophagy
GO_0032480Biological processnegative regulation of type I interferon production
GO_1904973Biological processpositive regulation of viral translation
GO_0045824Biological processnegative regulation of innate immune response
GO_0050687Biological processnegative regulation of defense response to virus
GO_0000422Biological processautophagy of mitochondrion
GO_0097352Biological processautophagosome maturation
GO_0061739Biological processprotein lipidation involved in autophagosome assembly
GO_0061723Biological processglycophagy
GO_0034045Cellular componentphagophore assembly site membrane
GO_0000421Cellular componentautophagosome membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_1990234Cellular componenttransferase complex
GO_0005776Cellular componentautophagosome
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0034274Cellular componentAtg12-Atg5-Atg16 complex
GO_0019776Molecular functionAtg8-family ligase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATG12
Protein nameUbiquitin-like protein ATG12 (Autophagy-related protein 12) (APG12-like)
Ubiquitin-like protein ATG12
Autophagy related 12
SynonymsAPG12L
hCG_36968
APG12
DescriptionFUNCTION: Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. .; FUNCTION: (Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection . Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established . .

FUNCTION: Ubiquitin-like protein involved in autophagic vesicle formation. .

AccessionsENST00000513322.5
ENST00000513167.1
H0YA29
ENST00000509910.2 [O94817-1]
D6RB14
H0Y9W4
H7BYD7
ENST00000379594.7
O94817
ENST00000500945.2 [O94817-4]
ENST00000505993.5
C1IDX9