ASXL1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	33 studies	32% ± 13%	Explore
fibroblast	17 studies	29% ± 10%	Explore
pericyte	14 studies	28% ± 12%	Explore
B cell	13 studies	27% ± 11%	Explore
astrocyte	13 studies	34% ± 12%	Explore
oligodendrocyte	12 studies	34% ± 13%	Explore
macrophage	10 studies	28% ± 11%	Explore
microglial cell	10 studies	29% ± 9%	Explore
oligodendrocyte precursor cell	10 studies	34% ± 15%	Explore
regulatory T cell	10 studies	22% ± 6%	Explore
smooth muscle cell	10 studies	25% ± 6%	Explore
endothelial cell of lymphatic vessel	9 studies	34% ± 14%	Explore
type I pneumocyte	9 studies	26% ± 11%	Explore
glutamatergic neuron	9 studies	39% ± 25%	Explore
adipocyte	9 studies	35% ± 8%	Explore
GABAergic neuron	8 studies	44% ± 19%	Explore
epithelial cell	8 studies	38% ± 15%	Explore
basal cell	8 studies	27% ± 14%	Explore
CD4-positive, alpha-beta T cell	7 studies	25% ± 7%	Explore
T cell	6 studies	25% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	23% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	23% ± 6%	Explore
neuron	6 studies	39% ± 22%	Explore
interneuron	6 studies	43% ± 21%	Explore
myeloid cell	6 studies	21% ± 3%	Explore
capillary endothelial cell	6 studies	23% ± 7%	Explore
retinal cone cell	6 studies	32% ± 12%	Explore
dendritic cell	6 studies	21% ± 9%	Explore
ciliated cell	6 studies	29% ± 9%	Explore
type II pneumocyte	6 studies	27% ± 10%	Explore
natural killer cell	5 studies	21% ± 3%	Explore
plasma cell	5 studies	33% ± 12%	Explore
plasmablast	5 studies	39% ± 16%	Explore
leukocyte	5 studies	22% ± 4%	Explore
naive B cell	5 studies	20% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	18% ± 2%	Explore
CD8-positive, alpha-beta T cell	5 studies	21% ± 5%	Explore
vein endothelial cell	5 studies	29% ± 14%	Explore
lymphocyte	5 studies	30% ± 7%	Explore
club cell	5 studies	26% ± 9%	Explore
cardiac muscle cell	4 studies	19% ± 1%	Explore
mesothelial cell	4 studies	29% ± 11%	Explore
Mueller cell	4 studies	22% ± 4%	Explore
retinal rod cell	4 studies	29% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	22% ± 4%	Explore
endothelial cell of artery	4 studies	23% ± 5%	Explore
endothelial cell of vascular tree	4 studies	30% ± 15%	Explore
abnormal cell	4 studies	33% ± 22%	Explore
monocyte	4 studies	22% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	19% ± 3%	Explore
GABAergic interneuron	3 studies	27% ± 4%	Explore
glial cell	3 studies	22% ± 3%	Explore
granule cell	3 studies	23% ± 3%	Explore
mononuclear phagocyte	3 studies	19% ± 4%	Explore
mucosal invariant T cell	3 studies	20% ± 1%	Explore
GABAergic amacrine cell	3 studies	18% ± 3%	Explore
glycinergic amacrine cell	3 studies	17% ± 1%	Explore
retina horizontal cell	3 studies	19% ± 2%	Explore
mature NK T cell	3 studies	23% ± 9%	Explore
memory B cell	3 studies	19% ± 2%	Explore
hepatocyte	3 studies	54% ± 25%	Explore
retinal pigment epithelial cell	3 studies	33% ± 17%	Explore
connective tissue cell	3 studies	28% ± 13%	Explore
ependymal cell	3 studies	48% ± 9%	Explore
mast cell	3 studies	26% ± 7%	Explore
myofibroblast cell	3 studies	40% ± 8%	Explore
alveolar macrophage	3 studies	24% ± 9%	Explore
T follicular helper cell	3 studies	21% ± 7%	Explore
transit amplifying cell	3 studies	41% ± 24%	Explore
mural cell	3 studies	33% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	34% ± 18%	Explore
lung	8 studies	23% ± 8%	Explore
eye	5 studies	31% ± 12%	Explore
peripheral blood	4 studies	30% ± 10%	Explore
heart	4 studies	22% ± 3%	Explore
intestine	4 studies	19% ± 4%	Explore
liver	3 studies	44% ± 19%	Explore
adipose	3 studies	37% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	8379.81	21 / 21	100%	19.51	504 / 504
