SIK3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	23 studies	51% ± 20%	Explore
astrocyte	19 studies	64% ± 18%	Explore
oligodendrocyte	16 studies	82% ± 19%	Explore
oligodendrocyte precursor cell	15 studies	65% ± 18%	Explore
microglial cell	14 studies	49% ± 14%	Explore
fibroblast	14 studies	45% ± 16%	Explore
smooth muscle cell	13 studies	43% ± 16%	Explore
glutamatergic neuron	12 studies	64% ± 23%	Explore
macrophage	12 studies	46% ± 19%	Explore
GABAergic neuron	11 studies	63% ± 22%	Explore
pericyte	11 studies	43% ± 15%	Explore
B cell	10 studies	43% ± 17%	Explore
myeloid cell	9 studies	34% ± 14%	Explore
adipocyte	9 studies	52% ± 12%	Explore
mast cell	8 studies	34% ± 14%	Explore
mesothelial cell	8 studies	44% ± 13%	Explore
ciliated cell	8 studies	42% ± 21%	Explore
T cell	8 studies	46% ± 24%	Explore
endothelial cell of lymphatic vessel	8 studies	44% ± 22%	Explore
epithelial cell	7 studies	43% ± 19%	Explore
CD8-positive, alpha-beta T cell	6 studies	34% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	33% ± 13%	Explore
neuron	6 studies	58% ± 19%	Explore
interneuron	6 studies	63% ± 22%	Explore
dendritic cell	6 studies	47% ± 10%	Explore
basal cell	6 studies	40% ± 16%	Explore
natural killer cell	6 studies	39% ± 14%	Explore
CD4-positive, alpha-beta T cell	5 studies	39% ± 14%	Explore
leukocyte	5 studies	54% ± 18%	Explore
cardiac muscle cell	5 studies	60% ± 15%	Explore
monocyte	5 studies	69% ± 9%	Explore
club cell	5 studies	43% ± 13%	Explore
type I pneumocyte	5 studies	53% ± 15%	Explore
type II pneumocyte	5 studies	58% ± 17%	Explore
hepatocyte	4 studies	66% ± 26%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	39% ± 15%	Explore
classical monocyte	4 studies	25% ± 6%	Explore
granule cell	4 studies	59% ± 21%	Explore
plasma cell	4 studies	44% ± 13%	Explore
vein endothelial cell	4 studies	38% ± 19%	Explore
lymphocyte	4 studies	53% ± 17%	Explore
Mueller cell	4 studies	80% ± 10%	Explore
amacrine cell	4 studies	51% ± 19%	Explore
retina horizontal cell	4 studies	54% ± 13%	Explore
retinal cone cell	4 studies	84% ± 13%	Explore
retinal ganglion cell	4 studies	58% ± 20%	Explore
retinal rod cell	4 studies	69% ± 11%	Explore
gamma-delta T cell	4 studies	21% ± 6%	Explore
regulatory T cell	4 studies	31% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	25% ± 11%	Explore
non-classical monocyte	3 studies	33% ± 7%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	74% ± 8%	Explore
GABAergic interneuron	3 studies	65% ± 7%	Explore
glial cell	3 studies	53% ± 12%	Explore
mucosal invariant T cell	3 studies	40% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	34% ± 13%	Explore
GABAergic amacrine cell	3 studies	50% ± 14%	Explore
OFF-bipolar cell	3 studies	38% ± 5%	Explore
ON-bipolar cell	3 studies	38% ± 9%	Explore
glycinergic amacrine cell	3 studies	53% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	24% ± 4%	Explore
naive B cell	3 studies	19% ± 1%	Explore
endothelial cell of vascular tree	3 studies	47% ± 15%	Explore
cholangiocyte	3 studies	60% ± 9%	Explore
mature NK T cell	3 studies	37% ± 25%	Explore
retinal pigment epithelial cell	3 studies	44% ± 31%	Explore
ependymal cell	3 studies	71% ± 5%	Explore
alveolar macrophage	3 studies	61% ± 9%	Explore
