SURF4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032527Biological processprotein exit from endoplasmic reticulum
GO_0034498Biological processearly endosome to Golgi transport
GO_0007030Biological processGolgi organization
GO_0010638Biological processpositive regulation of organelle organization
GO_0032368Biological processregulation of lipid transport
GO_0042953Biological processlipoprotein transport
GO_0055088Biological processlipid homeostasis
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0140353Biological processlipid export from cell
GO_0090110Biological processCOPII-coated vesicle cargo loading
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0035577Cellular componentazurophil granule membrane
GO_0005794Cellular componentGolgi apparatus
GO_0070971Cellular componentendoplasmic reticulum exit site
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005793Cellular componentendoplasmic reticulum-Golgi intermediate compartment
GO_0030134Cellular componentCOPII-coated ER to Golgi transport vesicle
GO_0030133Cellular componenttransport vesicle
GO_0031965Cellular componentnuclear membrane
GO_0097020Molecular functionCOPII receptor activity
GO_0038024Molecular functioncargo receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSURF4
Protein nameSurfeit locus protein 4
SynonymsSURF-4
RP11-244N20.4-002
RP11-244N20.4-004
hCG_28148
DescriptionFUNCTION: Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion . Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis . Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins . Promotes the secretion of PCSK9 . Also mediates the efficient secretion of erythropoietin (EPO) . May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi . .

AccessionsENST00000545297.5 [O15260-3]
Q5T8U5
ENST00000618229.4
B7Z1G8
ENST00000371989.8 [O15260-1]
ENST00000626303.2 [O15260-2]
ENST00000629119.2 [O15260-3]
ENST00000629578.3 [O15260-1]
ENST00000371991.3
Q5T8U7
ENST00000485435.6 [O15260-2]
ENST00000613129.4
O15260