esophagus	100%	7086.27	1445 / 1445	100%	26.45	183 / 183
ovary	100%	10131.63	180 / 180	100%	26.29	430 / 430
prostate	100%	8301.64	245 / 245	100%	16.42	502 / 502
skin	100%	7553.11	1809 / 1809	100%	30.02	472 / 472
stomach	100%	6107.08	359 / 359	100%	23.83	286 / 286
uterus	100%	10559.24	170 / 170	100%	21.90	459 / 459
lung	100%	11162.02	578 / 578	100%	20.23	1154 / 1155
breast	100%	10374.73	459 / 459	100%	22.26	1117 / 1118
intestine	100%	8726.94	966 / 966	100%	21.21	526 / 527
thymus	100%	11064.68	653 / 653	100%	18.41	603 / 605
pancreas	100%	5597.94	328 / 328	99%	18.75	177 / 178
kidney	100%	7280.45	89 / 89	99%	18.30	888 / 901
liver	100%	4862.54	226 / 226	97%	13.05	393 / 406
adrenal gland	100%	6885.73	258 / 258	96%	12.46	221 / 230
brain	94%	3390.64	2493 / 2642	100%	22.80	705 / 705
adipose	100%	10157.70	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7531.11	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	19.65	80 / 80
lymph node	0%	0	0 / 0	100%	27.27	29 / 29
spleen	100%	10446.71	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	21.04	45 / 45
ureter	0%	0	0 / 0	100%	7.41	1 / 1
muscle	100%	5557.07	801 / 803	0%	0	0 / 0
heart	98%	4159.56	844 / 861	0%	0	0 / 0
peripheral blood	84%	4225.36	779 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_0030097	Biological process	hemopoiesis
GO_0048386	Biological process	positive regulation of retinoic acid receptor signaling pathway
GO_0035564	Biological process	regulation of kidney size
GO_0009887	Biological process	animal organ morphogenesis
GO_0048539	Biological process	bone marrow development
GO_0045599	Biological process	negative regulation of fat cell differentiation
GO_0060430	Biological process	lung saccule development
GO_0048872	Biological process	homeostasis of number of cells
GO_0035359	Biological process	negative regulation of peroxisome proliferator activated receptor signaling pathway
GO_0048538	Biological process	thymus development
GO_0072015	Biological process	podocyte development
GO_0032526	Biological process	response to retinoic acid
GO_0000902	Biological process	cell morphogenesis
GO_0003007	Biological process	heart morphogenesis
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0035517	Cellular component	PR-DUB complex
GO_0003677	Molecular function	DNA binding
GO_0003682	Molecular function	chromatin binding
GO_0042974	Molecular function	nuclear retinoic acid receptor binding
GO_0042975	Molecular function	peroxisome proliferator activated receptor binding
GO_0046872	Molecular function	metal ion binding
GO_0003713	Molecular function	transcription coactivator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ASXL1
Protein name	Polycomb group protein ASXL1 (Additional sex combs-like protein 1) ASXL transcriptional regulator 1 ASXL transcriptional regulator 1 (Additional sex combs like 1 (Drosophila), isoform CRA_d) (Polycomb group protein) ASXL transcriptional regulator 1 (ASXL1 protein)
Synonyms	ASXH1 hCG_38816 KIAA0978
Description	FUNCTION: Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) . Acts as a coactivator of RARA and RXRA through association with NCOA1 . Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) . Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing . .
Accessions	ENST00000375687.10 [Q8IXJ9-1] Q76L82 ENST00000645688.1 ENST00000645035.1 ENST00000651418.1 ENST00000497249.6 ENST00000643168.1 ENST00000642676.1 A0A2R8Y4U9 Q498B9 ENST00000646985.1 H0YJC9 ENST00000555343.2 A0A2R8Y5U1 A0A494C1R1 ENST00000644587.1 ENST00000306058.9 ENST00000649901.1 A0A2R8Y627 A0A2R8Y6F0 Q6P1M8 ENST00000646367.1 A0A087WWN0 ENST00000645337.1 Q5JWS8 Q8IXJ9 A0A2R8Y6V0 ENST00000375689.5

ASXL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review