VPS51 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007041Biological processlysosomal transport
GO_0032456Biological processendocytic recycling
GO_0006605Biological processprotein targeting
GO_0048193Biological processGolgi vesicle transport
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0007030Biological processGolgi organization
GO_0048854Biological processbrain morphogenesis
GO_0015031Biological processprotein transport
GO_0090119Biological processvesicle-mediated cholesterol transport
GO_0006914Biological processautophagy
GO_0005730Cellular componentnucleolus
GO_0016020Cellular componentmembrane
GO_0055037Cellular componentrecycling endosome
GO_1990745Cellular componentEARP complex
GO_0005794Cellular componentGolgi apparatus
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000938Cellular componentGARP complex
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameVPS51
Protein nameVacuolar protein sorting-associated protein 51 homolog
Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog)
VPS51 subunit of GARP complex
SynonymsANG2
FFR
PP5382
C11orf3
C11orf2
DescriptionFUNCTION: Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN . Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane . .

FUNCTION: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling. .

FUNCTION: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling. .

FUNCTION: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling. .

FUNCTION: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling. .

FUNCTION: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling. .

FUNCTION: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling. .

FUNCTION: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling. .

FUNCTION: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling. .

AccessionsENST00000526578.5
E9PQD5
ENST00000528588.5
ENST00000533487.1
ENST00000534557.1
ENST00000279281.8 [Q9UID3-1]
H0YEE1
E9PMB6
Q9UID3
E9PRV0
E9PKX7
H0YCB7
ENST00000530673.1
E9PJ36
ENST00000533827.5
ENST00000534124.5
E9PKE5
ENST00000530773.5
ENST00000529180.1
E9PQN6
H0YDX9
ENST00000526856.5