capillary endothelial cell	3 studies	34% ± 6%	Explore
myofibroblast cell	3 studies	49% ± 22%	Explore
respiratory goblet cell	3 studies	39% ± 18%	Explore
Schwann cell	3 studies	36% ± 12%	Explore
goblet cell	3 studies	42% ± 30%	Explore
mural cell	3 studies	51% ± 6%	Explore
mucus secreting cell	3 studies	33% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	66% ± 19%	Explore
lung	6 studies	42% ± 17%	Explore
eye	6 studies	53% ± 19%	Explore
heart	5 studies	42% ± 15%	Explore
liver	3 studies	49% ± 25%	Explore
peripheral blood	3 studies	22% ± 4%	Explore
adipose	3 studies	47% ± 15%	Explore
kidney	3 studies	53% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	7358.11	2642 / 2642	100%	36.70	705 / 705
esophagus	100%	4008.04	1445 / 1445	100%	16.89	183 / 183
thymus	100%	5412.74	653 / 653	100%	20.06	604 / 605
ovary	100%	4555.18	180 / 180	99%	15.71	427 / 430
stomach	100%	3425.12	359 / 359	99%	13.18	284 / 286
intestine	100%	4696.74	966 / 966	99%	10.66	523 / 527
prostate	100%	3673.13	245 / 245	99%	10.84	497 / 502
lung	100%	4250.18	577 / 578	99%	13.40	1143 / 1155
breast	100%	4341.17	459 / 459	99%	18.25	1103 / 1118
pancreas	100%	2191.36	327 / 328	99%	12.33	176 / 178
kidney	100%	3053.83	89 / 89	98%	12.34	886 / 901
uterus	100%	4888.86	170 / 170	98%	10.93	450 / 459
liver	100%	2667.62	226 / 226	98%	8.90	396 / 406
skin	100%	3307.25	1808 / 1809	97%	11.33	460 / 472
bladder	100%	3931.10	21 / 21	97%	9.27	490 / 504
adrenal gland	100%	2914.25	258 / 258	95%	12.55	218 / 230
adipose	100%	3455.68	1204 / 1204	0%	0	0 / 0
muscle	100%	3982.50	803 / 803	0%	0	0 / 0
spleen	100%	4122.56	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	4.10	1 / 1
blood vessel	100%	4388.23	1334 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	15.99	79 / 80
peripheral blood	99%	3419.85	917 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	9.43	44 / 45
lymph node	0%	0	0 / 0	97%	14.59	28 / 29
heart	95%	2794.48	819 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0035556	Biological process	intracellular signal transduction
GO_0006468	Biological process	protein phosphorylation
GO_1904263	Biological process	positive regulation of TORC1 signaling
GO_0000226	Biological process	microtubule cytoskeleton organization
GO_1904515	Biological process	positive regulation of TORC2 signaling
GO_0005737	Cellular component	cytoplasm
GO_0005524	Molecular function	ATP binding
GO_0050321	Molecular function	tau-protein kinase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0106310	Molecular function	protein serine kinase activity
GO_0005515	Molecular function	protein binding
GO_0000287	Molecular function	magnesium ion binding

IV. Literature review

[source]

Gene name	SIK3
Protein name	non-specific serine/threonine protein kinase (EC 2.7.11.1) SIK family kinase 3 Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK)
Synonyms	L19 KIAA0999 QSK
Description	FUNCTION: Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis . Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity). .
Accessions	ENST00000454905.5 Q9Y2K2 ENST00000445177.6 H0Y4E8 ENST00000446921.6 [Q9Y2K2-8] H7C038 H7C042 ENST00000413553.1 M5FMX3 ENST00000415541.5 H7C3X8 ENST00000375300.6 [Q9Y2K2-5]

SIK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review