ST3GAL1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	23 studies	28% ± 16%	Explore
natural killer cell	22 studies	22% ± 5%	Explore
endothelial cell	21 studies	24% ± 9%	Explore
CD4-positive, alpha-beta T cell	19 studies	23% ± 4%	Explore
CD8-positive, alpha-beta T cell	18 studies	21% ± 3%	Explore
T cell	16 studies	23% ± 6%	Explore
fibroblast	15 studies	24% ± 6%	Explore
gamma-delta T cell	13 studies	24% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	23% ± 4%	Explore
non-classical monocyte	11 studies	21% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	26% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	23% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	25% ± 7%	Explore
mucosal invariant T cell	11 studies	22% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	21% ± 5%	Explore
mature NK T cell	10 studies	20% ± 6%	Explore
naive B cell	10 studies	19% ± 3%	Explore
myeloid cell	10 studies	32% ± 10%	Explore
adipocyte	10 studies	40% ± 17%	Explore
microglial cell	9 studies	31% ± 8%	Explore
monocyte	8 studies	30% ± 10%	Explore
classical monocyte	8 studies	20% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	26% ± 4%	Explore
B cell	8 studies	18% ± 2%	Explore
endothelial cell of lymphatic vessel	7 studies	29% ± 10%	Explore
dendritic cell	7 studies	25% ± 5%	Explore
mast cell	7 studies	21% ± 7%	Explore
innate lymphoid cell	7 studies	26% ± 6%	Explore
astrocyte	7 studies	27% ± 12%	Explore
type II pneumocyte	6 studies	22% ± 4%	Explore
regulatory T cell	5 studies	16% ± 0%	Explore
epithelial cell	5 studies	25% ± 6%	Explore
cardiac muscle cell	5 studies	54% ± 16%	Explore
hepatocyte	5 studies	47% ± 26%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	23% ± 4%	Explore
conventional dendritic cell	4 studies	20% ± 4%	Explore
retina horizontal cell	4 studies	21% ± 2%	Explore
mesothelial cell	4 studies	25% ± 5%	Explore
lymphocyte	4 studies	40% ± 14%	Explore
endothelial cell of vascular tree	4 studies	23% ± 10%	Explore
hematopoietic stem cell	3 studies	17% ± 2%	Explore
memory B cell	3 studies	20% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	20% ± 3%	Explore
intermediate monocyte	3 studies	27% ± 11%	Explore
GABAergic neuron	3 studies	32% ± 6%	Explore
glutamatergic neuron	3 studies	36% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	24% ± 4%	Explore
connective tissue cell	3 studies	21% ± 2%	Explore
adventitial cell	3 studies	23% ± 3%	Explore
club cell	3 studies	21% ± 3%	Explore
alveolar macrophage	3 studies	48% ± 13%	Explore
capillary endothelial cell	3 studies	19% ± 2%	Explore
T follicular helper cell	3 studies	26% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 12%	Explore
muscle cell	3 studies	25% ± 7%	Explore
leukocyte	3 studies	38% ± 11%	Explore
smooth muscle cell	3 studies	19% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	25% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	20% ± 3%	Explore
lung	6 studies	22% ± 7%	Explore
brain	5 studies	25% ± 10%	Explore
heart	4 studies	33% ± 8%	Explore
liver	4 studies	24% ± 8%	Explore
adipose	4 studies	28% ± 12%	Explore
bone marrow	3 studies	18% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	4214.16	458 / 459	97%	55.96	1086 / 1118
thymus	100%	17453.33	653 / 653	95%	111.34	576 / 605
kidney	100%	5924.03	89 / 89	94%	32.45	845 / 901
liver	100%	8879.12	226 / 226	90%	43.64	365 / 406
ovary	99%	3713.93	179 / 180	90%	37.42	385 / 430
lung	100%	6565.03	578 / 578	89%	35.16	1027 / 1155
esophagus	99%	3236.87	1432 / 1445	89%	30.17	163 / 183
pancreas	94%	2204.86	307 / 328	92%	44.69	164 / 178
uterus	100%	3657.34	170 / 170	81%	23.64	370 / 459
bladder	100%	5478.67	21 / 21	77%	29.02	387 / 504
skin	79%	2184.57	1423 / 1809	94%	42.95	446 / 472
stomach	99%	4037.54	357 / 359	66%	15.02	190 / 286
adrenal gland	100%	7186.42	258 / 258	54%	19.42	125 / 230
intestine	87%	2142.91	838 / 966	53%	13.59	278 / 527
prostate	96%	2869.17	236 / 245	37%	5.81	186 / 502
brain	67%	1156.44	1771 / 2642	40%	5.53	283 / 705
adipose	100%	5970.95	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	95.62	80 / 80
muscle	100%	8352.37	803 / 803	0%	0	0 / 0
spleen	100%	6408.14	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	12.35	1 / 1
heart	99%	10099.41	849 / 861	0%	0	0 / 0
blood vessel	97%	4381.86	1300 / 1335	0%	0	0 / 0
peripheral blood	96%	4683.29	895 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	86%	25.88	25 / 29
tonsil	0%	0	0 / 0	84%	21.02	38 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010706	Biological process	ganglioside biosynthetic process via lactosylceramide
GO_0016266	Biological process	O-glycan processing
GO_0002319	Biological process	memory B cell differentiation
GO_0018146	Biological process	keratan sulfate biosynthetic process
GO_0097503	Biological process	sialylation
GO_1990743	Biological process	protein sialylation
GO_0036211	Biological process	protein modification process
GO_0019082	Biological process	viral protein processing
GO_0006054	Biological process	N-acetylneuraminate metabolic process
GO_1905403	Biological process	negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
GO_0006487	Biological process	protein N-linked glycosylation
GO_0006486	Biological process	protein glycosylation
GO_1990675	Cellular component	Golgi medial cisterna membrane
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0032588	Cellular component	trans-Golgi network membrane
GO_0000139	Cellular component	Golgi membrane
GO_1990676	Cellular component	Golgi trans cisterna membrane
GO_0008373	Molecular function	sialyltransferase activity
GO_0047288	Molecular function	beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase
GO_0003836	Molecular function	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity

