Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 8 studies | 22% ± 5% | |
lung | 6 studies | 28% ± 7% | |
pancreas | 4 studies | 55% ± 21% | |
placenta | 4 studies | 28% ± 5% | |
intestine | 4 studies | 24% ± 10% | |
liver | 4 studies | 26% ± 10% | |
bone marrow | 3 studies | 17% ± 1% | |
brain | 3 studies | 22% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 11191.27 | 459 / 459 | 100% | 296.57 | 1118 / 1118 |
esophagus | 100% | 8595.15 | 1445 / 1445 | 100% | 274.72 | 183 / 183 |
liver | 100% | 16758.04 | 226 / 226 | 100% | 274.41 | 406 / 406 |
lung | 100% | 12444.91 | 578 / 578 | 100% | 313.94 | 1155 / 1155 |
ovary | 100% | 8327.11 | 180 / 180 | 100% | 218.29 | 430 / 430 |
pancreas | 100% | 11661.20 | 328 / 328 | 100% | 286.55 | 178 / 178 |
prostate | 100% | 10333.62 | 245 / 245 | 100% | 369.90 | 502 / 502 |
stomach | 100% | 9529.79 | 359 / 359 | 100% | 302.53 | 286 / 286 |
intestine | 100% | 9714.11 | 966 / 966 | 100% | 325.42 | 526 / 527 |
skin | 100% | 15101.26 | 1809 / 1809 | 100% | 307.22 | 470 / 472 |
bladder | 100% | 9029.95 | 21 / 21 | 99% | 264.67 | 501 / 504 |
uterus | 100% | 10513.06 | 170 / 170 | 99% | 241.03 | 456 / 459 |
thymus | 100% | 10601.01 | 653 / 653 | 99% | 238.13 | 600 / 605 |
adrenal gland | 100% | 14239.64 | 258 / 258 | 99% | 259.75 | 227 / 230 |
kidney | 100% | 8556.36 | 89 / 89 | 99% | 186.09 | 889 / 901 |
brain | 97% | 4032.93 | 2568 / 2642 | 100% | 187.85 | 704 / 705 |
adipose | 100% | 12411.60 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 191.56 | 29 / 29 |
spleen | 100% | 8433.17 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 217.64 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 166.57 | 1 / 1 |
blood vessel | 100% | 9044.26 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 4904.83 | 797 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 6646.79 | 848 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 157.12 | 78 / 80 |
peripheral blood | 96% | 6472.14 | 893 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0032527 | Biological process | protein exit from endoplasmic reticulum |
GO_0034498 | Biological process | early endosome to Golgi transport |
GO_0007030 | Biological process | Golgi organization |
GO_0010638 | Biological process | positive regulation of organelle organization |
GO_0032368 | Biological process | regulation of lipid transport |
GO_0042953 | Biological process | lipoprotein transport |
GO_0055088 | Biological process | lipid homeostasis |
GO_0006888 | Biological process | endoplasmic reticulum to Golgi vesicle-mediated transport |
GO_0140353 | Biological process | lipid export from cell |
GO_0090110 | Biological process | COPII-coated vesicle cargo loading |
GO_0005886 | Cellular component | plasma membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0035577 | Cellular component | azurophil granule membrane |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0070971 | Cellular component | endoplasmic reticulum exit site |
GO_0033116 | Cellular component | endoplasmic reticulum-Golgi intermediate compartment membrane |
GO_0000139 | Cellular component | Golgi membrane |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005829 | Cellular component | cytosol |
GO_0005793 | Cellular component | endoplasmic reticulum-Golgi intermediate compartment |
GO_0030134 | Cellular component | COPII-coated ER to Golgi transport vesicle |
GO_0030133 | Cellular component | transport vesicle |
GO_0031965 | Cellular component | nuclear membrane |
GO_0097020 | Molecular function | COPII receptor activity |
GO_0038024 | Molecular function | cargo receptor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | SURF4 |
Protein name | Surfeit locus protein 4 |
Synonyms | SURF-4 RP11-244N20.4-002 RP11-244N20.4-004 hCG_28148 |
Description | FUNCTION: Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion . Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis . Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins . Promotes the secretion of PCSK9 . Also mediates the efficient secretion of erythropoietin (EPO) . May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi . . |
Accessions | ENST00000545297.5 [O15260-3] Q5T8U5 ENST00000618229.4 B7Z1G8 ENST00000371989.8 [O15260-1] ENST00000626303.2 [O15260-2] ENST00000629119.2 [O15260-3] ENST00000629578.3 [O15260-1] ENST00000371991.3 Q5T8U7 ENST00000485435.6 [O15260-2] ENST00000613129.4 O15260 |