USP22 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	22 studies	23% ± 7%	Explore
endothelial cell	21 studies	30% ± 13%	Explore
pericyte	14 studies	22% ± 6%	Explore
ciliated cell	12 studies	28% ± 11%	Explore
glutamatergic neuron	11 studies	42% ± 20%	Explore
astrocyte	11 studies	24% ± 10%	Explore
oligodendrocyte precursor cell	11 studies	29% ± 12%	Explore
neuron	10 studies	42% ± 15%	Explore
oligodendrocyte	10 studies	25% ± 9%	Explore
B cell	9 studies	22% ± 4%	Explore
basal cell	9 studies	29% ± 11%	Explore
smooth muscle cell	9 studies	20% ± 4%	Explore
GABAergic neuron	9 studies	40% ± 19%	Explore
endothelial cell of lymphatic vessel	8 studies	21% ± 5%	Explore
epithelial cell	8 studies	39% ± 19%	Explore
microglial cell	8 studies	25% ± 8%	Explore
myofibroblast cell	8 studies	23% ± 6%	Explore
type I pneumocyte	7 studies	23% ± 5%	Explore
interneuron	6 studies	40% ± 20%	Explore
macrophage	6 studies	28% ± 6%	Explore
naive B cell	6 studies	18% ± 2%	Explore
myeloid cell	6 studies	20% ± 4%	Explore
adipocyte	6 studies	23% ± 7%	Explore
hematopoietic precursor cell	5 studies	30% ± 16%	Explore
club cell	5 studies	26% ± 9%	Explore
respiratory goblet cell	5 studies	25% ± 13%	Explore
classical monocyte	5 studies	24% ± 8%	Explore
abnormal cell	5 studies	30% ± 11%	Explore
endothelial cell of artery	5 studies	17% ± 4%	Explore
vein endothelial cell	5 studies	25% ± 10%	Explore
amacrine cell	5 studies	34% ± 10%	Explore
hematopoietic stem cell	5 studies	21% ± 6%	Explore
retina horizontal cell	5 studies	29% ± 10%	Explore
connective tissue cell	5 studies	24% ± 8%	Explore
goblet cell	5 studies	32% ± 18%	Explore
natural killer cell	4 studies	17% ± 2%	Explore
secretory cell	4 studies	26% ± 3%	Explore
squamous epithelial cell	4 studies	30% ± 23%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	16% ± 1%	Explore
mesothelial cell	4 studies	16% ± 1%	Explore
granule cell	4 studies	26% ± 9%	Explore
progenitor cell	4 studies	21% ± 5%	Explore
retinal ganglion cell	4 studies	44% ± 21%	Explore
precursor B cell	4 studies	25% ± 1%	Explore
pro-B cell	4 studies	31% ± 7%	Explore
brush cell	4 studies	33% ± 9%	Explore
capillary endothelial cell	4 studies	22% ± 6%	Explore
Mueller cell	4 studies	18% ± 2%	Explore
enteroendocrine cell	4 studies	29% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	17% ± 1%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	16% ± 0%	Explore
CD4-positive, alpha-beta T cell	3 studies	23% ± 3%	Explore
neural crest cell	3 studies	22% ± 1%	Explore
retinal bipolar neuron	3 studies	24% ± 3%	Explore
GABAergic interneuron	3 studies	30% ± 4%	Explore
glial cell	3 studies	31% ± 16%	Explore
type II pneumocyte	3 studies	23% ± 4%	Explore
lymphocyte	3 studies	23% ± 6%	Explore
rod bipolar cell	3 studies	20% ± 4%	Explore
endothelial cell of vascular tree	3 studies	24% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	22% ± 3%	Explore
ependymal cell	3 studies	31% ± 13%	Explore
mast cell	3 studies	26% ± 7%	Explore
intestinal crypt stem cell	3 studies	18% ± 3%	Explore
transit amplifying cell	3 studies	33% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	34% ± 14%	Explore
lung	8 studies	23% ± 4%	Explore
eye	5 studies	24% ± 10%	Explore
intestine	4 studies	24% ± 10%	Explore
peripheral blood	3 studies	30% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	11564.61	2638 / 2642	100%	121.90	702 / 705
esophagus	100%	6967.35	1445 / 1445	98%	69.51	180 / 183
stomach	100%	6821.58	359 / 359	98%	65.38	281 / 286
prostate	100%	8561.73	245 / 245	98%	95.58	493 / 502
skin	100%	8442.82	1809 / 1809	98%	115.06	463 / 472
intestine	100%	7714.28	966 / 966	98%	61.39	516 / 527
lung	100%	7937.93	578 / 578	98%	67.91	1130 / 1155
breast	100%	7833.93	459 / 459	97%	98.46	1090 / 1118
thymus	100%	8467.21	653 / 653	97%	79.57	588 / 605
kidney	100%	7201.71	89 / 89	96%	74.41	864 / 901
ovary	100%	10929.38	180 / 180	95%	58.58	408 / 430
pancreas	98%	4775.31	321 / 328	96%	48.92	171 / 178
uterus	100%	11340.44	170 / 170	93%	64.59	425 / 459
bladder	100%	7382.14	21 / 21	92%	55.84	465 / 504
adrenal gland	100%	11084.01	258 / 258	90%	67.18	207 / 230
liver	99%	3726.96	223 / 226	72%	28.72	293 / 406
adipose	100%	6976.97	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7504.26	1335 / 1335	0%	0	0 / 0
muscle	100%	11185.89	803 / 803	0%	0	0 / 0
spleen	100%	7156.66	241 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	99%	89.71	79 / 80
heart	99%	7296.10	849 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	69.73	43 / 45
lymph node	0%	0	0 / 0	93%	59.21	27 / 29
peripheral blood	81%	3932.13	750 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0006282	Biological process	regulation of DNA repair
GO_0009792	Biological process	embryo development ending in birth or egg hatching
GO_0032481	Biological process	positive regulation of type I interferon production
GO_0006338	Biological process	chromatin remodeling
GO_0045931	Biological process	positive regulation of mitotic cell cycle
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0006508	Biological process	proteolysis
GO_0016579	Biological process	protein deubiquitination
GO_0043484	Biological process	regulation of RNA splicing
GO_0000086	Biological process	G2/M transition of mitotic cell cycle
GO_0005654	Cellular component	nucleoplasm
GO_0033276	Cellular component	transcription factor TFTC complex
GO_0005737	Cellular component	cytoplasm
GO_0000124	Cellular component	SAGA complex
GO_0005634	Cellular component	nucleus
GO_0019899	Molecular function	enzyme binding
GO_0140950	Molecular function	histone H2A deubiquitinase activity
GO_0004843	Molecular function	cysteine-type deubiquitinase activity
GO_0010485	Molecular function	histone H4 acetyltransferase activity
GO_0008270	Molecular function	zinc ion binding
GO_0140936	Molecular function	histone H2B deubiquitinase activity
GO_0003713	Molecular function	transcription coactivator activity
GO_0030374	Molecular function	nuclear receptor coactivator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	USP22
Protein name	Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22) Ubiquitin specific peptidase 22 ubiquitinyl hydrolase 1 (EC 3.4.19.12)
Synonyms	USP3L KIAA1063
Description	FUNCTION: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression. .
Accessions	ENST00000584538.1 K7ERX6 J3QRV6 ENST00000579645.5 ENST00000476111.5 ENST00000261497.9 [Q9UPT9-1] Q9UPT9 J3QS30 ENST00000537526.6 [Q9UPT9-2] ENST00000582335.1 K7ESK0

USP22 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review