STIM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032237Biological processactivation of store-operated calcium channel activity
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0070588Biological processcalcium ion transmembrane transport
GO_0002115Biological processstore-operated calcium entry
GO_0051928Biological processpositive regulation of calcium ion transport
GO_0005783Cellular componentendoplasmic reticulum
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005246Molecular functioncalcium channel regulator activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0015279Molecular functionstore-operated calcium channel activity

IV. Literature review

[source]
Gene nameSTIM2
Protein nameSTIM2 protein
Stromal interaction molecule 2
SynonymsKIAA1482
DescriptionFUNCTION: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. .

AccessionsH7C5C6
H0Y860
ENST00000477474.3
A0A1X7SBY3
ENST00000698882.1
ENST00000467087.7 [Q9P246-1]
ENST00000463501.5
ENST00000494628.6
ENST00000467087
ENST00000467011
H7C5A5
ENST00000467011.6 [Q9P246-3]
H7C5K2
ENST00000478049.1
R4GN82
A0A8V8TMC8
ENST00000473519.5
Q05BJ5
R4GMP0
R4GNC5
ENST00000465503.6
Q9P246