VSIR | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	29 studies	38% ± 16%	Explore
classical monocyte	26 studies	63% ± 21%	Explore
conventional dendritic cell	26 studies	49% ± 17%	Explore
non-classical monocyte	24 studies	73% ± 19%	Explore
monocyte	22 studies	52% ± 14%	Explore
natural killer cell	22 studies	25% ± 6%	Explore
endothelial cell	22 studies	28% ± 11%	Explore
CD4-positive, alpha-beta T cell	21 studies	27% ± 8%	Explore
T cell	18 studies	22% ± 7%	Explore
dendritic cell	18 studies	47% ± 22%	Explore
regulatory T cell	17 studies	31% ± 9%	Explore
CD8-positive, alpha-beta T cell	16 studies	27% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	29% ± 6%	Explore
mature NK T cell	12 studies	27% ± 8%	Explore
capillary endothelial cell	12 studies	31% ± 12%	Explore
myeloid cell	12 studies	43% ± 18%	Explore
plasma cell	10 studies	32% ± 13%	Explore
neutrophil	10 studies	58% ± 21%	Explore
plasmacytoid dendritic cell	10 studies	28% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	29% ± 4%	Explore
fibroblast	10 studies	26% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	29% ± 7%	Explore
endothelial cell of artery	9 studies	34% ± 16%	Explore
mesothelial cell	9 studies	27% ± 10%	Explore
mucosal invariant T cell	9 studies	36% ± 10%	Explore
microglial cell	9 studies	45% ± 17%	Explore
gamma-delta T cell	9 studies	26% ± 7%	Explore
platelet	8 studies	24% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	29% ± 6%	Explore
endothelial cell of vascular tree	8 studies	22% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	28% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	28% ± 6%	Explore
T follicular helper cell	6 studies	26% ± 7%	Explore
plasmablast	5 studies	33% ± 17%	Explore
mononuclear phagocyte	5 studies	51% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	31% ± 6%	Explore
hematopoietic precursor cell	5 studies	30% ± 9%	Explore
leukocyte	5 studies	32% ± 10%	Explore
hematopoietic stem cell	5 studies	21% ± 5%	Explore
epithelial cell	5 studies	32% ± 11%	Explore
type I pneumocyte	5 studies	25% ± 11%	Explore
squamous epithelial cell	4 studies	40% ± 19%	Explore
vein endothelial cell	4 studies	24% ± 8%	Explore
lymphocyte	4 studies	19% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	32% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	24% ± 7%	Explore
intermediate monocyte	4 studies	80% ± 15%	Explore
B cell	4 studies	17% ± 1%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	36% ± 6%	Explore
astrocyte	4 studies	31% ± 11%	Explore
basal cell	4 studies	31% ± 7%	Explore
exhausted T cell	3 studies	27% ± 8%	Explore
pericyte	3 studies	17% ± 1%	Explore
placental villous trophoblast	3 studies	56% ± 14%	Explore
common myeloid progenitor	3 studies	26% ± 10%	Explore
endothelial cell of lymphatic vessel	3 studies	24% ± 5%	Explore
innate lymphoid cell	3 studies	24% ± 6%	Explore
granulocyte	3 studies	24% ± 7%	Explore
enterocyte	3 studies	20% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 6%	Explore
double negative thymocyte	3 studies	25% ± 5%	Explore
secretory cell	3 studies	20% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	38% ± 9%	Explore
lung	6 studies	23% ± 4%	Explore
intestine	4 studies	18% ± 2%	Explore
placenta	3 studies	39% ± 10%	Explore
bone marrow	3 studies	26% ± 10%	Explore
brain	3 studies	35% ± 21%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	5594.33	966 / 966	98%	28.32	516 / 527
lung	100%	10407.98	578 / 578	97%	33.50	1126 / 1155
thymus	98%	3936.30	637 / 653	100%	37.96	604 / 605
uterus	100%	6915.03	170 / 170	96%	34.17	439 / 459
esophagus	100%	5510.35	1442 / 1445	96%	33.42	175 / 183
bladder	100%	5396.33	21 / 21	94%	31.54	475 / 504
ovary	100%	4942.09	180 / 180	94%	29.58	404 / 430
breast	100%	8529.25	459 / 459	90%	20.49	1010 / 1118
stomach	92%	3297.13	330 / 359	98%	30.41	280 / 286
prostate	99%	4747.88	242 / 245	91%	19.29	456 / 502
brain	83%	3118.42	2191 / 2642	100%	66.18	703 / 705
skin	97%	4273.94	1758 / 1809	82%	23.34	388 / 472
kidney	76%	1943.18	68 / 89	93%	42.18	840 / 901
adrenal gland	83%	2046.40	214 / 258	82%	17.21	189 / 230
pancreas	24%	475.15	78 / 328	98%	49.70	175 / 178
adipose	100%	11055.29	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	51.99	29 / 29
spleen	100%	24739.15	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	39.08	1 / 1
blood vessel	100%	6263.06	1329 / 1335	0%	0	0 / 0
heart	98%	3869.10	842 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	53.70	44 / 45
peripheral blood	96%	93841.13	891 / 929	0%	0	0 / 0
liver	12%	269.50	28 / 226	72%	14.58	293 / 406
muscle	38%	725.92	305 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	30%	4.19	24 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0120158	Biological process	positive regulation of collagen catabolic process
GO_0010628	Biological process	positive regulation of gene expression
GO_0050776	Biological process	regulation of immune response
GO_0032693	Biological process	negative regulation of interleukin-10 production
GO_0031638	Biological process	zymogen activation
GO_0030335	Biological process	positive regulation of cell migration
GO_0032689	Biological process	negative regulation of type II interferon production
GO_2000565	Biological process	negative regulation of CD8-positive, alpha-beta T cell proliferation
GO_0032700	Biological process	negative regulation of interleukin-17 production
GO_0032720	Biological process	negative regulation of tumor necrosis factor production
GO_0010950	Biological process	positive regulation of endopeptidase activity
GO_0045591	Biological process	positive regulation of regulatory T cell differentiation
GO_0046636	Biological process	negative regulation of alpha-beta T cell activation
GO_2000562	Biological process	negative regulation of CD4-positive, alpha-beta T cell proliferation
GO_0005886	Cellular component	plasma membrane
GO_0019899	Molecular function	enzyme binding
GO_0061133	Molecular function	endopeptidase activator activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	VSIR
Protein name	C10orf54 protein V-type immunoglobulin domain-containing suppressor of T-cell activation (Platelet receptor Gi24) (Stress-induced secreted protein-1) (Sisp-1) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor)
Synonyms	UNQ730/PRO1412 VISTA SISP1 C10orf54 PP2135
Description	FUNCTION: Immunoregulatory receptor which inhibits the T-cell response . May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation . .
Accessions	Q2TA85 ENST00000394957.8 Q9H7M9

VSIR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review