SSRP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0006337Biological processnucleosome disassembly
GO_1902275Biological processregulation of chromatin organization
GO_0006260Biological processDNA replication
GO_0006334Biological processnucleosome assembly
GO_0005730Cellular componentnucleolus
GO_0035101Cellular componentFACT complex
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0031491Molecular functionnucleosome binding
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0042393Molecular functionhistone binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameSSRP1
Protein nameAlternative protein SSRP1
FACT complex subunit SSRP1
Structure specific recognition protein 1
FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160)
SynonymsFACT80
DescriptionFUNCTION: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. .

FUNCTION: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. .

AccessionsQ08945
ENST00000529002.2
A0A0U1RRK2
L8EA29
ENST00000635721.1
ENST00000526696.6
E9PMD4
E9PPZ7
ENST00000278412.7