IV. Literature review

[source]

Gene name	ST3GAL1
Protein name	ST3 beta-galactoside alpha-2,3-sialyltransferase 1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1) (Beta-galactoside alpha-2,3-sialyltransferase 1) (EC 2.4.3.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Monosialoganglioside sialyltransferase) (EC 2.4.3.2) (SIATFL) (ST3Gal I) (ST3GalI) (ST3GalA.1) (ST3O) (Sialyltransferase 4A) (SIAT4-A) beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase (EC 2.4.3.2) (Monosialoganglioside sialyltransferase)
Synonyms	SIAT4 SIAT4A
Description	FUNCTION: A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids . Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage . Adds sialic acid to the core 1 O-glycan, Galbeta-(1->3)-GalNAc-O-Ser/Thr, which is a major structure of mucin-type O-glycans. As part of a homeostatic mechanism that regulates CD8-positive T cell numbers, sialylates core 1 O-glycans of T cell glycoproteins, SPN/CD43 and PTPRC/CD45. Prevents premature apoptosis of thymic CD8-positive T cells prior to peripheral emigration, whereas in the secondary lymphoid organs controls the survival of CD8-positive memory T cells generated following a successful immune response (By similarity). Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser (By similarity). Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (By similarity). .
Accessions	ENST00000648219.1 ENST00000523855.1 E5RH34 Q11201 ENST00000519924.5 E5RGI3 E5RG72 ENST00000522652.6 ENST00000523854.5 ENST00000523634.1 ENST00000521180.5 E5RHV6 ENST00000517668.5 E5RGL4

ST3GAL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review