TMPO | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	25 studies	24% ± 8%	Explore
non-classical monocyte	19 studies	33% ± 14%	Explore
regulatory T cell	17 studies	24% ± 9%	Explore
T cell	16 studies	27% ± 11%	Explore
CD8-positive, alpha-beta T cell	16 studies	29% ± 13%	Explore
natural killer cell	15 studies	29% ± 14%	Explore
endothelial cell	15 studies	23% ± 9%	Explore
CD4-positive, alpha-beta T cell	14 studies	30% ± 15%	Explore
classical monocyte	14 studies	25% ± 11%	Explore
monocyte	12 studies	24% ± 9%	Explore
naive B cell	12 studies	24% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	21% ± 3%	Explore
memory B cell	10 studies	20% ± 4%	Explore
gamma-delta T cell	10 studies	25% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	20% ± 4%	Explore
plasmablast	7 studies	44% ± 20%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	29% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	21% ± 4%	Explore
epithelial cell	7 studies	37% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	22% ± 3%	Explore
hematopoietic precursor cell	6 studies	28% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	22% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	18% ± 2%	Explore
conventional dendritic cell	6 studies	25% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	20% ± 4%	Explore
macrophage	6 studies	23% ± 5%	Explore
mucosal invariant T cell	6 studies	19% ± 5%	Explore
precursor B cell	6 studies	36% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	20% ± 4%	Explore
leukocyte	5 studies	25% ± 13%	Explore
progenitor cell	5 studies	20% ± 6%	Explore
connective tissue cell	5 studies	26% ± 6%	Explore
pro-B cell	5 studies	36% ± 5%	Explore
dendritic cell	5 studies	27% ± 13%	Explore
erythrocyte	5 studies	32% ± 18%	Explore
neuron	5 studies	24% ± 5%	Explore
T follicular helper cell	5 studies	20% ± 4%	Explore
mature NK T cell	5 studies	18% ± 1%	Explore
GABAergic neuron	5 studies	24% ± 4%	Explore
plasmacytoid dendritic cell	4 studies	20% ± 5%	Explore
exhausted T cell	4 studies	24% ± 6%	Explore
abnormal cell	4 studies	35% ± 6%	Explore
transit amplifying cell	4 studies	39% ± 16%	Explore
erythroblast	4 studies	47% ± 22%	Explore
lymphocyte	4 studies	30% ± 10%	Explore
plasma cell	4 studies	30% ± 12%	Explore
basal cell	4 studies	25% ± 8%	Explore
fibroblast	4 studies	21% ± 3%	Explore
glutamatergic neuron	4 studies	30% ± 7%	Explore
interneuron	4 studies	25% ± 10%	Explore
myofibroblast cell	3 studies	19% ± 1%	Explore
neural crest cell	3 studies	35% ± 9%	Explore
pericyte	3 studies	19% ± 2%	Explore
myeloid cell	3 studies	26% ± 3%	Explore
ciliated cell	3 studies	28% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	20% ± 2%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	39% ± 6%	Explore
goblet cell	3 studies	25% ± 8%	Explore
intestinal crypt stem cell	3 studies	23% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 14%	Explore
oligodendrocyte	3 studies	17% ± 1%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	26% ± 6%	Explore
microglial cell	3 studies	24% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	24% ± 7%	Explore
liver	6 studies	30% ± 21%	Explore
brain	5 studies	23% ± 4%	Explore
lung	4 studies	21% ± 3%	Explore
intestine	4 studies	21% ± 6%	Explore
kidney	3 studies	20% ± 1%	Explore
bone marrow	3 studies	20% ± 3%	Explore
lymph node	3 studies	25% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2913.12	1445 / 1445	100%	50.87	183 / 183
lung	100%	3042.03	577 / 578	100%	48.82	1154 / 1155
stomach	100%	2901.90	359 / 359	100%	52.41	285 / 286
uterus	100%	4242.14	170 / 170	100%	73.60	457 / 459
breast	100%	2881.40	459 / 459	99%	48.03	1111 / 1118
ovary	100%	6544.51	180 / 180	99%	39.13	427 / 430
bladder	100%	2563.19	21 / 21	99%	53.50	500 / 504
intestine	100%	3380.94	966 / 966	99%	56.36	522 / 527
pancreas	99%	2590.97	326 / 328	97%	30.44	173 / 178
brain	98%	1517.89	2588 / 2642	99%	30.98	695 / 705
prostate	100%	2493.68	245 / 245	95%	20.09	476 / 502
thymus	100%	2311.62	652 / 653	94%	32.58	570 / 605
skin	100%	3930.43	1806 / 1809	92%	34.68	433 / 472
liver	100%	2214.77	225 / 226	92%	27.22	373 / 406
kidney	100%	2079.43	89 / 89	91%	23.32	816 / 901
adrenal gland	100%	1771.10	258 / 258	78%	21.36	179 / 230
lymph node	0%	0	0 / 0	100%	78.14	29 / 29
spleen	100%	5054.36	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	89.62	45 / 45
ureter	0%	0	0 / 0	100%	25.03	1 / 1
blood vessel	100%	2201.21	1334 / 1335	0%	0	0 / 0
adipose	100%	2436.55	1203 / 1204	0%	0	0 / 0
heart	98%	1230.41	843 / 861	0%	0	0 / 0
peripheral blood	96%	5584.79	891 / 929	0%	0	0 / 0
muscle	92%	850.83	738 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	44%	6.10	35 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000785	Cellular component	chromatin
GO_0031965	Cellular component	nuclear membrane
GO_0005637	Cellular component	nuclear inner membrane
GO_0005635	Cellular component	nuclear envelope
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0045296	Molecular function	cadherin binding
GO_0003677	Molecular function	DNA binding
GO_0005521	Molecular function	lamin binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TMPO
Protein name	Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] Thymopoietin Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]
Synonyms	hCG_2015322 LAP2
Description	FUNCTION: May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. FUNCTION: May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.; FUNCTION: Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
Accessions	H0YJH7 P42167 ENST00000261210.9 [P42167-3] ENST00000393053.6 [P42167-2] G5E972 ENST00000556029.6 [P42167-1] ENST00000343315.9 ENST00000266732.8 [P42166-1] P42166 ENST00000556678.1

TMPO report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review